FOXP3 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Cell cycle regulation; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: protein complex; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; NF-kappaB binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; NFAT protein binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of interleukin-4 production; T cell activation; negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; positive regulation of transcription, DNA-dependent; myeloid cell homeostasis; negative regulation of cytokine secretion; negative regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; negative regulation of histone acetylation; negative regulation of interferon-gamma biosynthetic process; negative regulation of interleukin-2 production; positive regulation of interleukin-4 production; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; negative regulation of T cell proliferation; B cell homeostasis; regulation of transcription, DNA-dependent; negative regulation of interferon-gamma production; negative regulation of interleukin-6 production; T cell homeostasis; positive regulation of T cell anergy; regulation of isotype switching to IgG isotypes; tolerance induction to self antigen; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; T cell mediated immunity; negative regulation of transcription factor activity; response to virus; negative regulation of immune response; cytokine production; positive regulation of immature T cell proliferation in the thymus; negative regulation of T cell cytokine production; negative regulation of tumor necrosis factor production; positive regulation of peripheral T cell tolerance induction; chromatin remodeling; negative regulation of interleukin-17 production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-2 biosynthetic process; regulation of T cell anergy; negative regulation of interleukin-5 production; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inhibition of CREB transcription factor; negative regulation of cytokine biosynthetic process

Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked