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Kallikrein 11 (KLK11) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175534

Description: Rabbit IgG polyclonal antibody for Kallikrein-11(KLK11) detection. Tested with WB, IHC-P in Human.Background: KLK11(KALLIKREIN 11), also called PRSS20 or TLSP, is a protein that in humans is encoded by the KLK11 gene. KLK11 is a member of the… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Kallikrein 11 (KLK11), Polyclonal Antibody
Full Product Name
Anti-Kallikrein 11 antibody
Product Gene Name
anti-KLK11 antibody
Product Synonym Names
Kallikrein-11(hK11); kallikrein-related peptidase 11; Hippostasin antibody; hK11 antibody; Kallikrein 11 antibody; Kallikrein 11 isoform 1 preproprotein antibody; Kallikrein 11 isoform 2 precursor antibody; Kallikrein 11 precursor antibody; Kallikrein related peptidase 11 antibody; Kallikrein-11 inactive chain 2 antibody; KLK 11 antibody; Klk11 antibody; KLK11_HUMAN antibody; MGC33060 antibody; Protease serine 20 trypsin like antibody; Protease serine trypsin like antibody; PRSS20 antibody; Serine protease 20 antibody; TLSP antibody; Trypsin like protease antibody; Trypsin-like protease antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
30,166 Da
OMIM
604434
3D Structure
ModBase 3D Structure for Q9UBX7
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 11 (233-250aa YTKVCKYVDWIQETMKNN).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-KLK11 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-KLK11 antibody

Anti-Kallikrein 11 antibody, MBS175534, Western blotting
All lanes: Anti Kallikrein 11 (MBS175534) at 0.5ug/ml
Lane 1: U87 Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Lane 3: HELA Whole Cell Lysate at 40ug
Lane 4: MM231 Whole Cell Lysate at 40ug
Lane 5: MM453 Whole Cell Lysate at 40ug
Lane 6: COLO320 Whole Cell Lysate at 40ug
Lane 7: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 31KD
Observed bind size: 31KD
Rabbit Anti-KLK11 Polyclonal Antibody – Cat# MBS175534

Immunohistochemistry (IHC) of anti-KLK11 antibody

Anti-Kallikrein 11 antibody, MBS175534, IHC(P)
IHC(P): Human Prostatic Cancer Tissue
Rabbit Anti-KLK11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175534

Other Notes

Small volumes of anti-KLK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK11 purchase

MBS175534 is an antibody targeting KLK11. Also known as Anti-Kallikrein 11 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK11. It may not necessarily be applicable to this product.

NCBI GI #
88984315
NCBI GeneID
11012
NCBI Accession #
Q9UBX7.2
UniProt Primary Accession #
Q9UBX7
UniProt Secondary Accession #
O75837; Q0WXX5; Q8IXD7; Q9NS65
UniProt Related Accession #
Q9UBX7
NCBI Official Full Name
Kallikrein-11
NCBI Official Synonym Full Names
kallikrein-related peptidase 11
NCBI Official Symbol
KLK11
NCBI Official Synonym Symbols
TLSP; PRSS20
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like proteaseCleaved into the following 2 chains:Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2
Protein Family
Kallikrein
UniProt Gene Name
KLK11
UniProt Synonym Gene Names
PRSS20; TLSP; hK11
UniProt Entry Name
KLK11_HUMAN
NCBI Protein Information
kallikrein-11; hK11; hippostasin; kallikrein 11; serine protease 20; trypsin-like protease

NCBI Summary for KLK11

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]
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UniProt Comments for KLK11

KLK11: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; EC 3.4.21.-; Secreted

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: Golgi apparatus; extracellular space

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis
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Research Articles on KLK11

1. hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLK11 antibody

 Reference Product  PubMed Publications
 KLK10 antibody  >10 publications with KLK11 and KLK10

Diseases associated with anti-KLK11 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >6 publications with KLK11 and Neoplasms, Experimental
 Lung Diseases Antibodies  >6 publications with KLK11 and Lung Diseases
 Adenocarcinoma Antibodies  >5 publications with KLK11 and Adenocarcinoma
 Breast Neoplasms Antibodies  >4 publications with KLK11 and Breast Neoplasms
 Hyperplasia Antibodies  >4 publications with KLK11 and Hyperplasia
 Ovarian Neoplasms Antibodies  >4 publications with KLK11 and Ovarian Neoplasms
 Thrombosis Antibodies  >1 publications with KLK11 and Thrombosis
 Necrosis Antibodies  >1 publications with KLK11 and Necrosis
 Vascular Diseases Antibodies  >1 publications with KLK11 and Vascular Diseases
 Endometrial Neoplasms Antibodies  >1 publications with KLK11 and Endometrial Neoplasms

Organs/Tissues associated with anti-KLK11 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >15 publications with KLK11 and Prostate
 Skin Antibodies  >8 publications with KLK11 and Skin
 Lung Antibodies  >8 publications with KLK11 and Lung
 Brain Antibodies  >5 publications with KLK11 and Brain
 Stomach Antibodies  >2 publications with KLK11 and Stomach
 Trachea Antibodies  >1 publications with KLK11 and Trachea
 Mammary Gland Antibodies  >1 publications with KLK11 and Mammary Gland
 Uterus Antibodies  >1 publications with KLK11 and Uterus
 Ovary Antibodies  >1 publications with KLK11 and Ovary
 Testis Antibodies  >1 publications with KLK11 and Testis
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