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SFTPA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175703

Description: Rabbit IgG polyclonal antibody for Pulmonary surfactant-associated protein A1(SFTPA1) detection. Tested with WB in Human, Rat.Background: Surfactant protein A is an innate immune system collectin. The gene encoding SP-A map to mouse chromosome… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SFTPA1, Polyclonal Antibody
Full Product Name
Anti-SFTPA1 antibody
Product Gene Name
anti-SFTPA1 antibody
Product Synonym Names
Pulmonary surfactant-associated protein A1(PSP-A/PSPA/SP-A/SP-A1); surfactant protein A1; 35 kDa pulmonary surfactant associated protein antibody; 35 kDa pulmonary surfactant-associated protein antibody; Alveolar proteinosis protein antibody; COLEC4 antibody; Collectin 4 antibody; Collectin-4 antibody; FLJ50593 antibody; FLJ51913 antibody; FLJ61144 antibody; FLJ77898, antibody; FLJ79095 antibody; FLJ99559 antibody; MGC133365 antibody; MGC198590 antibody; OTTHUMP00000019928 antibody; OTTHUMP00000019929 antibody; OTTHUMP00000019930 antibody; OTTHUMP00000019931 antibody; PSAP antibody; PSP A antibody; PSP-A antibody; PSPA antibody; pulmonary surfactant associated protein A1 antibody; Pulmonary surfactant-associated protein A1 antibody; SFTA1_HUMAN antibody; SFTP1 antibody; SFTPA1 antibody; SFTPA1B antibody; SP A antibody; SP A1 antibody; SP-A antibody; SP-A1 antibody; SPA antibody; SPA1 antibody; surfactant protein A1 variant AB'D' 6A2 antibody; surfactant protein A1 variant AB'D' 6A3 antibody; surfactant protein A1 variant AB'D' 6A4 antibody; surfactant protein A1 variant ACD' 6A2 antibody; surfactant protein A1 variant ACD' 6A3 antibody; surfactant protein A1 variant ACD' 6A4 antibody; surfactant protein A1 variant AD' 6A antibody; surfactant protein A1 variant AD' 6A2 antibody; surfactant protein A1 variant AD' 6A3 antibody; surfactant protein A1 variant AD' 6A4 antibody; surfactant protein A1B antibody; surfactant, pulmonary associated protein A1A antibody; surfactant, pulmonary associated protein A1B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
Immunogen affinity purified.
Concentration
200ug/ml (lot specific)
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
27,736 Da
OMIM
gene 267450
3D Structure
ModBase 3D Structure for Q8IWL2
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SFTPA1 (221-236aa KEQCVEMYTDGQWNDR), different from the rat sequence by two amino acids.
Contents
Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SFTPA1 antibody
Western Blot (WB)

Western Blot (WB) of anti-SFTPA1 antibody

Anti-SFTPA1 antibody, MBS175703, Western blotting
Lane 1: Rat Lung Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: MK(55KD)
Rabbit Anti-SFTPA1 Polyclonal Antibody – Cat# MBS175703

Other Notes

Small volumes of anti-SFTPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFTPA1 purchase

MBS175703 is an antibody targeting SFTPA1. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SFTPA1. It may not necessarily be applicable to this product.

NCBI GI #
60416440
NCBI GeneID
653509
NCBI Accession #
Q8IWL2.2
UniProt Primary Accession #
Q8IWL2
UniProt Secondary Accession #
P07714; Q14DV4; Q5RIR5; Q5RIR7; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3
UniProt Related Accession #
Q8IWL2
NCBI Official Full Name
Pulmonary surfactant-associated protein A1
NCBI Official Synonym Full Names
surfactant protein A1
NCBI Official Symbol
SFTPA1
NCBI Official Synonym Symbols
SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
UniProt Protein Name
Pulmonary surfactant-associated protein A1
UniProt Synonym Protein Names
35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4
Protein Family
Pulmonary surfactant-associated protein
UniProt Gene Name
SFTPA1
UniProt Synonym Gene Names
COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B; PSP-A; PSPA; SP-A; SP-A1
UniProt Entry Name
SFTA1_HUMAN
NCBI Protein Information
pulmonary surfactant-associated protein A1; collectin-4; surfactant protein A1B; alveolar proteinosis protein; surfactant protein A1 variant AD' 6A; surfactant protein A1 variant ACD' 6A; surfactant protein A1 variant AD' 6A2; surfactant protein A1 variant AD' 6A3; surfactant protein A1 variant AD' 6A4; surfactant protein A1 variant AB'D' 6A; surfactant protein A1 variant ACD' 6A2; surfactant protein A1 variant ACD' 6A3; surfactant protein A1 variant ACD' 6A4; surfactant protein A1 variant AB'D' 6A2; surfactant protein A1 variant AB'D' 6A3; surfactant protein A1 variant AB'D' 6A4; surfactant, pulmonary-associated protein A1A; surfactant, pulmonary-associated protein A1B; 35 kDa pulmonary surfactant-associated protein

NCBI Summary for SFTPA1

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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UniProt Comments for SFTPA1

SFTPA1B: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB. Belongs to the SFTPA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region

Molecular Function: lipid transporter activity; carbohydrate binding

Biological Process: respiratory gaseous exchange; lipid transport

Disease: Pulmonary Fibrosis, Idiopathic
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Research Articles on SFTPA1

1. sequence variability at the 3'UTR of SFTPA1 and SFTPA2 gene variants differentially affects miRNA regulation of gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SFTPA1 antibody

 Products by Pathway  Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram

Diseases associated with anti-SFTPA1 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >36 publications with SFTPA1 and Lung Diseases
 Inflammation Antibodies  >15 publications with SFTPA1 and Inflammation
 Respiration Disorders Antibodies  >10 publications with SFTPA1 and Respiration Disorders
 Fibrosis Antibodies  >9 publications with SFTPA1 and Fibrosis
 Pulmonary Fibrosis Antibodies  >9 publications with SFTPA1 and Pulmonary Fibrosis
 Lung Neoplasms Antibodies  >8 publications with SFTPA1 and Lung Neoplasms
 Hypersensitivity Antibodies  >5 publications with SFTPA1 and Hypersensitivity
 Lung Injury Antibodies  >4 publications with SFTPA1 and Lung Injury
 Pneumonia Antibodies  >4 publications with SFTPA1 and Pneumonia
 Necrosis Antibodies  >4 publications with SFTPA1 and Necrosis

Organs/Tissues associated with anti-SFTPA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >78 publications with SFTPA1 and Lung
 Blood Antibodies  >10 publications with SFTPA1 and Blood
 Lymph Node Antibodies  >1 publications with SFTPA1 and Lymph Node
 Connective Tissue Antibodies  >1 publications with SFTPA1 and Connective Tissue
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