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UGT1A6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753030

Description: Rabbit IgG polyclonal antibody for UGT1A6 detection. Tested with WB, IHC-P, FCM, Direct ELISA in Mouse; Rat.Background: UDP-glucuronosyltransferase 1-6 is an enzyme that in humans is encoded by the UGT1A6 gene. It is mapped to 2q37.1. This gene… More details

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Product Overview

Online Datasheet in PDF
Product Name
UGT1A6, Polyclonal Antibody
Full Product Name
Anti-UGT1A6 Antibody
Product Gene Name
anti-Ugt1a6 antibody
Product Synonym Names
UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; A1; P-nitrophenol-specific UDPGT; UDP-glucuronosyltransferase 1A6; UGT1A6; Ugt1a6; Ugt1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for P08430
Immunogen
E Coli-derived rat UGT1A6 recombinant protein (Position: D26-D238).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Ugt1a6 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-Ugt1a6 antibody
WB: 0.25-0.5ug/ml (Mouse, Rat)
IHC-P (Embedded Section): 0.5-1ug/ml (Rat)
FC/FACS: 1-3ug/1x106 cells (Mouse)
Direct ELISA: 0.1-0.5ug/ml (Rat)
Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.

Flow Cytometry (FC/FACS) of anti-Ugt1a6 antibody

Rabbit Anti-UGT1A6 Polyclonal Antibody – Cat# MBS1753030

Immunohistochemistry (IHC) of anti-Ugt1a6 antibody

Rabbit Anti-UGT1A6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1753030

Western Blot (WB) of anti-Ugt1a6 antibody

Rabbit Anti-UGT1A6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1753030

Product References and Citations for anti-Ugt1a6 antibody

1. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255-69.
2. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257-61.
3. Shrestha B, Reed JM, Starks PT, Kaufman GE, Goldstone JV, Roelke ME, O'Brien SJ, Koepfli KP, Frank LG, Court MH (2011). Zanger U (ed.). "Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory". PLoS One. 6 (3): e18046.

Other Notes

Small volumes of anti-Ugt1a6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ugt1a6 purchase

MBS1753030 is an antibody targeting Ugt1a6. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ugt1a6. It may not necessarily be applicable to this product.

NCBI GI #
89276778
NCBI GeneID
113992
NCBI Accession #
NP_001034780.1
UniProt Primary Accession #
P08430
UniProt Related Accession #
P08430
GenBank Nucleotide #
NP_001034780.1
NCBI Official Full Name
UDP-glucuronosyltransferase 1-6
NCBI Official Synonym Full Names
UDP glucuronosyltransferase family 1 member A6
NCBI Official Symbol
Ugt1a6
NCBI Official Synonym Symbols
Ugt1; Udpgt; Ugt1a7; UDPGT 1-6
UniProt Protein Name
UDP-glucuronosyltransferase 1-6
UniProt Synonym Protein Names
A1; P-nitrophenol-specific UDPGT; UDP-glucuronosyltransferase 1A6
Protein Family
UDP-glucuronosyltransferase
UniProt Gene Name
Ugt1a6
UniProt Synonym Gene Names
Ugt1; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; UGT1A6
UniProt Entry Name
UD16_RAT
NCBI Protein Information
UDP-glucuronosyltransferase 1-6

NCBI Summary for Ugt1a6

catalyzes the glucuronidation of 4-nitrophenol [RGD, Feb 2006]

UniProt Comments for Ugt1a6

Ugt1a6a: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

Protein type: Membrane protein, integral; Mitochondrial; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose

Cellular Component: endoplasmic reticulum membrane; protein complex; intracellular membrane-bound organelle; integral to membrane

Molecular Function: glucuronosyltransferase activity; protein complex binding

Biological Process: response to peptide hormone stimulus; flavonoid biosynthetic process; 4-chlorobiphenyl metabolic process; response to lipopolysaccharide; liver development; response to organic cyclic substance; cellular response to hormone stimulus
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Research Articles on Ugt1a6

1. study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ugt1a6 antibody

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 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies  Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram
 Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies  Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram

Diseases associated with anti-Ugt1a6 antibody

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >64 publications with Ugt1a6 and Drug Toxicity
 Neoplasms Antibodies  >54 publications with Ugt1a6 and Neoplasms
 Liver Diseases Antibodies  >32 publications with Ugt1a6 and Liver Diseases
 Gastrointestinal Diseases Antibodies  >25 publications with Ugt1a6 and Gastrointestinal Diseases
 Liver Neoplasms Antibodies  >22 publications with Ugt1a6 and Liver Neoplasms
 Liver Neoplasms, Experimental Antibodies  >10 publications with Ugt1a6 and Liver Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >8 publications with Ugt1a6 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >7 publications with Ugt1a6 and Inflammation
 Brain Diseases Antibodies  >7 publications with Ugt1a6 and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with Ugt1a6 and Nervous System Diseases

Organs/Tissues associated with anti-Ugt1a6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >258 publications with Ugt1a6 and Liver
 Kidney Antibodies  >43 publications with Ugt1a6 and Kidney
 Colon Antibodies  >30 publications with Ugt1a6 and Colon
 Small Intestine Antibodies  >28 publications with Ugt1a6 and Small Intestine
 Brain Antibodies  >16 publications with Ugt1a6 and Brain
 Ovary Antibodies  >4 publications with Ugt1a6 and Ovary
 Prostate Antibodies  >2 publications with Ugt1a6 and Prostate
 Pancreas Antibodies  >1 publications with Ugt1a6 and Pancreas
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