Rabbit Anti-SENP1 Polyclonal Antibody – Cat# MBS1753025

Figure 1. Western blot analysis of SENP1 using anti-SENP1 antibody.

SENP1 Antibody – Rabbit Polyclonal

Name: SENP1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1753025
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753025

Description: Rabbit IgG polyclonal antibody for SENP1 detection. Tested with WB, FCM, Direct ELISA in Human.Background: Sentrin-specific protease 1 is a protein that in human is encoded by the SENP1 gene. This gene is mapped to 12q13.11. This gene encodes a… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SENP1, Polyclonal Antibody

Full Product Name

Anti-SENP1 Antibody

Product Gene Name

anti-SENP1 antibody

Product Synonym Names

Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SENP1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

612157

3D Structure

ModBase 3D Structure for Q9P0U3

Immunogen

E Coli-derived human SENP1 recombinant protein (Position: N19-P619).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-SENP1 antibody

Western Blot (WB), Flow Cytometry (FC/FACS), Direct ELISA (EIA)

Application Notes for anti-SENP1 antibody

WB: 0.25-0.5ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-SENP1 antibody

1. Veltman, I. M., Vreede, L. A., Cheng, J., Looijenga, L. H. J., Janssen, B., Schoenmakers, E. F. P. M., Yeh, E. T. H., Geurts van Kessel, A. Fusion of the SUMO/sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Hum. Molec. Genet. 14: 1955-1963, 2005.
2. Yamaguchi, T., Sharma, P., Athanasiou, M., Kumar, A., Yamada, S., Kuehn, M. R. Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Molec. Cell. Biol. 25: 5171-5182, 2005.
3. Yu, L., Ji, W., Zhang, H., Renda, M. J., He, Y., Lin, S., Cheng, E., Chen, H., Krause, D. S., Min, W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J. Exp. Med. 207: 1183-1195, 2010.

Other Notes

Small volumes of anti-SENP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SENP1 purchase

MBS1753025 is an antibody targeting SENP1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.

NCBI GI #

390131988

NCBI GeneID

29843

NCBI Accession #

NP_001254523.1

UniProt Primary Accession #

Q9P0U3

UniProt Related Accession #

Q9P0U3

GenBank Nucleotide #

NP_001254523.1

NCBI Official Full Name

sentrin-specific protease 1

NCBI Official Synonym Full Names

SUMO specific peptidase 1

NCBI Official Symbol

SENP1

NCBI Official Synonym Symbols

SuPr-2

UniProt Protein Name

Sentrin-specific protease 1

UniProt Synonym Protein Names

Sentrin/SUMO-specific protease SENP1

Protein Family

Sentrin-specific protease

UniProt Gene Name

SENP1

UniProt Entry Name

SENP1_HUMAN

NCBI Protein Information

sentrin-specific protease 1

NCBI Summary for SENP1

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UniProt Comments for SENP1

SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; cytoplasm; nucleus

Molecular Function: protein binding; endopeptidase activity; SUMO-specific protease activity

Biological Process: caspase activation; protein desumoylation; cellular protein metabolic process; protein sumoylation; positive regulation of transcription from RNA polymerase II promoter; proteolysis; post-translational protein modification; negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Research Articles on SENP1

1. Findings show that increased SUMOylation of CD45 via loss of SENP1 suppresses CD45-mediated dephosphorylation of STAT3, which promotes MDSC development and function, leading to tumorigenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SENP1 antibody

Reference Product	PubMed Publications
HDAC1 antibody	>1 publications with SENP1 and HDAC1

Pathways associated with anti-SENP1 antibody

Products by Pathway	Pathway Diagram
Regulation Of Androgen Receptor Activity Pathway antibodies	Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-SENP1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>5 publications with SENP1 and Cardiovascular Diseases
Anemia Antibodies	>2 publications with SENP1 and Anemia
Hypertension Antibodies	>2 publications with SENP1 and Hypertension
Hypertrophy Antibodies	>1 publications with SENP1 and Hypertrophy
Nervous System Diseases Antibodies	>1 publications with SENP1 and Nervous System Diseases
Weight Loss Antibodies	>1 publications with SENP1 and Weight Loss
Embryo Loss Antibodies	>1 publications with SENP1 and Embryo Loss
Necrosis Antibodies	>1 publications with SENP1 and Necrosis