Rabbit Anti-ABCC1 Polyclonal Antibody – Cat# MBS175406

Anti-MRP1 antibody, MBS175406, Western blotting
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ABCC1 Antibody – Rabbit Polyclonal

Name: ABCC1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS175406
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175406

ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1), also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette(ABC) transporters. The ABCC1 is a plasma membrane… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MRP1 (ABCC1), Polyclonal Antibody

Full Product Name

Anti-MRP1 antibody

Product Gene Name

anti-ABCC1 antibody

Product Synonym Names

Multidrug resistance-associated protein 1; ATP-binding cassette, sub-family C(CFTR/MRP), member 1; ABC 29 antibody; ABC29 antibody; ABCC 1 antibody; ABCC antibody; ABCC1 antibody; ATP binding cassette sub family C(CFTR/MRP) member 1 antibody; ATP binding cassette sub-family C member 1 antibody; ATP-binding cassette sub-family C member 1 antibody; DKFZp686N04233 antibody; DKFZp781G125 antibody; GS X antibody; GSX antibody; Leukotriene C(4) transporter antibody; LTC4 transporter antibody; MRP 1 antibody; MRP antibody; MRP1_HUMAN antibody; Multidrug resistance associated protein 1 antibody; Multidrug resistance protein antibody; Multidrug resistance-associated protein 1 antibody; Multiple drug resistance associated protein antibody; Multiple drug resistance protein 1 antibody

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat. No cross reactivity with other proteins.

Form/Format

Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg Thimerosal, 0.05mg NaN₃.

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

OMIM

158343

3D Structure

ModBase 3D Structure for P33527

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1 (1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.

Reconstitution

0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-ABCC1 antibody

Western Blot (WB), Immunohistochemistry (IHC) (Paraffin-embedded Section)

Application Notes for anti-ABCC1 antibody

Western blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Human, Rat
Concluded Species: Mouse
Antigen Retrieval: -

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml/ml
Tested Species: Human
Predicted Species: Mouse, Rat
Antigen Retrieval: By Heat

Other applications have not been tested.
Optimal dilutions should be determined by end users.

Other Notes

Small volumes of anti-ABCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABCC1 purchase

MBS175406 is an antibody targeting ABCC1. Also known as Anti-MRP1 antibody. Reactive in Human, Mouse, Rat. No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCC1. It may not necessarily be applicable to this product.

NCBI GI #

296439301

NCBI GeneID

4363

NCBI Accession #

P33527.3

UniProt Primary Accession #

P33527

UniProt Secondary Accession #

O14819; O43333; P78419; Q59GI9; Q9UQ97; Q9UQ99; Q9UQA0; A3RJX2; C9JPJ4

UniProt Related Accession #

P33527

NCBI Official Full Name

Multidrug resistance-associated protein 1

NCBI Official Synonym Full Names

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

NCBI Official Symbol

ABCC1

NCBI Official Synonym Symbols

MRP; ABCC; GS-X; MRP1; ABC29

UniProt Protein Name

Multidrug resistance-associated protein 1

UniProt Synonym Protein Names

ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter

Protein Family

ABC transporter C family

UniProt Gene Name

ABCC1

UniProt Synonym Gene Names

MRP; MRP1; LTC4 transporter

UniProt Entry Name

MRP1_HUMAN

NCBI Protein Information

multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25&26

NCBI Summary for ABCC1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

UniProt Comments for ABCC1

ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding

Biological Process: response to drug; vitamin metabolic process; cobalamin metabolic process; transport; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process

Research Articles on ABCC1

1. ABCC1/MRP1 expression shows robust prognostic relevance in patients with localized high-risk soft tissue sarcomas treated with anthracycline-based chemotherapy, which is the standard front line treatment in soft tissue sarcomas .

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ABCC1 antibody

Products by Pathway	Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies	Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective BTD Causes Biotidinase Deficiency Pathway antibodies	Defective BTD Causes Biotidinase Deficiency Pathway Diagram
Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies	Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies	Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram

Diseases associated with anti-ABCC1 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>44 publications with ABCC1 and Breast Neoplasms
Lung Neoplasms Antibodies	>28 publications with ABCC1 and Lung Neoplasms
Brain Diseases Antibodies	>27 publications with ABCC1 and Brain Diseases
Adenocarcinoma Antibodies	>27 publications with ABCC1 and Adenocarcinoma
Nervous System Diseases Antibodies	>27 publications with ABCC1 and Nervous System Diseases
Liver Diseases Antibodies	>23 publications with ABCC1 and Liver Diseases
Disease Models, Animal Antibodies	>20 publications with ABCC1 and Disease Models, Animal
Ovarian Neoplasms Antibodies	>16 publications with ABCC1 and Ovarian Neoplasms
Liver Neoplasms Antibodies	>15 publications with ABCC1 and Liver Neoplasms
Colorectal Neoplasms Antibodies	>13 publications with ABCC1 and Colorectal Neoplasms

Organs/Tissues associated with anti-ABCC1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>127 publications with ABCC1 and Blood
Brain Antibodies	>72 publications with ABCC1 and Brain
Liver Antibodies	>65 publications with ABCC1 and Liver
Lung Antibodies	>55 publications with ABCC1 and Lung
Kidney Antibodies	>45 publications with ABCC1 and Kidney
Vascular Antibodies	>23 publications with ABCC1 and Vascular
Intestine Antibodies	>22 publications with ABCC1 and Intestine
Testis Antibodies	>15 publications with ABCC1 and Testis
Skin Antibodies	>13 publications with ABCC1 and Skin
Placenta Antibodies	>12 publications with ABCC1 and Placenta