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PGK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176104

Description: Rabbit IgG polyclonal antibody for Phosphoglycerate kinase 1(PGK1) detection. Tested with WB in Human, Mouse, Rat.Background: PGK1(Phosphoglycerate Kinase 1), also known as PGKA, is an enzyme that in humans is encoded by the PGK1 gene. Willard et… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGK1, Polyclonal Antibody
Full Product Name
Anti-PGK1 antibody
Product Gene Name
anti-PGK1 antibody
Product Synonym Names
Phosphoglycerate kinase 1; phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein antibody; MGC117307 antibody; MGC8947 antibody; MIG10 antibody; pgk1 antibody; PGK1_HUMAN antibody; PGKA antibody; Phosphoglycerate kinase 1 antibody; Primer recognition protein 2 antibody; PRP 2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
41,429 Da
OMIM
311800
3D Structure
ModBase 3D Structure for P00558
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human PGK1 (166-180aa FGTAHRAHSSMVGVN), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PGK1 antibody
Western Blot (WB)

Western Blot (WB) of anti-PGK1 antibody

Anti-PGK1 antibody, MBS176104, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: Rat Lung Tissue Lysate
Lane 4: A431 Cell Lysate
Lane 5: COLO320 Cell Lysate
Lane 6: HELA Cell Lysate
Lane 7: A549 Cell Lysate
Lane 8: JURKAT Cell Lysate
Rabbit Anti-PGK1 Polyclonal Antibody – Cat# MBS176104

Immunohistochemistry (IHC) of anti-PGK1 antibody

Anti-PGK1 antibody, MBS176104, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-PGK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176104

Other Notes

Small volumes of anti-PGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGK1 purchase

MBS176104 is an antibody targeting PGK1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PGK1. It may not necessarily be applicable to this product.

NCBI GI #
52788229
NCBI GeneID
5230
NCBI Accession #
P00558.3
UniProt Primary Accession #
P00558
UniProt Secondary Accession #
Q5J7W1; Q6IBT6; Q8NI87; A8K4W6; B7Z7A9
UniProt Related Accession #
P00558
NCBI Official Full Name
Phosphoglycerate kinase 1
NCBI Official Synonym Full Names
phosphoglycerate kinase 1
NCBI Official Symbol
PGK1
NCBI Official Synonym Symbols
PGKA; MIG10; HEL-S-68p
UniProt Protein Name
Phosphoglycerate kinase 1
UniProt Synonym Protein Names
Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2
Protein Family
Phosphoglycerate kinase
UniProt Gene Name
PGK1
UniProt Synonym Gene Names
PGKA; PRP 2
UniProt Entry Name
PGK1_HUMAN
NCBI Protein Information
phosphoglycerate kinase 1; PRP 2; primer recognition protein 2; cell migration-inducing gene 10 protein; epididymis secretory sperm binding protein Li 68p

NCBI Summary for PGK1

The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
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UniProt Comments for PGK1

PGK1: an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein).

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; EC 2.7.2.3

Chromosomal Location of Human Ortholog: Xq13.3

Cellular Component: membrane; cytosol

Molecular Function: protein binding; phosphoglycerate kinase activity; ATP binding

Biological Process: glycolysis; epithelial cell differentiation; carbohydrate metabolic process; glucose metabolic process; pathogenesis; phosphorylation; gluconeogenesis

Disease: Phosphoglycerate Kinase 1 Deficiency
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Research Articles on PGK1

1. PGK1 could promote radioresistance in U251 human cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PGK1 antibody

 Reference Product  PubMed Publications
 GAPDH antibody  >44 publications with PGK1 and GAPDH
 HIF1A antibody  >21 publications with PGK1 and HIF1A
 ENO1 antibody  >13 publications with PGK1 and ENO1
 TPI1 antibody  >9 publications with PGK1 and TPI1
 BPGM antibody  >2 publications with PGK1 and BPGM
 GAPDHS antibody  >1 publications with PGK1 and GAPDHS
 PGAM2 antibody  >1 publications with PGK1 and PGAM2

Pathways associated with anti-PGK1 antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram

Diseases associated with anti-PGK1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >35 publications with PGK1 and Nervous System Diseases
 Anemia Antibodies  >17 publications with PGK1 and Anemia
 Liver Diseases Antibodies  >10 publications with PGK1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >10 publications with PGK1 and Neoplasms, Experimental
 Inflammation Antibodies  >10 publications with PGK1 and Inflammation
 Liver Neoplasms Antibodies  >9 publications with PGK1 and Liver Neoplasms
 Immune System Diseases Antibodies  >8 publications with PGK1 and Immune System Diseases
 Neoplasm Metastasis Antibodies  >7 publications with PGK1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >7 publications with PGK1 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >6 publications with PGK1 and Cardiovascular Diseases

Organs/Tissues associated with anti-PGK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with PGK1 and Blood
 Brain Antibodies  >29 publications with PGK1 and Brain
 Liver Antibodies  >24 publications with PGK1 and Liver
 Muscle Antibodies  >17 publications with PGK1 and Muscle
 Vascular Antibodies  >15 publications with PGK1 and Vascular
 Lung Antibodies  >14 publications with PGK1 and Lung
 Bone Antibodies  >14 publications with PGK1 and Bone
 Skin Antibodies  >13 publications with PGK1 and Skin
 Kidney Antibodies  >10 publications with PGK1 and Kidney
 Prostate Antibodies  >10 publications with PGK1 and Prostate
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