SLC25A1 Antibody – Rabbit Polyclonal

Description: Rabbit IgG polyclonal antibody for Slc25a1 detection. Tested with WB, ICC/IF, FCM, Direct ELISA in Human; Mouse; Rat.

Background: Tricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by the SLC25A1 gene. It is mapped to 22q11.21. This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants.

1. Chaouch, A., Porcelli, V., Cox, D., Edvardson, S., Scarcia, P., De Grassi, A., Pierri, C. L., Cossins, J., Laval, S. H., Griffin, H., Muller, J. S., Evangelista, T., and 13 others. Mutations in the mitochondrial citrate carrier SLC25A1 are associated with impaired neuromuscular transmission. J. Neuromusc. Dis. 1: 75-90, 2014.
2. Edvardson, S., Porcelli, V., Jalas, C., Sioferman, D., Kelner, Y., Shaaq, A., Korman, S. H., Pierri, C. L., Scarcia, P., Fraenkel, N. D., Segel, R., Schechter, A., Frumkin, A., Pines, O., Saada, A., Palmieri,., Elpeleg, O. Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter. J. Med. Genet. 50: 240-245, 2013.
3. Goldmuntz, E., Wang, Z., Roe, B. A., Budarf, M. L. Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region. Genomics 33: 271-276, 1996.

Small volumes of anti-SLC25A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1753128 is an antibody targeting SLC25A1. Reactive in Human, Mouse, Rat. Host: Rabbit.