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N Cadherin (CDH2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175704

Description: Rabbit IgG polyclonal antibody for Cadherin-2(CDH2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: N-cadherin(NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver… More details

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Product Documentation
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
N Cadherin (CDH2), Polyclonal Antibody
Full Product Name
Anti-N Cadherin antibody
Product Gene Name
anti-CDH2 antibody
Product Synonym Names
Cadherin-2; cadherin 2, type 1, N-cadherin(neuronal); CADH2_HUMAN antibody; Cadherin 2 antibody; Cadherin 2 N cadherin neuronal antibody; Cadherin 2 type 1 antibody; Cadherin 2 type 1 N cadherin neuronal antibody; cadherin 2 type 1 N-cadherin neuronal antibody; Cadherin 2, type 1, N-cadherin(neuronal) antibody; Cadherin-2 antibody; Cadherin2 antibody; Calcium dependent adhesion protein neuronal antibody; CD325 antibody; CD325 antigen antibody; CDH2 antibody; CDHN antibody; CDw325 antibody; CDw325 antigen antibody; N cadherin 1 antibody; N-cadherin antibody; NCAD antibody; Neural Cadherin antibody; OTTHUMP00000066304 antibody; OTTHUMP00000067378 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
97,040 Da
OMIM
114020
3D Structure
ModBase 3D Structure for P19022
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human N Cadherin (701-714aa CQCDSNGDCTDVDR), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CDH2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-CDH2 antibody

Anti-N Cadherin antibody, MBS175704, Western blotting
Lane 1: MCF-7 Cell Lysate
Lane 2: HELA Cell Lysate
Rabbit Anti-CDH2 Polyclonal Antibody – Cat# MBS175704

Immunohistochemistry (IHC) of anti-CDH2 antibody

Anti-N Cadherin antibody, MBS175704, IHC(P)
IHC(P): Human Ovary Cancer Tissue
Rabbit Anti-CDH2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175704

Other Notes

Small volumes of anti-CDH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH2 purchase

MBS175704 is an antibody targeting CDH2. Also known as Anti-N Cadherin antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH2. It may not necessarily be applicable to this product.

NCBI GI #
116241277
NCBI GeneID
1000
NCBI Accession #
P19022.4
UniProt Primary Accession #
P19022
UniProt Secondary Accession #
Q14923; Q8N173; A8MWK3; B0YIY6
UniProt Related Accession #
P19022
NCBI Official Full Name
Cadherin-2
NCBI Official Synonym Full Names
cadherin 2, type 1, N-cadherin (neuronal)
NCBI Official Symbol
CDH2
NCBI Official Synonym Symbols
CDHN; NCAD; CD325; CDw325
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325
Protein Family
Cadherin
UniProt Gene Name
CDH2
UniProt Synonym Gene Names
CDHN; NCAD; N-cadherin
UniProt Entry Name
CADH2_HUMAN
NCBI Protein Information
cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal

NCBI Summary for CDH2

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDH2

CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: focal adhesion; cell-cell adherens junction; lamellipodium; apical plasma membrane; integral to membrane; plasma membrane; synapse; fascia adherens; intercellular junction; catenin complex

Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; alpha-catenin binding

Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; cell migration; muscle cell differentiation; glial cell differentiation; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; striated muscle cell differentiation; blood vessel morphogenesis; positive regulation of muscle cell differentiation; cell adhesion; homophilic cell adhesion
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Research Articles on CDH2

1. Studied the expression of E-cadherin, N-cadherin, TGF-beta1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDH2 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >70 publications with CDH2 and CTNNB1
 MMP9 antibody  >10 publications with CDH2 and MMP9
 JUP antibody  >4 publications with CDH2 and JUP
 CTNNA1 antibody  >2 publications with CDH2 and CTNNA1
 CTNND1 antibody  >2 publications with CDH2 and CTNND1
 SPAG9 antibody  >1 publications with CDH2 and SPAG9
 LRP5 antibody  >1 publications with CDH2 and LRP5
 FGFR1 antibody  >1 publications with CDH2 and FGFR1

Pathways associated with anti-CDH2 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram

Diseases associated with anti-CDH2 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >39 publications with CDH2 and Neoplasm Metastasis
 Disease Progression Antibodies  >30 publications with CDH2 and Disease Progression
 Breast Neoplasms Antibodies  >25 publications with CDH2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >22 publications with CDH2 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >19 publications with CDH2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >19 publications with CDH2 and Disease Models, Animal
 Heart Diseases Antibodies  >14 publications with CDH2 and Heart Diseases
 Prostatic Neoplasms Antibodies  >13 publications with CDH2 and Prostatic Neoplasms
 Liver Diseases Antibodies  >12 publications with CDH2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >12 publications with CDH2 and Neoplasms, Experimental

Organs/Tissues associated with anti-CDH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >52 publications with CDH2 and Muscle
 Brain Antibodies  >49 publications with CDH2 and Brain
 Embryonic Tissue Antibodies  >42 publications with CDH2 and Embryonic Tissue
 Heart Antibodies  >34 publications with CDH2 and Heart
 Vascular Antibodies  >31 publications with CDH2 and Vascular
 Lung Antibodies  >30 publications with CDH2 and Lung
 Bone Antibodies  >30 publications with CDH2 and Bone
 Eye Antibodies  >22 publications with CDH2 and Eye
 Liver Antibodies  >20 publications with CDH2 and Liver
 Prostate Antibodies  >16 publications with CDH2 and Prostate
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