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TNFAIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175592

Description: Rabbit IgG polyclonal antibody for BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2(TNFAIP1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.Background: Tumor necrosis factor, alpha-induced protein… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TNFAIP1, Polyclonal Antibody
Full Product Name
Anti-TNFAIP1 antibody
Product Gene Name
anti-TNFAIP1 antibody
Product Synonym Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2(hBACURD2); tumor necrosis factor, alpha-induced protein 1(endothelial); BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
24,709 Da
OMIM
191161
3D Structure
ModBase 3D Structure for Q13829
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TNFAIP1 (27-52aa NKYVQLNVGGSLYYTTVRALTRHDTM), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TNFAIP1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

Western Blot (WB) of anti-TNFAIP1 antibody

Anti-TNFAIP1 antibody, MBS175592, Western blotting
All lanes: Anti TNFAIP1(MBS175592) at 0.5ug/ml
Lane 1: Rat Thymus Tissue Lysate at 50ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: COLO320 Whole Cell Lysate at 40ug
Predicted bind size: 36KD
Observed bind size: 36KD
Rabbit Anti-TNFAIP1 Polyclonal Antibody – Cat# MBS175592

Immunohistochemistry (IHC) of anti-TNFAIP1 antibody

Anti-TNFAIP1 antibody, MBS175592, IHC(P)
IHC(P): Human Rectal Cancer Tissue
Rabbit Anti-TNFAIP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175592

Immunocytochemistry (ICC) of anti-TNFAIP1 antibody

Anti-TNFAIP1 antibody, MBS175592, ICC
ICC: HELA Cell
Rabbit Anti-TNFAIP1 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175592

Other Notes

Small volumes of anti-TNFAIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFAIP1 purchase

MBS175592 is an antibody targeting TNFAIP1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFAIP1. It may not necessarily be applicable to this product.

NCBI GI #
2833248
NCBI GeneID
7126
NCBI Accession #
Q13829.1
UniProt Primary Accession #
Q13829
UniProt Secondary Accession #
Q5TZQ1; B7Z6M4
UniProt Related Accession #
Q13829
NCBI Official Full Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
NCBI Official Synonym Full Names
tumor necrosis factor, alpha-induced protein 1 (endothelial)
NCBI Official Symbol
TNFAIP1
NCBI Official Synonym Symbols
B12; B61; EDP1; BTBD34; hBACURD2
UniProt Protein Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
UniProt Synonym Protein Names
BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial
Protein Family
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein
UniProt Gene Name
TNFAIP1
UniProt Synonym Gene Names
BACURD2; EDP1; hBACURD2
UniProt Entry Name
BACD2_HUMAN
NCBI Protein Information
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1

NCBI Summary for TNFAIP1

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
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UniProt Comments for TNFAIP1

TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family.

Protein type: Ubiquitin conjugating system; DNA replication

Chromosomal Location of Human Ortholog: 17q22-q23

Cellular Component: cytoplasm; nucleolus; endosome

Molecular Function: protein domain specific binding; protein binding; GTP-Rho binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; embryonic development; cell migration; negative regulation of Rho protein signal transduction; apoptosis; stress fiber formation; protein ubiquitination; immune response; DNA replication; positive regulation of DNA replication; protein homooligomerization
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Research Articles on TNFAIP1

1. Expression of TNFAIP1 is regulated by the transcriptional factor Sp1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFAIP1 antibody

 Reference Product  PubMed Publications
 RHOB antibody  >2 publications with TNFAIP1 and RHOB
 KCTD13 antibody  >1 publications with TNFAIP1 and KCTD13

Diseases associated with anti-TNFAIP1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >17 publications with TNFAIP1 and Necrosis
 Inflammation Antibodies  >4 publications with TNFAIP1 and Inflammation
 Brain Diseases Antibodies  >2 publications with TNFAIP1 and Brain Diseases
 Urologic Diseases Antibodies  >1 publications with TNFAIP1 and Urologic Diseases
 Liver Diseases Antibodies  >1 publications with TNFAIP1 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with TNFAIP1 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with TNFAIP1 and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with TNFAIP1 and Fatty Liver
 Diabetic Nephropathies Antibodies  >1 publications with TNFAIP1 and Diabetic Nephropathies

Organs/Tissues associated with anti-TNFAIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with TNFAIP1 and Blood
 Brain Antibodies  >4 publications with TNFAIP1 and Brain
 Liver Antibodies  >3 publications with TNFAIP1 and Liver
 Kidney Antibodies  >1 publications with TNFAIP1 and Kidney
 Stomach Antibodies  >1 publications with TNFAIP1 and Stomach
 Embryonic Tissue Antibodies  >1 publications with TNFAIP1 and Embryonic Tissue
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