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Cardiac FABP (FABP3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175736

Description: Rabbit IgG polyclonal antibody for Fatty acid-binding protein, heart(FABP3) detection. Tested with WB, IHC-P, IHC-F in Human.Background: Heart-type fatty acid binding protein(hFABP) also known as mammary-derived growth inhibitor is a protein that… More details

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Product Overview

Online Datasheet in PDF
Product Name
Cardiac FABP (FABP3), Polyclonal Antibody
Full Product Name
Anti-Cardiac FABP antibody
Product Gene Name
anti-FABP3 antibody
Product Synonym Names
Fatty acid-binding protein, heart; fatty acid binding protein 3, muscle and heart(mammary-derived growth inhibitor); 422 protein antibody; Cardiac Fatty Acid Binding Protein antibody; FABP 11 antibody; FABP 3 antibody; FABP11 antibody; FABP3 antibody; FABPH_HUMAN antibody; Fatty acid binding protein 11 antibody; Fatty acid binding protein 3 antibody; Fatty acid binding protein 3 muscle and heart antibody; Fatty acid binding protein 3 muscle and heart mammary derived growth inhibitor antibody; Fatty acid binding protein 3 muscle antibody; Fatty acid binding protein 3, muscle and heart(mammary derived growth inhibitor) antibody; Fatty acid binding protein 3, muscle antibody; Fatty acid binding protein heart antibody; Fatty acid binding protein, heart antibody; Fatty acid binding protein, muscle and heart antibody; Fatty acid binding protein, skeletal muscle antibody; Fatty acid-binding protein 3 antibody; Fatty acid-binding protein antibody; H FABP antibody; H-FABP antibody; heart antibody; Heart type fatty acid binding protein antibody; Heart-type fatty acid-binding protein antibody; M FABP antibody; M-FABP antibody; Mammary derived growth inhibitor antibody; Mammary-derived growth inhibitor antibody; MDGI antibody; Muscle fatty acid binding protein antibody; Muscle fatty acid-binding protein antibody; Mylein protein P2 homolog antibody; O FABP antibody; OTTHUMP00000003898 antibody; P2 adopocyte protein antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
14,858 Da
OMIM
134651
3D Structure
ModBase 3D Structure for P05413
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cardiac FABP (119-133aa THGTAVCTRTYEKEA).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-FABP3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

Immunohistochemistry (IHC) of anti-FABP3 antibody

Cardiac FABP was detected in paraffin-embedded sections of rat cardiac muscle tissues using rabbit anti- Cardiac FABP Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Rabbit Anti-FABP3 Polyclonal Antibody – Cat# MBS175736

Immunohistochemistry (IHC) of anti-FABP3 antibody

Cardiac FABP was detected in paraffin-embedded sections of mouse skeletal muscletissues using rabbit anti- Cardiac FABP Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Rabbit Anti-FABP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175736

Immunohistochemistry (IHC) of anti-FABP3 antibody

Cardiac FABP was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- Cardiac FABP Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Rabbit Anti-FABP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175736

Western Blot (WB) of anti-FABP3 antibody

Figure 1. Western blot analysis of Cardiac FABP using anti-Cardiac FABP antibody (MBS175736).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: rat heart tissue lysate,
Lane 2: mouse heart tissue lysate.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Cardiac FABP antigen affinity purified polyclonal antibody at 0.5ug/mL overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for Cardiac FABP at approximately 15KD. The expected band size for Cardiac FABP is at 15KD.
Rabbit Anti-FABP3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS175736

Other Notes

Small volumes of anti-FABP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FABP3 purchase

MBS175736 is an antibody targeting FABP3. Also known as Anti-Cardiac FABP antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FABP3. It may not necessarily be applicable to this product.

NCBI GI #
119802
NCBI GeneID
2170
NCBI Accession #
P05413.4
UniProt Primary Accession #
P05413
UniProt Secondary Accession #
Q5VV93; Q99957; B2RAB6
UniProt Related Accession #
P05413
NCBI Official Full Name
Fatty acid-binding protein, heart
NCBI Official Synonym Full Names
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
NCBI Official Symbol
FABP3
NCBI Official Synonym Symbols
MDGI; FABP11; H-FABP; M-FABP; O-FABP
UniProt Protein Name
Fatty acid-binding protein, heart
UniProt Synonym Protein Names
Fatty acid-binding protein 3; Heart-type fatty acid-binding protein; H-FABP; Mammary-derived growth inhibitor; MDGI; Muscle fatty acid-binding protein; M-FABP
Protein Family
Fatty acid-binding protein
UniProt Gene Name
FABP3
UniProt Synonym Gene Names
FABP11; MDGI; H-FABP; MDGI; M-FABP
UniProt Entry Name
FABPH_HUMAN
NCBI Protein Information
fatty acid-binding protein, heart; fatty acid binding protein 11; mammary-derived growth inhibitor; muscle fatty acid-binding protein; Fatty acid-binding protein 3, muscle; heart-type fatty acid-binding protein

NCBI Summary for FABP3

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]
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UniProt Comments for FABP3

FABP3: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; cytosol; sarcoplasm

Molecular Function: protein binding; icosatetraenoic acid binding; cytoskeletal protein binding; long-chain fatty acid transporter activity

Biological Process: response to drug; negative regulation of cell proliferation; cholesterol homeostasis; regulation of fatty acid oxidation; fatty acid metabolic process; phospholipid homeostasis; response to insulin stimulus
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Research Articles on FABP3

1. Our findings indicate that Abeta-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FABP3 antibody

 Reference Product  PubMed Publications
 FABP1 antibody  >17 publications with FABP3 and FABP1
 FAAH antibody  >2 publications with FABP3 and FAAH
 SIRT1 antibody  >1 publications with FABP3 and SIRT1

Pathways associated with anti-FABP3 antibody

 Products by Pathway  Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-FABP3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >147 publications with FABP3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >127 publications with FABP3 and Heart Diseases
 Brain Diseases Antibodies  >37 publications with FABP3 and Brain Diseases
 Nervous System Diseases Antibodies  >34 publications with FABP3 and Nervous System Diseases
 Fatty Liver Antibodies  >31 publications with FABP3 and Fatty Liver
 Necrosis Antibodies  >26 publications with FABP3 and Necrosis
 Heart Failure Antibodies  >22 publications with FABP3 and Heart Failure
 Inflammation Antibodies  >18 publications with FABP3 and Inflammation
 Breast Neoplasms Antibodies  >15 publications with FABP3 and Breast Neoplasms
 Disease Models, Animal Antibodies  >14 publications with FABP3 and Disease Models, Animal

Organs/Tissues associated with anti-FABP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >221 publications with FABP3 and Heart
 Muscle Antibodies  >106 publications with FABP3 and Muscle
 Brain Antibodies  >79 publications with FABP3 and Brain
 Liver Antibodies  >32 publications with FABP3 and Liver
 Kidney Antibodies  >20 publications with FABP3 and Kidney
 Connective Tissue Antibodies  >19 publications with FABP3 and Connective Tissue
 Lung Antibodies  >12 publications with FABP3 and Lung
 Embryonic Tissue Antibodies  >11 publications with FABP3 and Embryonic Tissue
 Placenta Antibodies  >8 publications with FABP3 and Placenta
 Bone Antibodies  >5 publications with FABP3 and Bone
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