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CXCR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176038

Description: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.Background: CXCR1(Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CXCR1, Polyclonal Antibody
Full Product Name
Anti-CXCR1 antibody
Product Gene Name
anti-CXCR1 antibody
Product Synonym Names
C-X-C chemokine receptor type 1; chemokine(C-X-C motif) receptor 1; C C antibody; C C CKR 1 antibody; C-X-C chemokine receptor type 1 antibody; CCCKR1 antibody; CD 181 antibody; CD128 antibody; CD181 antibody; CD181 antigen antibody; CDw128a antibody; Chemokine(C X C motif) receptor 1 antibody; Chemokine(C X C) receptor 1 antibody; Chemokine receptor 1 antibody; CKR 1 antibody; CMKAR1 antibody; CXC-R1 antibody; CXCR 1 antibody; CXCR-1 antibody; CXCR1 antibody; CXCR1_HUMAN antibody; High affinity interleukin 8 receptor A antibody; High affinity interleukin-8 receptor A antibody; IL 8 receptor type 1 antibody; IL 8R A antibody; IL-8 receptor type 1 antibody; IL-8R A antibody; IL8 receptor antibody; IL8 receptor type 1 antibody; IL8R1 antibody; IL8RA antibody; IL8RBA antibody; Interleukin 8 receptor alpha antibody; Interleukin 8 receptor type 1 antibody; Interleukin 8 receptor type A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
39,791 Da
OMIM
146929
3D Structure
ModBase 3D Structure for P25024
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1 (24-38aa DEDYSPCMLETETLN).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CXCR1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-CXCR1 antibody

Anti-CXCR1 antibody, MBS176038, Western blotting
All lanes: Anti CXCR1 (MBS176038) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: COLO320 Whole Cell Lysate at 40ug
Lane 3: M231 Whole Cell Lysate at 40ug
Lane 4: HT1080 Whole Cell Lysate at 40ug
Predicted bind size: 40KD
Observed bind size: 40KD
Rabbit Anti-CXCR1 Polyclonal Antibody – Cat# MBS176038

Immunohistochemistry (IHC) of anti-CXCR1 antibody

Anti-CXCR1 antibody, MBS176038, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-CXCR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176038

Other Notes

Small volumes of anti-CXCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR1 purchase

MBS176038 is an antibody targeting CXCR1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR1. It may not necessarily be applicable to this product.

NCBI GI #
108936015
NCBI GeneID
3577
NCBI Accession #
P25024.2
UniProt Primary Accession #
P25024
UniProt Secondary Accession #
Q2YEF8; Q2YEG4; Q2YEG5; Q2YEG7; Q2YEG8; Q53R18; Q6IN95; Q8N6T6; Q9P2T8; Q9P2T9; B2R6Q3
UniProt Related Accession #
P25024
NCBI Official Full Name
C-X-C chemokine receptor type 1
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 1
NCBI Official Symbol
CXCR1
NCBI Official Synonym Symbols
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
UniProt Protein Name
C-X-C chemokine receptor type 1
UniProt Synonym Protein Names
CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD_antigen: CD181
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCR1
UniProt Synonym Gene Names
CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A
UniProt Entry Name
CXCR1_HUMAN
NCBI Protein Information
C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A

NCBI Summary for CXCR1

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
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UniProt Comments for CXCR1

IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CXCR1

1. IL-8 induces autocrine signaling via an apical CXCR1 in intestinal epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CXCR1 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram

Diseases associated with anti-CXCR1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >226 publications with CXCR1 and Inflammation
 Lung Diseases Antibodies  >77 publications with CXCR1 and Lung Diseases
 Necrosis Antibodies  >70 publications with CXCR1 and Necrosis
 Skin Diseases Antibodies  >43 publications with CXCR1 and Skin Diseases
 Nervous System Diseases Antibodies  >34 publications with CXCR1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >21 publications with CXCR1 and Adenocarcinoma
 Liver Diseases Antibodies  >21 publications with CXCR1 and Liver Diseases
 Kidney Diseases Antibodies  >20 publications with CXCR1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >16 publications with CXCR1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >14 publications with CXCR1 and Heart Diseases

Organs/Tissues associated with anti-CXCR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >402 publications with CXCR1 and Blood
 Lung Antibodies  >91 publications with CXCR1 and Lung
 Bone Antibodies  >39 publications with CXCR1 and Bone
 Brain Antibodies  >35 publications with CXCR1 and Brain
 Liver Antibodies  >28 publications with CXCR1 and Liver
 Bone Marrow Antibodies  >27 publications with CXCR1 and Bone Marrow
 Intestine Antibodies  >18 publications with CXCR1 and Intestine
 Heart Antibodies  >15 publications with CXCR1 and Heart
 Spleen Antibodies  >13 publications with CXCR1 and Spleen
 Thymus Antibodies  >7 publications with CXCR1 and Thymus
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