Rabbit Anti-HSD17B6 Polyclonal Antibody – Cat# MBS175759

Anti- HSD17B6 antibody, MBS175759, Western blotting
All lanes: Anti HSD17B6 (MBS175759) at 0.5ug/ml
Lane 1: Human Placenta Tissue Lysate at 50ug
Lane 2: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 35KD
Observed bind size: 35KD

HSD17B6 Antibody – Rabbit Polyclonal

Name: HSD17B6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS175759
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175759

Description: Rabbit IgG polyclonal antibody for 17-beta-hydroxysteroid dehydrogenase type 6(HSD17B6) detection. Tested with WB, IHC-P in Human.Background: Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HSD17B6, Polyclonal Antibody

Full Product Name

Anti-HSD17B6 antibody

Product Gene Name

anti-HSD17B6 antibody

Product Synonym Names

17-beta-hydroxysteroid dehydrogenase type 6(17-beta-HSD 6/17-beta-HSD6); hydroxysteroid(17-beta) dehydrogenase 6 homolog(mouse); 17-beta-HSD 6 antibody; 17-beta-HSD6 antibody; 17-beta-hydroxysteroid dehydrogenase type 6 antibody; 3 hydroxysteroid epimerase antibody; 3(alpha>beta) hydroxysteroid epimerase antibody; 3(alpha>beta) hydroxysteroid epimerasel antibody; 3-alpha->beta-HSE antibody; 3-alpha->beta-hydroxysteroid epimerase antibody; H17B6_HUMAN antibody; HSD17B6 antibody; HSE antibody; Hydroxysteroid(17 beta) dehydrogenase 6 antibody; Hydroxysteroid(17 beta) dehydrogenase 6 homolog(mouse) antibody; Hydroxysteroid 17 beta dehydrogenase 6 antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3-alpha hydroxysteroid dehydrogenase antibody; Oxidoreductase antibody; Retinol dehydrogenase antibody; RODH antibody; SDR9C6 antibody; Short chain dehydrogenase/reductase family 9C, member 6 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

35,966 Da

OMIM

606623

3D Structure

ModBase 3D Structure for O14756

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6 (300-317aa SLADYILTRSWPKPAQAV).

Contents

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-HSD17B6 antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Other Notes

Small volumes of anti-HSD17B6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD17B6 purchase

MBS175759 is an antibody targeting HSD17B6. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B6. It may not necessarily be applicable to this product.

NCBI GI #

74739479

NCBI GeneID

8630

NCBI Accession #

O14756.1

UniProt Primary Accession #

O14756

UniProt Secondary Accession #

O43275

UniProt Related Accession #

O14756

NCBI Official Full Name

17-beta-hydroxysteroid dehydrogenase type 6

NCBI Official Synonym Full Names

hydroxysteroid (17-beta) dehydrogenase 6

NCBI Official Symbol

HSD17B6

NCBI Official Synonym Symbols

HSE; RODH; SDR9C6

UniProt Protein Name

17-beta-hydroxysteroid dehydrogenase type 6

UniProt Synonym Protein Names

3-alpha->beta-hydroxysteroid epimerase; 3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase

Protein Family

17-beta-hydroxysteroid dehydrogenase

UniProt Gene Name

HSD17B6

UniProt Synonym Gene Names

RODH; 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-HSE

UniProt Entry Name

H17B6_HUMAN

NCBI Protein Information

17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD 6; oxidoreductase; 3-alpha->beta-HSE; retinol dehydrogenase; 3-hydroxysteroid epimerase; 3-alpha->beta-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; short chain dehydrogenase/reductase family 9C, member 6; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase

NCBI Summary for HSD17B6

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

UniProt Comments for HSD17B6

HSD17B6: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Oxidoreductase; EC 1.1.1.239; EC 1.1.1.105; EC 1.1.1.62

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: endoplasmic reticulum; early endosome membrane; intracellular

Molecular Function: estradiol 17-beta-dehydrogenase activity; electron carrier activity; oxidoreductase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; retinol dehydrogenase activity

Biological Process: androgen biosynthetic process; androgen catabolic process

Research Articles on HSD17B6

1. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSD17B6 antibody

Reference Product	PubMed Publications
CYP19A1 antibody	>2 publications with HSD17B6 and CYP19A1
SRD5A2 antibody	>1 publications with HSD17B6 and SRD5A2
HSD3B2 antibody	>1 publications with HSD17B6 and HSD3B2
CYP1B1 antibody	>1 publications with HSD17B6 and CYP1B1

Pathways associated with anti-HSD17B6 antibody

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With Visual Transduction Pathway antibodies	Diseases Associated With Visual Transduction Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Retinol Metabolism Pathway antibodies	Retinol Metabolism Pathway Diagram
Retinol Metabolism Pathway antibodies	Retinol Metabolism Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Steroid Hormone Biosynthesis Pathway antibodies	Steroid Hormone Biosynthesis Pathway Diagram
Steroid Hormone Biosynthesis Pathway antibodies	Steroid Hormone Biosynthesis Pathway Diagram
The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies	The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
Visual Phototransduction Pathway antibodies	Visual Phototransduction Pathway Diagram

Diseases associated with anti-HSD17B6 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>1 publications with HSD17B6 and Mental Disorders
Cardiovascular Diseases Antibodies	>1 publications with HSD17B6 and Cardiovascular Diseases
Hyperplasia Antibodies	>1 publications with HSD17B6 and Hyperplasia

Organs/Tissues associated with anti-HSD17B6 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>6 publications with HSD17B6 and Prostate
Ovary Antibodies	>4 publications with HSD17B6 and Ovary
Uterus Antibodies	>2 publications with HSD17B6 and Uterus
Kidney Antibodies	>1 publications with HSD17B6 and Kidney
Embryonic Tissue Antibodies	>1 publications with HSD17B6 and Embryonic Tissue
Brain Antibodies	>1 publications with HSD17B6 and Brain
Liver Antibodies	>1 publications with HSD17B6 and Liver