Rabbit Anti-TBX21 Polyclonal Antibody – Cat# MBS176063

Anti-T-bet/Tbx21 antibody, MBS176063, Western blotting
Recombinant Protein Detection Source: E.coli derived -recombinant Human TBX21,34.7KD(162aa tag+ V381-N535)
Lane 1: Recombinant Human TBX21 Protein 5ng
Lane 2: Recombinant Human TBX21 Protein 2.5ng
Lane 3: Recombinant Human TBX21 Protein 1.25ng

T-Bet/Tbx21 (TBX21) Antibody – Rabbit Polyclonal

Name: TBX21 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS176063
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176063

Description: Rabbit IgG polyclonal antibody for T-box transcription factor TBX21(TBX21) detection. Tested with WB in Human, Mouse, Rat.Background: TBX21(T-Box 21), also called TBET, is a protein that in humans is encoded by the TBX21 gene. This gene is a… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

T-bet/Tbx21, Polyclonal Antibody

Full Product Name

Anti-T-bet/Tbx21 antibody

Product Gene Name

anti-TBX21 antibody

Product Synonym Names

T-box transcription factor TBX21; T-box 21; T bet antibody; T box 21 antibody; T box expressed in T cells antibody; T box protein 21 antibody; T box transcription factor TBX21 antibody; T cell specific T box transcription factor antibody; T cell specific T box transcription factor T bet antibody; T PET antibody; T-box protein 21 antibody; T-box transcription factor TBX21 antibody; T-cell-specific T-box transcription factor T-bet antibody; TBET antibody; TBLYM antibody; TBX 21 antibody; TBX21 antibody; TBX21_HUMAN antibody; TPET antibody; Transcription factor TBLYM antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

58,328 Da

OMIM

604895

3D Structure

ModBase 3D Structure for Q9UL17

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human T-bet (522-535aa DKEAEGQFYNYFPN), different from the related rat and mouse sequences by one amino acid.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-TBX21 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-TBX21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBX21 purchase

MBS176063 is an antibody targeting TBX21. Also known as Anti-T-bet/Tbx21 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBX21. It may not necessarily be applicable to this product.

NCBI GI #

12230772

NCBI GeneID

30009

NCBI Accession #

Q9UL17.1

UniProt Primary Accession #

Q9UL17

UniProt Related Accession #

Q9UL17

NCBI Official Full Name

T-box transcription factor TBX21

NCBI Official Synonym Full Names

T-box 21

NCBI Official Symbol

TBX21

NCBI Official Synonym Symbols

TBET; T-PET; T-bet; TBLYM

UniProt Protein Name

T-box transcription factor TBX21

UniProt Synonym Protein Names

T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM

Protein Family

T-box transcription factor

UniProt Gene Name

TBX21

UniProt Synonym Gene Names

TBET; TBLYM; T-box protein 21

UniProt Entry Name

TBX21_HUMAN

NCBI Protein Information

T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet

NCBI Summary for TBX21

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

UniProt Comments for TBX21

TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function: transcription factor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to virus; multicellular organismal development; positive regulation of transcription, DNA-dependent; T cell differentiation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance

Research Articles on TBX21

1. IRTA1 and T-bet are positive markers for the diagnosis of nodal marginal zone lymphoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBX21 antibody

Reference Product	PubMed Publications
GATA3 antibody	>288 publications with TBX21 and GATA3
STAT1 antibody	>72 publications with TBX21 and STAT1
IFNG antibody	>51 publications with TBX21 and IFNG
CXCR3 antibody	>31 publications with TBX21 and CXCR3
IL12RB2 antibody	>10 publications with TBX21 and IL12RB2
JAK2 antibody	>5 publications with TBX21 and JAK2
IL12B antibody	>3 publications with TBX21 and IL12B
TYK2 antibody	>1 publications with TBX21 and TYK2

Pathways associated with anti-TBX21 antibody

Products by Pathway	Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram
IL27-mediated Signaling Events Pathway antibodies	IL27-mediated Signaling Events Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with anti-TBX21 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>192 publications with TBX21 and Inflammation
Disease Models, Animal Antibodies	>118 publications with TBX21 and Disease Models, Animal
Lung Diseases Antibodies	>112 publications with TBX21 and Lung Diseases
Asthma Antibodies	>103 publications with TBX21 and Asthma
Respiratory Hypersensitivity Antibodies	>88 publications with TBX21 and Respiratory Hypersensitivity
Necrosis Antibodies	>51 publications with TBX21 and Necrosis
Liver Diseases Antibodies	>26 publications with TBX21 and Liver Diseases
Kidney Diseases Antibodies	>20 publications with TBX21 and Kidney Diseases
Lupus Erythematosus, Systemic Antibodies	>18 publications with TBX21 and Lupus Erythematosus, Systemic
Hepatitis Antibodies	>18 publications with TBX21 and Hepatitis

Organs/Tissues associated with anti-TBX21 antibody

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>98 publications with TBX21 and Spleen
Lymph Node Antibodies	>45 publications with TBX21 and Lymph Node
Pancreas Antibodies	>4 publications with TBX21 and Pancreas