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5 Lipoxygenase (ALOX5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175757

Description: Rabbit IgG polyclonal antibody for Arachidonate 5-lipoxygenase(ALOX5) detection. Tested with WB, IHC-P in Human.Background: ALOX5(ARACHIDONATE 5-LIPOXYGENASE), also known as LOG5 or 5-LO(5-LIPOXYGENASE), is an enzyme that in humans is encoded by… More details

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Product Overview

Online Datasheet in PDF
Product Name
5 Lipoxygenase (ALOX5), Polyclonal Antibody
Full Product Name
Anti-5 Lipoxygenase antibody
Product Gene Name
anti-ALOX5 antibody
Product Synonym Names
Arachidonate 5-lipoxygenase(5-LO/5-lipoxygenase); arachidonate 5-lipoxygenase; 5 LO antibody; 5 LOX antibody; 5-lipoxygenase antibody; 5-LO antibody; 5-LOX antibody; 5LOX antibody; 5LPG antibody; ALOX 5 antibody; Alox5 antibody; Arachidonate 5 lipoxygenase antibody; Arachidonate 5-lipoxygenase antibody; arachidonic 5-lipoxygenase alpha-10 isoform antibody; arachidonic 5-lipoxygenase delta-10-13 isoform antibody; arachidonic 5-lipoxygenase delta-13 isoform antibody; arachidonic 5-lipoxygenase delta-p10 isoform antibody; Arachidonic acid 5 lipoxygenase antibody; Leukotriene A4 synthase antibody; LOG 5 antibody; LOG5 antibody; LOX5_HUMAN antibody; MGC163204 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
56,291 Da
OMIM
152390
3D Structure
ModBase 3D Structure for P09917
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human 5 Lipoxygenase (650-667aa AERNKKKQLPYYYLSPDR), different from the related rat and mouse sequences by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ALOX5 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-ALOX5 antibody

Anti-ALOX5 antibody, MBS175757, Western blotting
All lanes: Anti ALOX5 (MBS175757) at 0.5ug/ml
Lane 1: SW620 Whole Cell Lysate at 40ug
Lane 2: JURKAT Whole Cell Lysate at 40ug
Lane 3: COLO320 Whole Cell Lysate at 40ug
Lane 4: A549 Whole Cell Lysate at 40ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 78KD
Observed bind size: 78KD
Rabbit Anti-ALOX5 Polyclonal Antibody – Cat# MBS175757

Immunohistochemistry (IHC) of anti-ALOX5 antibody

Anti-ALOX5 antibody, MBS175757, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-ALOX5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175757

Other Notes

Small volumes of anti-ALOX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALOX5 purchase

MBS175757 is an antibody targeting ALOX5. Also known as Anti-5 Lipoxygenase antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOX5. It may not necessarily be applicable to this product.

NCBI GI #
126407
NCBI GeneID
240
NCBI Accession #
P09917.2
UniProt Primary Accession #
P09917
UniProt Secondary Accession #
Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8
UniProt Related Accession #
P09917
NCBI Official Full Name
Arachidonate 5-lipoxygenase
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Official Symbol
ALOX5
NCBI Official Synonym Symbols
5-LO; 5LPG; LOG5; 5-LOX
UniProt Protein Name
Arachidonate 5-lipoxygenase
Protein Family
Arachidonate 5-lipoxygenase
UniProt Gene Name
ALOX5
UniProt Synonym Gene Names
LOG5; 5-LO; 5-lipoxygenase
UniProt Entry Name
LOX5_HUMAN
NCBI Protein Information
arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform

NCBI Summary for ALOX5

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for ALOX5

5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.

Protein type: Lipid Metabolism - arachidonic acid; Nuclear envelope; EC 1.13.11.34; Oxidoreductase; Lipid Metabolism - linoleic acid

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol

Molecular Function: protein binding; iron ion binding; arachidonate 5-lipoxygenase activity

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Disease: Asthma, Susceptibility To
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Research Articles on ALOX5

1. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALOX5 antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >275 publications with ALOX5 and PTGS2
 ALOX5AP antibody  >204 publications with ALOX5 and ALOX5AP
 PTGS1 antibody  >109 publications with ALOX5 and PTGS1
 PLA2G4A antibody  >61 publications with ALOX5 and PLA2G4A
 LTA4H antibody  >30 publications with ALOX5 and LTA4H
 LTC4S antibody  >28 publications with ALOX5 and LTC4S
 COTL1 antibody  >10 publications with ALOX5 and COTL1
 MAPKAPK2 antibody  >8 publications with ALOX5 and MAPKAPK2

Pathways associated with anti-ALOX5 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram

Diseases associated with anti-ALOX5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >590 publications with ALOX5 and Inflammation
 Asthma Antibodies  >251 publications with ALOX5 and Asthma
 Lung Diseases Antibodies  >238 publications with ALOX5 and Lung Diseases
 Disease Models, Animal Antibodies  >174 publications with ALOX5 and Disease Models, Animal
 Atherosclerosis Antibodies  >123 publications with ALOX5 and Atherosclerosis
 Necrosis Antibodies  >117 publications with ALOX5 and Necrosis
 Edema Antibodies  >94 publications with ALOX5 and Edema
 Heart Diseases Antibodies  >59 publications with ALOX5 and Heart Diseases
 Neoplasms, Experimental Antibodies  >52 publications with ALOX5 and Neoplasms, Experimental
 Pain Antibodies  >49 publications with ALOX5 and Pain

Organs/Tissues associated with anti-ALOX5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1142 publications with ALOX5 and Blood
 Lung Antibodies  >259 publications with ALOX5 and Lung
 Brain Antibodies  >134 publications with ALOX5 and Brain
 Muscle Antibodies  >118 publications with ALOX5 and Muscle
 Bone Antibodies  >82 publications with ALOX5 and Bone
 Heart Antibodies  >73 publications with ALOX5 and Heart
 Kidney Antibodies  >66 publications with ALOX5 and Kidney
 Bone Marrow Antibodies  >60 publications with ALOX5 and Bone Marrow
 Intestine Antibodies  >51 publications with ALOX5 and Intestine
 Prostate Antibodies  >39 publications with ALOX5 and Prostate
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