PEBP1 Antibody – Rabbit Polyclonal

RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice.

Protein type: Protein kinase, regulatory subunit; Lipid-binding

Cellular Component: Golgi apparatus; extracellular space; neuron projection; cell surface; rough endoplasmic reticulum; mitochondrion; mitochondrial outer membrane; synaptic vesicle; cell soma; apical part of cell; cytoplasm; nerve terminal; nucleus; myelin sheath

Molecular Function: serine-type endopeptidase inhibitor activity; enzyme binding; protease inhibitor activity; nucleotide binding; mitogen-activated protein kinase binding; lipid binding; kinase binding; protein kinase binding; ATP binding; receptor binding

Biological Process: positive regulation of mitosis; negative regulation of protein amino acid phosphorylation; negative regulation of MAPKKK cascade; regulation of neurotransmitter levels; MAPKKK cascade; negative regulation of peptidase activity; regulation of the force of heart contraction; sperm capacitation