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Rsk 2/MAPKAP Kinase 1b/RPS6KA3 (RPS6KA3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753027

Description: Rabbit IgG polyclonal antibody for Rsk 2/MAPKAP Kinase 1b/RPS6KA3 detection. Tested with WB, IHC-P, Direct ELISA in Human; Mouse; Rat.Background: Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in… More details

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Product Overview

Online Datasheet in PDF
Product Name
Rsk 2/MAPKAP Kinase 1b/RPS6KA3, Polyclonal Antibody
Full Product Name
Anti-Rsk 2/MAPKAP Kinase 1b/RPS6KA3 Antibody
Product Gene Name
anti-RPS6KA3 antibody
Product Synonym Names
Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; P90rsk3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2; RPS6KA3; ISPK1; MAPKAPK1B; RSK2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
300075
3D Structure
ModBase 3D Structure for P51812
Immunogen
E Coli-derived human Rsk 2/MAPKAP Kinase 1b/RPS6KA3 recombinant protein (Position: D393-K733).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-RPS6KA3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA)
Application Notes for anti-RPS6KA3 antibody
WB: 0.25-0.5ug/ml (Human, Mouse, Rat)
IHC-P (Embedded Section): 0.5-1ug/ml (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Western Blot (WB) of anti-RPS6KA3 antibody

Figure 1. Western blot analysis of RPS6KA3 using anti-RPS6KA3 antibody.
Rabbit Anti-RPS6KA3 Polyclonal Antibody – Cat# MBS1753027

Western Blot (WB) of anti-RPS6KA3 antibody

Rabbit Anti-RPS6KA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1753027

Product References and Citations for anti-RPS6KA3 antibody

1. Delaunoy, J.-P., Abidi, F., Zeniou, M., Jacquot, S., Merienne, K., Pannetier, S., Schmitt, M., Schwartz, C. E., Hanauer, A. Mutations in the X-linked RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome. Hum. Mutat. 17: 103-116, 2001.
2. Delaunoy, J. P., Dubos, A., Marques Pereira, P., Hanauer, A. Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome. Clin. Genet. 70: 161-166, 2006.
3. Field, M., Tarpey, P., Boyle, J., Edkins, S., Goodship, J., Luo, Y., Moon, J., Teague, J., Stratton, M. R., Futreal, P. A., Wooster, R., Raymond, F. L., Turner, G. Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation. Clin. Genet. 70: 509-515, 2006.

Other Notes

Small volumes of anti-RPS6KA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RPS6KA3 purchase

MBS1753027 is an antibody targeting RPS6KA3. Also known as Anti-Rsk 2/MAPKAP Kinase 1b/RPS6KA3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RPS6KA3. It may not necessarily be applicable to this product.

NCBI GI #
4759050
NCBI GeneID
6197
NCBI Accession #
NP_004577.1
UniProt Primary Accession #
P51812
UniProt Related Accession #
P51812
GenBank Nucleotide #
NP_004577.1
NCBI Official Full Name
ribosomal protein S6 kinase alpha-3
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A3
NCBI Official Symbol
RPS6KA3
NCBI Official Synonym Symbols
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
UniProt Protein Name
Ribosomal protein S6 kinase alpha-3
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
RPS6KA3
UniProt Synonym Gene Names
ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2
UniProt Entry Name
KS6A3_HUMAN
NCBI Protein Information
ribosomal protein S6 kinase alpha-3

NCBI Summary for RPS6KA3

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
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Research Articles on RPS6KA3

1. The c.966_967delAA (p.Arg323Thr fs*11) deletional mutation of the RPS6KA3 gene probably underlies Coffin-Lowry syndrome in this Chinese pedigree.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RPS6KA3 antibody

 Reference Product  PubMed Publications
 MAPK1 antibody  >2 publications with RPS6KA3 and MAPK1
 ELK1 antibody  >1 publications with RPS6KA3 and ELK1
 MAPK3 antibody  >1 publications with RPS6KA3 and MAPK3

Pathways associated with anti-RPS6KA3 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-RPS6KA3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with RPS6KA3 and Nervous System Diseases
 Coffin-Lowry Syndrome Antibodies  >23 publications with RPS6KA3 and Coffin-Lowry Syndrome
 Disease Models, Animal Antibodies  >5 publications with RPS6KA3 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >5 publications with RPS6KA3 and Congenital Abnormalities
 Brain Diseases Antibodies  >2 publications with RPS6KA3 and Brain Diseases
 Nervous System Malformations Antibodies  >2 publications with RPS6KA3 and Nervous System Malformations
 Carcinoma, Hepatocellular Antibodies  >2 publications with RPS6KA3 and Carcinoma, Hepatocellular
 Neural Tube Defects Antibodies  >1 publications with RPS6KA3 and Neural Tube Defects
 Liver Diseases Antibodies  >1 publications with RPS6KA3 and Liver Diseases
 Learning Disorders Antibodies  >1 publications with RPS6KA3 and Learning Disorders

Organs/Tissues associated with anti-RPS6KA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with RPS6KA3 and Brain
 Bone Antibodies  >3 publications with RPS6KA3 and Bone
 Embryonic Tissue Antibodies  >2 publications with RPS6KA3 and Embryonic Tissue
 Liver Antibodies  >2 publications with RPS6KA3 and Liver
 Ovary Antibodies  >1 publications with RPS6KA3 and Ovary
 Connective Tissue Antibodies  >1 publications with RPS6KA3 and Connective Tissue
 Testis Antibodies  >1 publications with RPS6KA3 and Testis
 Bone Marrow Antibodies  >1 publications with RPS6KA3 and Bone Marrow
 Kidney Antibodies  >1 publications with RPS6KA3 and Kidney
 Muscle Antibodies  >1 publications with RPS6KA3 and Muscle
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