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HSPD1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175435

Description: Rabbit IgG polyclonal antibody for 60 kDa heat shock protein, mitochondrial(HSPD1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.Background: HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSP60 (HSPD1), Polyclonal Antibody
Full Product Name
Anti-HSP60 antibody
Product Gene Name
anti-HSPD1 antibody
Product Synonym Names
60 kDa heat shock protein, mitochondrial; heat shock 60kDa protein 1(chaperonin); 60 kDa chaperonin antibody; 60 kDa heat shock protein mitochondrial antibody; 60 kDa heat shock protein, mitochondrial antibody; CH60_HUMAN antibody; Chaperonin 60 antibody; Chaperonin antibody; Chaperonin, 60-KD antibody; CPN 60 antibody; CPN60 antibody; fa04a05 antibody; GROEL antibody; GroEL Homolog antibody; Heat shock 60kD protein 1 chaperonin antibody; Heat shock 60kDa protein 1 antibody; Heat shock protein 1(chaperonin) antibody; Heat Shock Protein 60 antibody; Heat shock protein 65 antibody; HLD4 antibody; Hsp 60 antibody; HSP 65 antibody; HSP-60 antibody; HSP60 antibody; HSP65 antibody; HSPD 1 antibody; HSPD1 antibody; HuCHA60 antibody; Mitochondrial matrix protein P1 antibody; P60 lymphocyte protein antibody; Short heat shock protein 60 Hsp60s1 antibody; Spastic paraplegia 13 antibody; SPG 13 antibody; SPG13 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
60,955 Da
3D Structure
ModBase 3D Structure for P63039
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of rat HSP60 (503-516aa YDAMLGDFVNMVEK), different from the related human sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-HSPD1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Western Blot (WB) of anti-HSPD1 antibody

Anti-HSP60 antibody, MBS175435, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Liver Tissue Lysate
Lane 3: CEM Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: SMMC Cell Lysate
Lane 6: COLO320 Cell Lysate
Rabbit Anti-HSPD1 Polyclonal Antibody – Cat# MBS175435

Immunohistochemistry (IHC) of anti-HSPD1 antibody

Anti-HSP60 antibody, MBS175435, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-HSPD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175435

Immunocytochemistry (ICC) of anti-HSPD1 antibody

Anti-HSP60 antibody, MBS175435, ICC
ICC: SMMC Cell
Rabbit Anti-HSPD1 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175435

Other Notes

Small volumes of anti-HSPD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPD1 purchase

MBS175435 is an antibody targeting HSPD1. Also known as Anti-HSP60 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPD1. It may not necessarily be applicable to this product.

NCBI GI #
51702230
NCBI GeneID
63868
NCBI Accession #
P63039.1
UniProt Primary Accession #
P63039
UniProt Secondary Accession #
P19226; P19227; P97602
UniProt Related Accession #
P63039
NCBI Official Full Name
60 kDa heat shock protein, mitochondrial
NCBI Official Synonym Full Names
heat shock protein 1 (chaperonin)
NCBI Official Symbol
Hspd1
NCBI Official Synonym Symbols
Hsp60; Hspd1-30p
UniProt Protein Name
60 kDa heat shock protein, mitochondrial
UniProt Synonym Protein Names
60 kDa chaperonin; Chaperonin 60; CPN60; HSP-65; Heat shock protein 60; HSP-60; Hsp60; Mitochondrial matrix protein P1
Protein Family
60 kDa heat shock protein
UniProt Gene Name
Hspd1
UniProt Synonym Gene Names
Hsp60; CPN60; HSP-60; Hsp60
UniProt Entry Name
CH60_RAT
NCBI Protein Information
60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSP-65; chaperonin 60; 60 kDa chaperonin; heat shock 60kDa protein 1; heat shock protein 60 (liver); mitochondrial matrix protein P1; heat shock 60kD protein 1 (chaperonin)

NCBI Summary for HSPD1

a stress-inducible molecular chaperone which participates in protein folding [RGD, Feb 2006]

UniProt Comments for HSPD1

HSP60: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family.

Protein type: Chaperone; Mitochondrial

Cellular Component: Golgi apparatus; extracellular space; protein complex; cell surface; rough endoplasmic reticulum; intracellular membrane-bound organelle; mitochondrion; early endosome; coated pit; cytosol; lipid raft; secretory granule; mitochondrial crista; membrane; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; cyclin-dependent protein kinase activating kinase holoenzyme complex; myelin sheath

Molecular Function: insulin binding; protein binding; protease binding; protein heterodimerization activity; lipopolysaccharide binding; p53 binding; chaperone binding; ubiquitin protein ligase binding; double-stranded RNA binding; protein complex binding; misfolded protein binding; ATP binding

Biological Process: B cell proliferation; T cell activation; positive regulation of apoptosis; positive regulation of interleukin-12 production; isotype switching to IgG isotypes; response to lipopolysaccharide; response to organic cyclic substance; positive regulation of interleukin-10 production; response to organic substance; protein refolding; negative regulation of neuron apoptosis; positive regulation of T cell mediated immune response to tumor cell; positive regulation of interferon-alpha production; positive regulation of macrophage activation; caspase activation; response to drug; B cell activation; chaperone cofactor-dependent protein folding; protein stabilization; positive regulation of interleukin-6 production; B cell cytokine production; detection of misfolded protein; response to cocaine; response to unfolded protein; response to ATP; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; 'de novo' protein folding; response to hydrogen peroxide; response to estrogen stimulus; response to heat; response to hypoxia; positive regulation of T cell activation; negative regulation of apoptosis; positive regulation of inflammatory response
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Research Articles on HSPD1

1. HSF-1 protein levels did not simultaneously increase, indicating that HSF-1 is not the sole regulator of Hsp60 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSPD1 antibody

 Products by Pathway  Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram

Diseases associated with anti-HSPD1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with HSPD1 and Cardiovascular Diseases
 Inflammation Antibodies  >13 publications with HSPD1 and Inflammation
 Disease Models, Animal Antibodies  >12 publications with HSPD1 and Disease Models, Animal
 Carcinoma Antibodies  >11 publications with HSPD1 and Carcinoma
 Brain Diseases Antibodies  >11 publications with HSPD1 and Brain Diseases
 Heart Diseases Antibodies  >8 publications with HSPD1 and Heart Diseases
 Atherosclerosis Antibodies  >7 publications with HSPD1 and Atherosclerosis
 Necrosis Antibodies  >6 publications with HSPD1 and Necrosis
 Lung Diseases Antibodies  >5 publications with HSPD1 and Lung Diseases
 Adenocarcinoma Antibodies  >5 publications with HSPD1 and Adenocarcinoma

Organs/Tissues associated with anti-HSPD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with HSPD1 and Brain
 Muscle Antibodies  >10 publications with HSPD1 and Muscle
 Heart Antibodies  >8 publications with HSPD1 and Heart
 Liver Antibodies  >7 publications with HSPD1 and Liver
 Kidney Antibodies  >6 publications with HSPD1 and Kidney
 Embryonic Tissue Antibodies  >4 publications with HSPD1 and Embryonic Tissue
 Lung Antibodies  >4 publications with HSPD1 and Lung
 Prostate Antibodies  >3 publications with HSPD1 and Prostate
 Connective Tissue Antibodies  >3 publications with HSPD1 and Connective Tissue
 Pancreas Antibodies  >2 publications with HSPD1 and Pancreas
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