Rabbit Anti-CAMK2A Polyclonal Antibody – Cat# MBS1753074

Camkii Alpha/CAMK2A (CAMK2A) Antibody – Rabbit Polyclonal

Name: CAMK2A Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1753074
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753074

Description: Rabbit IgG polyclonal antibody for CaMKII alpha/CAMK2A detection. Tested with WB, FCM, Direct ELISA in Human; Mouse; Rat.Background: Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIalpha), a.k.a. Ca2+/calmodulin-dependent… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CaMKII alpha/CAMK2A, Polyclonal Antibody

Full Product Name

Anti-CaMKII alpha/CAMK2A Antibody

Product Gene Name

anti-CAMK2A antibody

Product Synonym Names

Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

114078

3D Structure

ModBase 3D Structure for Q9UQM7

Immunogen

E Coli-derived human CaMKII alpha/CAMK2A recombinant protein (Position: M1-H478).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CAMK2A antibody

Western Blot (WB), Flow Cytometry (FC/FACS), Direct ELISA (EIA)

Application Notes for anti-CAMK2A antibody

WB: 0.25-0.5ug/ml (Mouse, Rat)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-CAMK2A antibody

1. Akita, T., Aoto, K., Kato, M., Shiina, M., Mutoh, H., Nakashima, M., Kuki, I., Okazaki, S., Magara, S., Shiihara, T., Yokochi, K., Aiba, K., Tohyama, J., Ohba, C., Miyatake, S., Miyake, N., Ogata, K., Fukuda, A., Matsumoto, N., Saitsu, H. De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. Ann. Clin. Transl. Neurol. 5: 280-296, 2018.
2. Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., Schulman, H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801-805, 2001.
3. Chen, C., Rainnie, D. G., Greene, R. W., Tonegawa, S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294, 1994.

Other Notes

Small volumes of anti-CAMK2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAMK2A purchase

MBS1753074 is an antibody targeting CAMK2A. Also known as Anti-CaMKII alpha/CAMK2A Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMK2A. It may not necessarily be applicable to this product.

NCBI GI #

25952118

NCBI GeneID

815

NCBI Accession #

NP_741960.1

UniProt Primary Accession #

Q9UQM7

UniProt Related Accession #

Q9UQM7

GenBank Nucleotide #

NP_741960.1

NCBI Official Full Name

calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

NCBI Official Synonym Full Names

calcium/calmodulin dependent protein kinase II alpha

NCBI Official Symbol

CAMK2A

NCBI Official Synonym Symbols

CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha

UniProt Protein Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein Family

Calcium/calmodulin-dependent protein kinase

UniProt Gene Name

CAMK2A

UniProt Synonym Gene Names

CAMKA; KIAA0968; CaM kinase II subunit alpha

UniProt Entry Name

KCC2A_HUMAN

NCBI Protein Information

calcium/calmodulin-dependent protein kinase type II subunit alpha

NCBI Summary for CAMK2A

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

UniProt Comments for CAMK2A

CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: nucleoplasm; presynaptic membrane; mitochondrion; plasma membrane; cytosol; cell junction; nucleus

Molecular Function: calmodulin binding; protein serine/threonine kinase activity; glutamate receptor binding; protein binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; kinase activity; ATP binding

Biological Process: synaptic transmission; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; calcium ion transport; cytokine and chemokine mediated signaling pathway; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; G1/S transition of mitotic cell cycle; activation of NF-kappaB transcription factor

Research Articles on CAMK2A

1. CaMK2alpha acts as a key antiapoptosis regulator in metabolic stress-resistant CSCs by activating NFkappaB.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAMK2A antibody

Reference Product	PubMed Publications
CAMK2B antibody	>7 publications with CAMK2A and CAMK2B
CREB1 antibody	>1 publications with CAMK2A and CREB1
GRIN2A antibody	>1 publications with CAMK2A and GRIN2A
GRIN2B antibody	>1 publications with CAMK2A and GRIN2B

Pathways associated with anti-CAMK2A antibody

Products by Pathway	Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies	CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
CREB Phosphorylation Through The Activation Of Ras Pathway antibodies	CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Ca2+ Pathway antibodies	Ca2+ Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram

Diseases associated with anti-CAMK2A antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>48 publications with CAMK2A and Nervous System Diseases
Brain Diseases Antibodies	>32 publications with CAMK2A and Brain Diseases
Seizures Antibodies	>8 publications with CAMK2A and Seizures
Memory Disorders Antibodies	>6 publications with CAMK2A and Memory Disorders
Movement Disorders Antibodies	>6 publications with CAMK2A and Movement Disorders
Learning Disorders Antibodies	>5 publications with CAMK2A and Learning Disorders
Cognition Disorders Antibodies	>4 publications with CAMK2A and Cognition Disorders
Necrosis Antibodies	>3 publications with CAMK2A and Necrosis
Prenatal Exposure Delayed Effects Antibodies	>2 publications with CAMK2A and Prenatal Exposure Delayed Effects
Edema Antibodies	>2 publications with CAMK2A and Edema

Organs/Tissues associated with anti-CAMK2A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>138 publications with CAMK2A and Brain
Muscle Antibodies	>5 publications with CAMK2A and Muscle
Eye Antibodies	>4 publications with CAMK2A and Eye
Embryonic Tissue Antibodies	>4 publications with CAMK2A and Embryonic Tissue
Kidney Antibodies	>4 publications with CAMK2A and Kidney
Heart Antibodies	>3 publications with CAMK2A and Heart