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SORBS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753108

Description: Rabbit IgG polyclonal antibody for SORBS1 detection. Tested with WB, IHC-P, FCM, Direct ELISA in Human.Background: CAP/Ponsinprotein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1… More details

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Product Overview

Online Datasheet in PDF
Product Name
SORBS1, Polyclonal Antibody
Full Product Name
Anti-SORBS1 Antibody
Product Gene Name
anti-SORBS1 antibody
Product Synonym Names
Sorbin and SH3 domain-containing protein 1; Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP; SORBS1; KIAA0894; KIAA1296; SH3D5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
605264
3D Structure
ModBase 3D Structure for Q9BX66
Immunogen
E Coli-derived human SORBS1 recombinant protein (Position: Q23-R323).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SORBS1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-SORBS1 antibody
WB: 0.25-0.5ug/ml (Human)
IHC-P (Embedded Section): 0.5-1ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Flow Cytometry (FC/FACS) of anti-SORBS1 antibody

Rabbit Anti-SORBS1 Polyclonal Antibody – Cat# MBS1753108

Immunohistochemistry (IHC) of anti-SORBS1 antibody

Rabbit Anti-SORBS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1753108

Western Blot (WB) of anti-SORBS1 antibody

Figure 1. Western blot analysis of SORBS1 using anti-SORBS1 antibody.
Rabbit Anti-SORBS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1753108

Product References and Citations for anti-SORBS1 antibody

1. Lin, W.-H., Chiu, K. C., Chang, H.-M., Lee, K.-C., Tai, T.-Y., Chuang, L.-M. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Hum. Molec. Genet. 10: 1753-1760, 2001.
2. Mastick, C. C., Brady, M. J., Saltiel, A. R. Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol. 129: 1523-1531, 1995.
3. Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., Saltiel, A. R. A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molec. Cell. Biol. 18: 872-879, 1998.

Other Notes

Small volumes of anti-SORBS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SORBS1 purchase

MBS1753108 is an antibody targeting SORBS1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SORBS1. It may not necessarily be applicable to this product.

NCBI GI #
7661700
NCBI GeneID
10580
NCBI Accession #
NP_056200.1
UniProt Primary Accession #
Q9BX66
UniProt Related Accession #
Q9BX66
GenBank Nucleotide #
NP_056200.1
NCBI Official Full Name
sorbin and SH3 domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
sorbin and SH3 domain containing 1
NCBI Official Symbol
SORBS1
NCBI Official Synonym Symbols
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12
UniProt Protein Name
Sorbin and SH3 domain-containing protein 1
UniProt Synonym Protein Names
Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
Protein Family
Sorbin and SH3 domain-containing protein
UniProt Gene Name
SORBS1
UniProt Synonym Gene Names
CAP
UniProt Entry Name
SRBS1_HUMAN
NCBI Protein Information
sorbin and SH3 domain-containing protein 1

NCBI Summary for SORBS1

This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

UniProt Comments for SORBS1

SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: centrosome; nuclear matrix; focal adhesion; zonula adherens; cytosol; cell-substrate adherens junction; lipid raft; nucleoplasm; cell-cell adherens junction; cytoplasm; plasma membrane; stress fiber; nucleus

Molecular Function: protein binding; SH3/SH2 adaptor activity; cytoskeletal protein binding; actin binding; protein kinase binding; insulin receptor binding

Biological Process: focal adhesion formation; positive regulation of glucose import; cellular response to insulin stimulus; muscle contraction; positive regulation of signal transduction; cell-matrix adhesion; positive regulation of glycogen biosynthetic process; stress fiber formation; insulin receptor signaling pathway; positive regulation of lipid biosynthetic process; glucose transport
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Research Articles on SORBS1

1. The SORBS1 GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test in Chinese patients.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SORBS1 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-SORBS1 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >9 publications with SORBS1 and Insulin Resistance
 Cardiovascular Diseases Antibodies  >4 publications with SORBS1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with SORBS1 and Inflammation
 Carcinoma Antibodies  >3 publications with SORBS1 and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with SORBS1 and Adenocarcinoma
 Heart Diseases Antibodies  >1 publications with SORBS1 and Heart Diseases
 Nervous System Diseases Antibodies  >1 publications with SORBS1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with SORBS1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with SORBS1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with SORBS1 and Breast Neoplasms

Organs/Tissues associated with anti-SORBS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >9 publications with SORBS1 and Adipose Tissue
 Muscle Antibodies  >7 publications with SORBS1 and Muscle
 Connective Tissue Antibodies  >6 publications with SORBS1 and Connective Tissue
 Heart Antibodies  >4 publications with SORBS1 and Heart
 Liver Antibodies  >3 publications with SORBS1 and Liver
 Bone Antibodies  >2 publications with SORBS1 and Bone
 Ovary Antibodies  >2 publications with SORBS1 and Ovary
 Nerve Antibodies  >1 publications with SORBS1 and Nerve
 Vascular Antibodies  >1 publications with SORBS1 and Vascular
 Embryonic Tissue Antibodies  >1 publications with SORBS1 and Embryonic Tissue
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