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OAS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753114

Description: Rabbit IgG polyclonal antibody for OAS3 detection. Tested with WB, FCM, Direct ELISA in Human.Background: 2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene. It is mapped to 12q24.13. This gene encodes an… More details

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Product Overview

Online Datasheet in PDF
Product Name
OAS3, Polyclonal Antibody
Full Product Name
Anti-OAS3 Antibody
Product Gene Name
anti-OAS3 antibody
Product Synonym Names
2'-5'-oligoadenylate synthase 3; (2-5')oligo(A) synthase 3; 2-5A synthase 3; p100 OAS; p100OAS; OAS3; P/OKcl.4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
603351
3D Structure
ModBase 3D Structure for Q9Y6K5
Immunogen
E Coli-derived human OAS3 recombinant protein (Position: N990-V1087).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-OAS3 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), Direct ELISA (EIA)
Application Notes for anti-OAS3 antibody
WB: 0.1-0.25ug/ml (Human)
FC/FACS: 1-3ug/1x106 cells (Human)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-OAS3 antibody

1. Hovanessian, A. G., Laurent, A. G., Chebath, J., Galabru, J., Robert, N., Svab, J. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J. 6: 1273-1280, 1987.
2. Hovnanian, A., Rebouillat, D., Mattei, M.-G., Levy, E. R., Marie, I., Monaco, A. P., Hovanessian, A. G. The human 2-prime,5-prime-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. Genomics 52: 267-277, 1998.
3. Lin, R.-J., Yu, H.-P., Chang, W.-C., Liao, C.-L., Lin, Y.-L. Distinct antiviral roles for human 2-prime,5-prime-oligoadenylate synthetase family members against Dengue virus infection. J. Immun. 183: 8035-8043, 2009.

Other Notes

Small volumes of anti-OAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OAS3 purchase

MBS1753114 is an antibody targeting OAS3. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OAS3. It may not necessarily be applicable to this product.

NCBI GI #
45007007
NCBI GeneID
4940
NCBI Accession #
NP_006178.2
UniProt Primary Accession #
Q9Y6K5
UniProt Related Accession #
Q9Y6K5
GenBank Nucleotide #
NP_006178.2
NCBI Official Full Name
2'-5'-oligoadenylate synthase 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 3
NCBI Official Symbol
OAS3
NCBI Official Synonym Symbols
p100; p100OAS
UniProt Protein Name
2'-5'-oligoadenylate synthase 3
UniProt Synonym Protein Names
p100 OAS; p100OAS
Protein Family
2'-5'-oligoadenylate synthase
UniProt Gene Name
OAS3
UniProt Synonym Gene Names
(2-5')oligo(A) synthase 3; 2-5A synthase 3; p100OAS
UniProt Entry Name
OAS3_HUMAN
NCBI Protein Information
2'-5'-oligoadenylate synthase 3

NCBI Summary for OAS3

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
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UniProt Comments for OAS3

OAS3: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). Belongs to the 2-5A synthase family.

Protein type: Transferase; EC 2.7.7.84

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: nucleoplasm; extracellular space; intracellular membrane-bound organelle; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: negative regulation of viral genome replication; response to virus; cytokine and chemokine mediated signaling pathway; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; defense response to virus
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Research Articles on OAS3

1. Our study revealed a heterozygous mutation in OAS3 from a Chinese Juvenile-onset open-angle glaucoma family. And this mutation showed a deleterious effect to the expression of OAS3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OAS3 antibody

 Reference Product  PubMed Publications
 OAS1 antibody  >23 publications with OAS3 and OAS1
 OAS2 antibody  >21 publications with OAS3 and OAS2
 OASL antibody  >9 publications with OAS3 and OASL
 ISG15 antibody  >1 publications with OAS3 and ISG15
 MX1 antibody  >1 publications with OAS3 and MX1

Pathways associated with anti-OAS3 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
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 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with anti-OAS3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with OAS3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with OAS3 and Cardiovascular Diseases
 Liver Diseases Antibodies  >2 publications with OAS3 and Liver Diseases
 Atherosclerosis Antibodies  >1 publications with OAS3 and Atherosclerosis
 Hypertension Antibodies  >1 publications with OAS3 and Hypertension
 Prostatic Neoplasms Antibodies  >1 publications with OAS3 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >1 publications with OAS3 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with OAS3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with OAS3 and Liver Neoplasms
 Influenza, Human Antibodies  >1 publications with OAS3 and Influenza, Human
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