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Decorin (DCN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175601

Description: Rabbit IgG polyclonal antibody for Decorin(DCN) detection. Tested with WB in Human, Mouse, Rat.Background: Decorin is a proteoglycan on average 90-140 kilodaltons(kD) in size. The human decorin gene spans more than 38 kb and contains 8 exons and… More details

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Product Overview

Online Datasheet in PDF
Product Name
Decorin (DCN), Polyclonal Antibody
Full Product Name
Anti-Decorin antibody
Product Gene Name
anti-DCN antibody
Product Synonym Names
Decorin; decorin; Bone proteoglycan II antibody; CSCD antibody; DCN antibody; DCN protein antibody; Decorin antibody; Decorin proteoglycan antibody; Dermatan sulphate proteoglycans II antibody; DKFZp686J19238 antibody; DSPG 2 antibody; DSPG2 antibody; PG 40 antibody; PG II antibody; PG S2 antibody; PG-S2 antibody; PG40 antibody; PGII antibody; PGS 2 antibody; PGS2 antibody; PGS2_HUMAN antibody; Proteoglycan core protein antibody; SLRR1B antibody; Small leucine rich protein 1B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
8,266 Da
OMIM
gene 610048
3D Structure
ModBase 3D Structure for P07585
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Decorin (343-359aa TFRCVYVRSAIQLGNYK), identical to the related mouse sequence, and different from the related rat sequence by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DCN antibody
Western Blot (WB)

Western Blot (WB) of anti-DCN antibody

Anti-Decorin antibody, MBS175601, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Kidney Tissue Lysate
Lane 3: SMMC Cell Lysate
Rabbit Anti-DCN Polyclonal Antibody – Cat# MBS175601

Western Blot (WB) of anti-DCN antibody

Anti-Decorin antibody, MBS175601, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: Rat Spleen Tissue Lysate
Lane 4: SMMC Cell Lysate
Lane 5: SMMC Cell Lysate
Rabbit Anti-DCN Polyclonal Antibody, Western Blot (WB) – Cat# MBS175601

Other Notes

Small volumes of anti-DCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCN purchase

MBS175601 is an antibody targeting DCN. Also known as Anti-Decorin antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.

NCBI GI #
129951
NCBI GeneID
1634
NCBI Accession #
P07585.1
UniProt Primary Accession #
P07585
UniProt Secondary Accession #
Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9
UniProt Related Accession #
P07585
NCBI Official Full Name
Decorin
NCBI Official Synonym Full Names
decorin
NCBI Official Symbol
DCN
NCBI Official Synonym Symbols
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
UniProt Protein Name
Decorin
UniProt Synonym Protein Names
Bone proteoglycan II; PG-S2; PG40
Protein Family
Decorin
UniProt Gene Name
DCN
UniProt Synonym Gene Names
SLRR1B
UniProt Entry Name
PGS2_HUMAN
NCBI Protein Information
decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II

NCBI Summary for DCN

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]
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UniProt Comments for DCN

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; wound healing; pathogenesis; response to lipopolysaccharide; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; chondroitin sulfate catabolic process; carbohydrate metabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development

Disease: Corneal Dystrophy, Congenital Stromal
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Research Articles on DCN

1. decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCN antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >83 publications with DCN and TGFB1
 VCAN antibody  >71 publications with DCN and VCAN
 EGFR antibody  >20 publications with DCN and EGFR
 THBS1 antibody  >6 publications with DCN and THBS1
 COL1A2 antibody  >6 publications with DCN and COL1A2
 DPT antibody  >4 publications with DCN and DPT
 FN1 antibody  >4 publications with DCN and FN1
 FBN1 antibody  >4 publications with DCN and FBN1
 ELN antibody  >1 publications with DCN and ELN

Pathways associated with anti-DCN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram

Diseases associated with anti-DCN antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >120 publications with DCN and Fibrosis
 Disease Models, Animal Antibodies  >97 publications with DCN and Disease Models, Animal
 Carcinoma Antibodies  >74 publications with DCN and Carcinoma
 Inflammation Antibodies  >56 publications with DCN and Inflammation
 Kidney Diseases Antibodies  >46 publications with DCN and Kidney Diseases
 Adenocarcinoma Antibodies  >27 publications with DCN and Adenocarcinoma
 Necrosis Antibodies  >24 publications with DCN and Necrosis
 Neoplasms, Experimental Antibodies  >24 publications with DCN and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >22 publications with DCN and Breast Neoplasms
 Liver Diseases Antibodies  >21 publications with DCN and Liver Diseases

Organs/Tissues associated with anti-DCN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >694 publications with DCN and Brain
 Nerve Antibodies  >297 publications with DCN and Nerve
 Connective Tissue Antibodies  >167 publications with DCN and Connective Tissue
 Skin Antibodies  >163 publications with DCN and Skin
 Bone Antibodies  >152 publications with DCN and Bone
 Muscle Antibodies  >152 publications with DCN and Muscle
 Vascular Antibodies  >131 publications with DCN and Vascular
 Ear Antibodies  >90 publications with DCN and Ear
 Kidney Antibodies  >82 publications with DCN and Kidney
 Lung Antibodies  >66 publications with DCN and Lung
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