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CXCL10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175477

Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 10(CXCL10) detection. Tested with WB, IHC-P in Human.Background: C-X-C motif chemokine 10(CXCL10), also known as Interferon gamma-induced protein 10 kDa(IP-10) or small-inducible cytokine… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IP10 (CXCL10), Polyclonal Antibody
Full Product Name
Anti-IP10 antibody
Product Gene Name
anti-CXCL10 antibody
Product Synonym Names
C-X-C motif chemokine 10; chemokine(C-X-C motif) ligand 10; 10 kDa interferon gamma induced protein antibody; 10 kDa interferon gamma-induced protein antibody; C X C motif chemokine 10 antibody; C7 antibody; Chemokine(C X C motif) ligand 10 antibody; Chemokine CXC motif ligand 10 antibody; Crg 2 antibody; CRG2 antibody; CXCL 10 antibody; CXCL10 antibody; CXCL10(1-73) antibody; CXL10_HUMAN antibody; Gamma IP10 antibody; Gamma-IP10 antibody; gIP 10 antibody; GIP10 antibody; IFI 10 antibody; IFI10 antibody; INP 10 antibody; INP10 antibody; Interferon activated gene 10 antibody; Interferon gamma induced cell line antibody; Interferon inducible cytokine IP 10 antibody; Interferon inducible cytokine IP10 antibody; IP 10 antibody; IP-10 antibody; Mob 1 antibody; MOB1 antibody; Protein 10 from interferon(gamma) induced cell line antibody; SCYB 10 antibody; SCYB10 antibody; Small inducible cytokine B10 antibody; Small inducible cytokine B10 precursor antibody; Small inducible cytokine subfamily B(Cys X Cys) member 10 antibody; Small inducible cytokine subfamily B CXC member 10 antibody; Small-inducible cytokine B10 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
10,881 Da
OMIM
147310
3D Structure
ModBase 3D Structure for P02778
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CXCL10 (79-98aa SKAIKNLLKAVSKERSKRSP).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CXCL10 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CXCL10 antibody
Western Blot (WB)
Concentration: 0.1-0.5ug/ml
Tested Species: Hu

Immunohistochemistry (IHC):
Concentration: 0.5-1ug/ml
Tested Species: Hu
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predict Species: Species predicted to be fit for the product based on sequence similarities.
By heat: Boiling the pearaffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin section.
Other applications have not been tested.
Optimal dilutions should be determined by end users.

Western Blot (WB) of anti-CXCL10 antibody

Anti-IP10 antibody, MBS175477, Western blotting
Lane 1: Recombinant Human CXCL10 Protein 10ng
Lane 2: Recombinant Human CXCL10 Protein 5ng
Lane 3: Recombinant Human CXCL10 Protein 2.5ng
Rabbit Anti-CXCL10 Polyclonal Antibody – Cat# MBS175477

Immunohistochemistry (IHC) of anti-CXCL10 antibody

Anti-IP10 antibody, MBS175477, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-CXCL10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175477

Other Notes

Small volumes of anti-CXCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL10 purchase

MBS175477 is an antibody targeting CXCL10. Also known as Anti-IP10 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL10. It may not necessarily be applicable to this product.

NCBI GI #
21542456
NCBI GeneID
3627
NCBI Accession #
P02778.2
UniProt Primary Accession #
P02778
UniProt Secondary Accession #
Q96QJ5
UniProt Related Accession #
P02778
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
CXCL10
NCBI Official Synonym Symbols
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10Cleaved into the following chain:CXCL10(1-73)
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL10
UniProt Synonym Gene Names
INP10; SCYB10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_HUMAN
NCBI Protein Information
C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10

NCBI Summary for CXCL10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
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UniProt Comments for CXCL10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; response to cold; positive regulation of release of sequestered calcium ion into cytosol; regulation of protein kinase activity; inflammatory response; negative regulation of myoblast differentiation; defense response to virus
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Research Articles on CXCL10

1. We have identified previously uncharacterized p65 post-translational modifications critical for CXCL10 induction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL10 antibody

 Reference Product  PubMed Publications
 CXCL9 antibody  >881 publications with CXCL10 and CXCL9
 CXCR3 antibody  >803 publications with CXCL10 and CXCR3
 CCL5 antibody  >623 publications with CXCL10 and CCL5
 CXCL11 antibody  >446 publications with CXCL10 and CXCL11
 CCR5 antibody  >169 publications with CXCL10 and CCR5
 CCL20 antibody  >104 publications with CXCL10 and CCL20
 CCL11 antibody  >97 publications with CXCL10 and CCL11
 CXCR2 antibody  >49 publications with CXCL10 and CXCR2
 CCR3 antibody  >47 publications with CXCL10 and CCR3
 CCR1 antibody  >46 publications with CXCL10 and CCR1

Pathways associated with anti-CXCL10 antibody

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-CXCL10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1108 publications with CXCL10 and Inflammation
 Necrosis Antibodies  >644 publications with CXCL10 and Necrosis
 Lung Diseases Antibodies  >318 publications with CXCL10 and Lung Diseases
 Liver Diseases Antibodies  >216 publications with CXCL10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >161 publications with CXCL10 and Cardiovascular Diseases
 Fibrosis Antibodies  >122 publications with CXCL10 and Fibrosis
 Neoplasms, Experimental Antibodies  >110 publications with CXCL10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >83 publications with CXCL10 and Kidney Diseases
 Lung Injury Antibodies  >61 publications with CXCL10 and Lung Injury
 Pneumonia Antibodies  >59 publications with CXCL10 and Pneumonia

Organs/Tissues associated with anti-CXCL10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1945 publications with CXCL10 and Blood
 Lung Antibodies  >434 publications with CXCL10 and Lung
 Liver Antibodies  >257 publications with CXCL10 and Liver
 Kidney Antibodies  >171 publications with CXCL10 and Kidney
 Lymph Node Antibodies  >154 publications with CXCL10 and Lymph Node
 Muscle Antibodies  >116 publications with CXCL10 and Muscle
 Intestine Antibodies  >87 publications with CXCL10 and Intestine
 Nerve Antibodies  >58 publications with CXCL10 and Nerve
 Uterus Antibodies  >32 publications with CXCL10 and Uterus
 Placenta Antibodies  >26 publications with CXCL10 and Placenta
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