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Aromatase (CYP19A1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175728

Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible… More details

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Product Overview

Online Datasheet in PDF
Product Name
Aromatase (CYP19A1), Polyclonal Antibody
Full Product Name
Anti-Aromatase antibody
Product Gene Name
anti-CYP19A1 antibody
Product Synonym Names
Cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO 1 antibody; ARO antibody; ARO1 antibody; Aromatase antibody; CP19A_HUMAN antibody; CPV antibody; CPV1 antibody; CYAR antibody; CYP19 antibody; CYP19A1 antibody; CYPXIX antibody; Cytochrome P-450AROM antibody; Cytochrome P450 19A1 antibody; Cytochrome P450 family 19 subfamily A polypeptide 1 antibody; Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody; Cytochrome P450, subfamily XIX(aromatization of androgens) antibody; Estrogen synthase antibody; Estrogen synthetase antibody; Flavoprotein linked monooxygenase antibody; MGC104309 antibody; Microsomal monooxygenase antibody; OTTHUMP00000162543 antibody; OTTHUMP00000198350 antibody; P 450AROM antibody; P450AROM antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
OMIM
613546
3D Structure
ModBase 3D Structure for P11511
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Aromatase (485-503aa KNMLEMIFTPRNSDRCLEH).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CYP19A1 antibody
Western Blot (WB)
Application Notes for anti-CYP19A1 antibody
WB: The detection limit for Aromatase is approximately 1ng/lane under non-reducing and reducing conditions.

Other applications have not been tested.
optimal dilutions should be determined by end user.

Western Blot (WB) of anti-CYP19A1 antibody

Anti-Aromatase antibody, MBS175728, Western blotting
Lane 1: Human Placenta Tissue Lysate
Lane 2: Human Placenta Tissue Lysate
Rabbit Anti-CYP19A1 Polyclonal Antibody – Cat# MBS175728

Immunohistochemistry (IHC) of anti-CYP19A1 antibody

Anti-Aromatase antibody, MBS175728, IHC(P)
IHC(P): Human Placenta Tissue
Rabbit Anti-CYP19A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175728

Other Notes

Small volumes of anti-CYP19A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP19A1 purchase

MBS175728 is an antibody targeting CYP19A1. Also known as Anti-Aromatase antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP19A1. It may not necessarily be applicable to this product.

NCBI GI #
117293
NCBI GeneID
1588
NCBI Accession #
P11511.3
UniProt Primary Accession #
P11511
UniProt Secondary Accession #
Q16731; Q3B764; Q58FA0; Q8IYJ7
UniProt Related Accession #
P11511
NCBI Official Full Name
Aromatase
NCBI Official Synonym Full Names
cytochrome P450, family 19, subfamily A, polypeptide 1
NCBI Official Symbol
CYP19A1
NCBI Official Synonym Symbols
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
UniProt Protein Name
Aromatase
UniProt Synonym Protein Names
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
Protein Family
Aromatase
UniProt Gene Name
CYP19A1
UniProt Synonym Gene Names
ARO1; CYAR; CYP19
UniProt Entry Name
CP19A_HUMAN
NCBI Protein Information
aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens)

NCBI Summary for CYP19A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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UniProt Comments for CYP19A1

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family.

Protein type: Lipid Metabolism - androgen and estrogen; EC 1.14.14.14; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum

Molecular Function: electron carrier activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxygen binding

Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; steroid biosynthetic process; estrogen biosynthetic process; sterol metabolic process

Disease: Aromatase Deficiency; Aromatase Excess Syndrome
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Research Articles on CYP19A1

1. the involvement of Compound 1 as a reactive intermediate in the final aromatization step of CYP19A1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYP19A1 antibody

 Reference Product  PubMed Publications
 HSD17B2 antibody  >312 publications with CYP19A1 and HSD17B2
 SRD5A2 antibody  >153 publications with CYP19A1 and SRD5A2
 FOXL2 antibody  >65 publications with CYP19A1 and FOXL2
 HSD17B1 antibody  >49 publications with CYP19A1 and HSD17B1
 HSD3B1 antibody  >42 publications with CYP19A1 and HSD3B1
 NR0B1 antibody  >20 publications with CYP19A1 and NR0B1
 HSD3B2 antibody  >15 publications with CYP19A1 and HSD3B2
 SRD5A1 antibody  >13 publications with CYP19A1 and SRD5A1
 HSD17B3 antibody  >13 publications with CYP19A1 and HSD17B3
 HSD17B6 antibody  >2 publications with CYP19A1 and HSD17B6

Pathways associated with anti-CYP19A1 antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Estrogen Biosynthesis Pathway antibodies  Estrogen Biosynthesis Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-CYP19A1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4116 publications with CYP19A1 and Breast Neoplasms
 Ovarian Diseases Antibodies  >460 publications with CYP19A1 and Ovarian Diseases
 Osteoporosis Antibodies  >431 publications with CYP19A1 and Osteoporosis
 Adenocarcinoma Antibodies  >392 publications with CYP19A1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >376 publications with CYP19A1 and Neoplasms, Experimental
 Infertility, Female Antibodies  >359 publications with CYP19A1 and Infertility, Female
 Pain Antibodies  >337 publications with CYP19A1 and Pain
 Endometriosis Antibodies  >318 publications with CYP19A1 and Endometriosis
 Hyperplasia Antibodies  >280 publications with CYP19A1 and Hyperplasia
 Nervous System Diseases Antibodies  >277 publications with CYP19A1 and Nervous System Diseases

Organs/Tissues associated with anti-CYP19A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2354 publications with CYP19A1 and Ovary
 Blood Antibodies  >2070 publications with CYP19A1 and Blood
 Brain Antibodies  >1672 publications with CYP19A1 and Brain
 Testis Antibodies  >984 publications with CYP19A1 and Testis
 Placenta Antibodies  >811 publications with CYP19A1 and Placenta
 Liver Antibodies  >495 publications with CYP19A1 and Liver
 Embryonic Tissue Antibodies  >316 publications with CYP19A1 and Embryonic Tissue
 Vascular Antibodies  >236 publications with CYP19A1 and Vascular
 Adrenal Gland Antibodies  >188 publications with CYP19A1 and Adrenal Gland
 Lung Antibodies  >155 publications with CYP19A1 and Lung
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