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IL2RA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175766

Description: Rabbit IgG polyclonal antibody for Interleukin-2 receptor subunit alpha(IL2RA) detection. Tested with WB, IHC-P in Human.Background: IL2RA(Interleukin 2 receptor, alpha), also called IL2R, IL2R, Alpha Chain or CD25, is a protein that in humans is… More details

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Product Overview

Online Datasheet in PDF
Product Name
IL2RA, Polyclonal Antibody
Full Product Name
Anti-IL2RA antibody
Product Gene Name
anti-IL2RA antibody
Product Synonym Names
Interleukin-2 receptor subunit alpha(IL-2 receptor subunit alpha/IL-2-RA/IL-2R subunit alpha/IL2-RA); interleukin 2 receptor, alpha; CD25 antibody; IDDM10 antibody; IL 2 RA antibody; IL 2 receptor subunit alpha antibodyIL 2R alpha chain antibody; IL 2R subunit alpha antibody; IL-2 receptor subunit alpha antibody; IL-2-RA antibody; IL-2R subunit alpha antibody; IL2 RA antibody; IL2 Receptor alpha antibody; IL2 receptor subunit alpha antibody; IL2-RA antibody; IL2R alpha chain antibody; IL2R antibody; IL2R subunit alpha antibody; IL2RA antibody; IL2RA_HUMAN antibody; Interleukin 2 receptor alpha chain antibody; interleukin 2 receptor subunit alpha antibody; Interleukin 2 receptor, alpha antibody; Interleukin-2 receptor subunit alpha antibody; Ly 43 antibody; Ly43 antibody; OTTHUMP00000019030 antibody; OTTHUMP00000019031 antibody; OTTHUMP00000019032 antibody; p55 antibody; p55 chain antibody; T Cell Growth Factor Receptor antibody; TAC antigen antibody; TCGFR antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
30,819 Da
OMIM
606367
3D Structure
ModBase 3D Structure for P01589
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human IL2RA (39-57aa MAYKEGTMLNCECKRGFRR).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IL2RA antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-IL2RA antibody

Anti- CD25/IL-2sR Alpha antibody, MBS175766, Western blotting
All lanes: Anti CD25/IL-2sR Alpha (MBS175766) at 0.5ug/ml
Lane 1: SMMC Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Lane 3: JURKAT Whole Cell Lysate at 40ug
Lane 4: MCF-7 Whole Cell Lysate at 40ug
Lane 5: RAJI Whole Cell Lysate at 40ug
Lane 6: PANC Whole Cell Lysate at 40ug
Predicted bind size: 31KD
Observed bind size: 45KD
Rabbit Anti-IL2RA Polyclonal Antibody – Cat# MBS175766

Immunohistochemistry (IHC) of anti-IL2RA antibody

Anti- CD25/IL-2sR Alpha antibody, MBS175766, IHC(P)
IHC(P): Human Tonsil Tissue
Rabbit Anti-IL2RA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175766

Other Notes

Small volumes of anti-IL2RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL2RA purchase

MBS175766 is an antibody targeting IL2RA. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL2RA. It may not necessarily be applicable to this product.

NCBI GI #
124317
NCBI GeneID
3559
NCBI Accession #
P01589.1
UniProt Primary Accession #
P01589
UniProt Secondary Accession #
Q5W007
UniProt Related Accession #
P01589
NCBI Official Full Name
Interleukin-2 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 2 receptor, alpha
NCBI Official Symbol
IL2RA
NCBI Official Synonym Symbols
p55; CD25; IL2R; TCGFR; IDDM10
UniProt Protein Name
Interleukin-2 receptor subunit alpha
UniProt Synonym Protein Names
TAC antigen; p55; CD_antigen: CD25
Protein Family
Interleukin-2 receptor
UniProt Gene Name
IL2RA
UniProt Synonym Gene Names
IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA
UniProt Entry Name
IL2RA_HUMAN
NCBI Protein Information
interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha

NCBI Summary for IL2RA

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
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UniProt Comments for IL2RA

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding

Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis

Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10
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Research Articles on IL2RA

1. No association was found between IL2RA genotypes and the risk of erosion in the subgroup of anti-citrullinated protein antibody positive rheumatoid arthritis patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL2RA antibody

 Reference Product  PubMed Publications
 CD4 antibody  >2708 publications with IL2RA and CD4
 FOXP3 antibody  >1765 publications with IL2RA and FOXP3
 IL2RB antibody  >843 publications with IL2RA and IL2RB
 IL2RG antibody  >112 publications with IL2RA and IL2RG
 IL2 antibody  >111 publications with IL2RA and IL2
 PRF1 antibody  >47 publications with IL2RA and PRF1
 STAT3 antibody  >30 publications with IL2RA and STAT3
 JAK3 antibody  >24 publications with IL2RA and JAK3
 JAK1 antibody  >16 publications with IL2RA and JAK1
 LCK antibody  >9 publications with IL2RA and LCK

Pathways associated with anti-IL2RA antibody

 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-IL2RA antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >522 publications with IL2RA and Inflammation
 Necrosis Antibodies  >338 publications with IL2RA and Necrosis
 Lung Diseases Antibodies  >194 publications with IL2RA and Lung Diseases
 Liver Diseases Antibodies  >156 publications with IL2RA and Liver Diseases
 Diabetes Mellitus, Type 1 Antibodies  >146 publications with IL2RA and Diabetes Mellitus, Type 1
 Multiple Sclerosis Antibodies  >132 publications with IL2RA and Multiple Sclerosis
 Cardiovascular Diseases Antibodies  >126 publications with IL2RA and Cardiovascular Diseases
 Arthritis, Rheumatoid Antibodies  >114 publications with IL2RA and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >89 publications with IL2RA and Kidney Diseases
 HIV Infections Antibodies  >83 publications with IL2RA and HIV Infections

Organs/Tissues associated with anti-IL2RA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3646 publications with IL2RA and Blood
 Spleen Antibodies  >387 publications with IL2RA and Spleen
 Lymph Node Antibodies  >306 publications with IL2RA and Lymph Node
 Bone Antibodies  >248 publications with IL2RA and Bone
 Bone Marrow Antibodies  >232 publications with IL2RA and Bone Marrow
 Lung Antibodies  >212 publications with IL2RA and Lung
 Thymus Antibodies  >206 publications with IL2RA and Thymus
 Mixed Antibodies  >172 publications with IL2RA and Mixed
 Brain Antibodies  >105 publications with IL2RA and Brain
 Uterus Antibodies  >29 publications with IL2RA and Uterus
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