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Bone Sialoprotein (IBSP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176061

Description: Rabbit IgG polyclonal antibody for Bone sialoprotein 2(IBSP) detection. Tested with WB, IHC-P in Mouse, Rat.Background: IBSP(integrin-binding sialoprotein) is also known as BSP. The protein encoded by this gene is a major structural protein of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bone Sialoprotein (IBSP), Polyclonal Antibody
Full Product Name
Anti-Bone Sialoprotein antibody
Product Gene Name
anti-IBSP antibody
Product Synonym Names
Bone sialoprotein 2; integrin-binding sialoprotein; BNSP antibody; Bone sialoprotein 2 antibody; Bone sialoprotein II antibody; BSP antibody; BSP II antibody; BSPII antibody; Cell binding sialoprotein antibody; Cell-binding sialoprotein antibody; IBSP antibody; Integrin binding sialoprotein antibody; Integrin-binding sialoprotein antibody; SIAL_HUMAN antibody; SPII antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized; Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for Q61711
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Bone Sialoprotein, different from the related rat sequence by one amino acid
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IBSP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IBSP antibody
Western blot
Concentration: 0.1-0.5ug/ml
Species: Mouse, Rat

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Species: Mouse, Rat

Immunohistochemistry (IHC) of anti-IBSP antibody

Anti-Bone Sialoprotein antibody, MBS176061, IHC(P)
IHC(P): Rat Liver Tissue
Rabbit Anti-IBSP Polyclonal Antibody – Cat# MBS176061

Western Blot (WB) of anti-IBSP antibody

Anti-Bone Sialoprotein antibody, MBS176061, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: Rat Kidney Tissue Lysate
Rabbit Anti-IBSP Polyclonal Antibody, Western Blot (WB) – Cat# MBS176061

Immunohistochemistry (IHC) of anti-IBSP antibody

IHC analysis of IBSP using anti-IBSP antibody. IBSP was detected in paraffin-embedded section of mouse pancreas tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-IBSP Antibody (PA1887) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen
Rabbit Anti-IBSP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176061

Other Notes

Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IBSP purchase

MBS176061 is an antibody targeting IBSP. Also known as Anti-Bone Sialoprotein antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.

NCBI GI #
341942035
NCBI GeneID
15891
NCBI Accession #
Q61711.2
UniProt Primary Accession #
Q61711
UniProt Secondary Accession #
Q61363; Q80VR6
UniProt Related Accession #
Q61711
NCBI Official Full Name
Bone sialoprotein 2
NCBI Official Synonym Full Names
integrin binding sialoprotein
NCBI Official Symbol
Ibsp
NCBI Official Synonym Symbols
BSP; Bsp2; BSPII; BSP II
UniProt Protein Name
Bone sialoprotein 2
UniProt Synonym Protein Names
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
Protein Family
Bone sialoprotein
UniProt Gene Name
Ibsp
UniProt Synonym Gene Names
BSP II
UniProt Entry Name
SIAL_MOUSE
NCBI Protein Information
bone sialoprotein 2; bone sialoprotein II; cell-binding sialoprotein; integrin-binding sialoprotein

UniProt Comments for IBSP

Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane; extracellular region

Biological Process: osteoblast differentiation; ossification; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion
Show more

Research Articles on IBSP

1. BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IBSP antibody

 Reference Product  PubMed Publications
 Itga2b antibody  >1 publications with IBSP and Itga2b
 Itgb3 antibody  >1 publications with IBSP and Itgb3
 Itgav antibody  >1 publications with IBSP and Itgav

Pathways associated with anti-IBSP antibody

 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-IBSP antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >42 publications with IBSP and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >24 publications with IBSP and Neoplasm Metastasis
 Kidney Diseases Antibodies  >14 publications with IBSP and Kidney Diseases
 Neoplasms, Experimental Antibodies  >12 publications with IBSP and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >11 publications with IBSP and Prostatic Neoplasms
 Inflammation Antibodies  >9 publications with IBSP and Inflammation
 Lung Diseases Antibodies  >9 publications with IBSP and Lung Diseases
 Necrosis Antibodies  >6 publications with IBSP and Necrosis
 Neoplasm Invasiveness Antibodies  >6 publications with IBSP and Neoplasm Invasiveness
 Nervous System Diseases Antibodies  >6 publications with IBSP and Nervous System Diseases

Organs/Tissues associated with anti-IBSP antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >667 publications with IBSP and Bone
 Molar Antibodies  >39 publications with IBSP and Molar
 Embryonic Tissue Antibodies  >38 publications with IBSP and Embryonic Tissue
 Joint Antibodies  >25 publications with IBSP and Joint
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