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TFPI2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175398

Description: Rabbit IgG polyclonal antibody for Tissue factor pathway inhibitor 2(TFPI2) detection. Tested with WB, IHC-P in Human.Background: Tissue factor pathway inhibitor 2, also known as TFPI2, is a human gene which is located at 7q22. It is an important… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TFPI2, Polyclonal Antibody
Full Product Name
Anti-TFPI2 antibody
Product Gene Name
anti-TFPI2 antibody
Product Synonym Names
Tissue factor pathway inhibitor 2(TFPI-2); tissue factor pathway inhibitor 2; Placental protein 5 antibody; PP5 antibody; TFPI 2 antibody; TFPI-2 antibody; TFPI2 antibody; TFPI2 PEN antibody; TFPI2_HUMAN antibody; Tissue factor pathway inhibitor 2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
25,796 Da
OMIM
600033
3D Structure
ModBase 3D Structure for P48307
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human TFPI2 (170-186aa NVTRYYFNPRYRTCDAF).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TFPI2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-TFPI2 antibody
Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu
Immuohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Tested Species: Hu
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.

Western Blot (WB) of anti-TFPI2 antibody

Anti-TFPI2 antibody, MBS175398, Western blotting
Lane 1: MM453 Cell Lysate
Lane 2: MM231 Cell Lysate
Lane 3: HELA Cell Lysate
Lane 4: HT1080 Cell Lysate
Lane 5: JURKAT Cell Lysate
Rabbit Anti-TFPI2 Polyclonal Antibody – Cat# MBS175398

Immunohistochemistry (IHC) of anti-TFPI2 antibody

Anti-TFPI2 antibody, MBS175398, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-TFPI2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175398

Other Notes

Small volumes of anti-TFPI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFPI2 purchase

MBS175398 is an antibody targeting TFPI2. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TFPI2. It may not necessarily be applicable to this product.

NCBI GI #
1351226
NCBI GeneID
7980
NCBI Accession #
P48307.1
UniProt Primary Accession #
P48307
UniProt Secondary Accession #
Q66ME8; Q8NAK6; Q9UC86
UniProt Related Accession #
P48307
NCBI Official Full Name
Tissue factor pathway inhibitor 2
NCBI Official Synonym Full Names
tissue factor pathway inhibitor 2
NCBI Official Symbol
TFPI2
NCBI Official Synonym Symbols
PP5; REF1; TFPI-2
UniProt Protein Name
Tissue factor pathway inhibitor 2
UniProt Synonym Protein Names
Placental protein 5; PP5
Protein Family
Tissue factor pathway inhibitor
UniProt Gene Name
TFPI2
UniProt Synonym Gene Names
TFPI-2; PP5
UniProt Entry Name
TFPI2_HUMAN
NCBI Protein Information
tissue factor pathway inhibitor 2; placental protein 5; retinal pigment epithelium cell factor 1

NCBI Summary for TFPI2

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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UniProt Comments for TFPI2

TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: proteinaceous extracellular matrix; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; extracellular matrix structural constituent

Biological Process: blood coagulation
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Research Articles on TFPI2

1. TFPI2 is a novel serum marker for ovarian clear cell adenocarcinoma and neoplastic transformation from endometriosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFPI2 antibody

 Reference Product  PubMed Publications
 TMPRSS4 antibody  >1 publications with TFPI2 and TMPRSS4
 IL1B antibody  >1 publications with TFPI2 and IL1B

Diseases associated with anti-TFPI2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >20 publications with TFPI2 and Carcinoma
 Colorectal Neoplasms Antibodies  >13 publications with TFPI2 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >8 publications with TFPI2 and Adenocarcinoma
 Inflammation Antibodies  >6 publications with TFPI2 and Inflammation
 Pancreatic Neoplasms Antibodies  >6 publications with TFPI2 and Pancreatic Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with TFPI2 and Neoplasm Metastasis
 Melanoma Antibodies  >4 publications with TFPI2 and Melanoma
 Skin Neoplasms Antibodies  >3 publications with TFPI2 and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with TFPI2 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >2 publications with TFPI2 and Ovarian Neoplasms

Organs/Tissues associated with anti-TFPI2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with TFPI2 and Blood
 Stomach Antibodies  >5 publications with TFPI2 and Stomach
 Liver Antibodies  >5 publications with TFPI2 and Liver
 Embryonic Tissue Antibodies  >5 publications with TFPI2 and Embryonic Tissue
 Placenta Antibodies  >5 publications with TFPI2 and Placenta
 Skin Antibodies  >4 publications with TFPI2 and Skin
 Bone Antibodies  >4 publications with TFPI2 and Bone
 Uterus Antibodies  >3 publications with TFPI2 and Uterus
 Pancreas Antibodies  >3 publications with TFPI2 and Pancreas
 Vascular Antibodies  >3 publications with TFPI2 and Vascular
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