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Scramblase 1/Plscr1 (PLSCR1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753063

Description: Rabbit IgG polyclonal antibody for Scramblase 1/Plscr1 detection. Tested with WB, IHC-P, Direct ELISA in Human;Mouse.Background: Phospholipid scramblase 1 is a protein that in human is encoded by the PLSCR1 gene. This gene is mapped to 9; 9 E3.3. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Scramblase 1/Plscr1, Polyclonal Antibody
Full Product Name
Anti-Scramblase 1/Plscr1 Antibody
Product Gene Name
anti-Plscr1 antibody
Product Synonym Names
Phospholipid scramblase 1; PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Transplantability-associated protein 1; NOR1; TRA1; Plscr1; Tra1b, Tras1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for Q9JJ00
Immunogen
E Coli-derived mouse Scramblase 1/Plscr1 recombinant protein (Position: M1-Q271).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Plscr1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA)
Application Notes for anti-Plscr1 antibody
WB: 0.1-0.25ug/ml (Human, Mouse)
IHC-P (Embedded Section): 0.5-1ug/ml (Mouse)
Direct ELISA: 0.1-0.5ug/ml (Mouse)
Tested Species: In-house tested species with positive results.

Immunohistochemistry (IHC) of anti-Plscr1 antibody

Rabbit Anti-PLSCR1 Polyclonal Antibody – Cat# MBS1753063

Western Blot (WB) of anti-Plscr1 antibody

Figure 1. Western blot analysis of Plscr1 using anti-Plscr1 antibody.
Rabbit Anti-PLSCR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1753063

Product References and Citations for anti-Plscr1 antibody

1. Basse, F., Stout, J. G., Sims, P. J., Wiedmer, T. Isolation of an erythrocyte membrane protein that mediates Ca(2+)-dependent transbilayer movement of phospholipid. J. Biol. Chem. 271: 17205-17210, 1996.
2. Kametaka, S., Shibata, M., Moroe, K., Kanamori, S., Ohsawa, Y., Waguri, S., Sims, P. J., Emoto, K., Umeda, M., Uchiyama, Y. Identification of phospholipid scramblase 1 as a novel interacting molecule with beta-secretase (beta-site amyloid precursor protein (APP) cleaving enzyme (BACE). J. Biol. Chem. 278: 15239-15245, 2003.
3. Kasukabe, T., Kobayashi, H., Kaneko, Y., Okabe-Kado, J., Honma, Y. Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as a plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene. Biochem. Biophys. Res. Commun. 249: 449-455, 1998.

Other Notes

Small volumes of anti-Plscr1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Plscr1 purchase

MBS1753063 is an antibody targeting Plscr1. Also known as Anti-Scramblase 1/Plscr1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Plscr1. It may not necessarily be applicable to this product.

NCBI GI #
194328695
NCBI GeneID
22038
NCBI Accession #
NP_035766.2
UniProt Primary Accession #
Q9JJ00
UniProt Related Accession #
Q9JJ00
GenBank Nucleotide #
NP_035766.2
NCBI Official Full Name
phospholipid scramblase 1
NCBI Official Synonym Full Names
phospholipid scramblase 1
NCBI Official Symbol
Plscr1
NCBI Official Synonym Symbols
Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2; MmTRA1a; MmTRA1b
UniProt Protein Name
Phospholipid scramblase 1
UniProt Synonym Protein Names
Ca(2+)-dependent phospholipid scramblase 1; Transplantability-associated protein 1; NOR1; TRA1
Protein Family
Phospholipid scramblase
UniProt Gene Name
Plscr1
UniProt Synonym Gene Names
Tra1b; Tras1; PL scramblase 1; NOR1; TRA1
UniProt Entry Name
PLS1_MOUSE
NCBI Protein Information
phospholipid scramblase 1

UniProt Comments for Plscr1

PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.

Protein type: Calcium-binding; Membrane protein, integral

Cellular Component: cytosol; extracellular matrix; Golgi apparatus; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleolus; nucleus; plasma membrane

Molecular Function: calcium ion binding; CD4 receptor binding; DNA binding; enzyme binding; epidermal growth factor receptor binding; phospholipid scramblase activity; SH3 domain binding

Biological Process: apoptosis; defense response to virus; immune response; myeloid cell differentiation; negative regulation of protein binding; negative regulation of viral genome replication; phosphatidylserine biosynthetic process; phospholipid scrambling; positive regulation of apoptosis; positive regulation of innate immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of mast cell activation; transcription from RNA polymerase II promoter
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Research Articles on Plscr1

1. PLSCR1 aggravates anaphylactic reactions by increasing Fc epsion RI-dependent mast cell degranulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Plscr1 antibody

 Reference Product  PubMed Publications
 Src antibody  >9 publications with Plscr1 and Src
 Itpr1 antibody  >1 publications with Plscr1 and Itpr1
 Oxsr1 antibody  >1 publications with Plscr1 and Oxsr1
 Bace1 antibody  >1 publications with Plscr1 and Bace1
 Shc1 antibody  >1 publications with Plscr1 and Shc1

Pathways associated with anti-Plscr1 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-Plscr1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >6 publications with Plscr1 and Liver Diseases
 Inflammation Antibodies  >5 publications with Plscr1 and Inflammation
 Hepatitis Antibodies  >5 publications with Plscr1 and Hepatitis
 Cardiovascular Diseases Antibodies  >5 publications with Plscr1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >4 publications with Plscr1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with Plscr1 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >2 publications with Plscr1 and Brain Diseases
 Necrosis Antibodies  >2 publications with Plscr1 and Necrosis
 Disease Models, Animal Antibodies  >1 publications with Plscr1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with Plscr1 and Breast Neoplasms

Organs/Tissues associated with anti-Plscr1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with Plscr1 and Embryonic Tissue
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