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MYBL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176151

Description: Rabbit IgG polyclonal antibody for Myb-related protein B(MYBL2) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.Background: MYBL2(V-MYB avian myeloblastosis viral oncogene homolog-like 2), also called MYB-RELATED GENE BMYB, is a… More details

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Product Overview

Online Datasheet in PDF
Product Name
B MyB (MYBL2), Polyclonal Antibody
Full Product Name
Anti-B MyB antibody
Product Gene Name
anti-MYBL2 antibody
Product Synonym Names
Myb-related protein B; v-myb myeloblastosis viral oncogene homolog(avian)-like 2; B-Myb antibody; BMyB antibody; MGC15600 antibody; MYB L2 antibody; Myb related protein B antibody; Myb-like protein 2 antibody; Myb-related protein B antibody; MybB antibody; MYBB_HUMAN antibody; MYBL 2 antibody; MYBL2 antibody; v myb avian myeloblastosis viral oncogene homolog like 2 antibody; v myb myeloblastosis viral oncogene homolog(avian) like 2 antibody; v myb myeloblastosis viral oncogene homolog like 2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
75,865 Da
OMIM
601415
3D Structure
ModBase 3D Structure for P10244
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human B MyB (1-17aa MSRRTRCEDLDELHYQD), identical to the related mouse sequence and different from the related rat sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-MYBL2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Western Blot (WB) of anti-MYBL2 antibody

Anti-B MyB antibody, MBS176151, Western blotting
Recombinant Protein Detection Source: E.coli derived -recombinant Human MYBL2, 46.8KD(162aa tag+ M1-L245)
Lane 1: Recombinant Human MYBL2 Protein 10ng
Lane 2: Recombinant Human MYBL2 Protein 5ng
Lane 3: Recombinant Human MYBL2 Protein 2.5ng
Rabbit Anti-MYBL2 Polyclonal Antibody – Cat# MBS176151

Immunohistochemistry (IHC) of anti-MYBL2 antibody

Anti-B MyB antibody, MBS176151, IHC(P)
IHC(P): Rat Brain Tissue
Rabbit Anti-MYBL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176151

Western Blot (WB) of anti-MYBL2 antibody

Anti-B MyB antibody, MBS176151, Western blotting
Lane 1: Rat Spleen Tissue Lysate
Lane 2: Rat Thymus Tissue Lysate
Lane 3: Rat Brain Tissue Lysate
Lane 4: HELA Cell Lysate
Lane 5: COLO320 Cell Lysate
Lane 6: MCF-7 Cell Lysate
Rabbit Anti-MYBL2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS176151

Immunocytochemistry (ICC) of anti-MYBL2 antibody

Anti-B MyB antibody, MBS176151, ICC
ICC: A549 Cell
Rabbit Anti-MYBL2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS176151

Immunohistochemistry (IHC) of anti-MYBL2 antibody

Anti-B MyB antibody, MBS176151, IHC(P)
IHC(P): Human Tonsil Tissue
Rabbit Anti-MYBL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176151

Other Notes

Small volumes of anti-MYBL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYBL2 purchase

MBS176151 is an antibody targeting MYBL2. Also known as Anti-B MyB antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MYBL2. It may not necessarily be applicable to this product.

NCBI GI #
127584
NCBI GeneID
4605
NCBI Accession #
P10244.1
UniProt Primary Accession #
P10244
UniProt Secondary Accession #
Q53F07; B2RBS5; B7Z8D9; F8W6N6
UniProt Related Accession #
P10244
NCBI Official Full Name
Myb-related protein B
NCBI Official Synonym Full Names
v-myb avian myeloblastosis viral oncogene homolog-like 2
NCBI Official Symbol
MYBL2
NCBI Official Synonym Symbols
BMYB; B-MYB
UniProt Protein Name
Myb-related protein B
UniProt Synonym Protein Names
Myb-like protein 2
Protein Family
Myb-related protein
UniProt Gene Name
MYBL2
UniProt Synonym Gene Names
BMYB; B-Myb
UniProt Entry Name
MYBB_HUMAN
NCBI Protein Information
myb-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2

NCBI Summary for MYBL2

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
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UniProt Comments for MYBL2

B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

Protein type: Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm

Molecular Function: protein binding; chromatin binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle
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Research Articles on MYBL2

1. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYBL2 antibody

 Reference Product  PubMed Publications
 E2F1 antibody  >17 publications with MYBL2 and E2F1
 CCND1 antibody  >14 publications with MYBL2 and CCND1
 RBL1 antibody  >12 publications with MYBL2 and RBL1
 E2F4 antibody  >11 publications with MYBL2 and E2F4
 CCNA2 antibody  >8 publications with MYBL2 and CCNA2
 LIN9 antibody  >8 publications with MYBL2 and LIN9
 TFDP1 antibody  >3 publications with MYBL2 and TFDP1
 CDK1 antibody  >3 publications with MYBL2 and CDK1
 CREBBP antibody  >1 publications with MYBL2 and CREBBP

Pathways associated with anti-MYBL2 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G0 And Early G1 Pathway antibodies  G0 And Early G1 Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Mitotic G1-G1/S Phases Pathway antibodies  Mitotic G1-G1/S Phases Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram

Diseases associated with anti-MYBL2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >20 publications with MYBL2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >16 publications with MYBL2 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >8 publications with MYBL2 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >6 publications with MYBL2 and Neoplasms, Experimental
 Uterine Neoplasms Antibodies  >6 publications with MYBL2 and Uterine Neoplasms
 Liver Diseases Antibodies  >5 publications with MYBL2 and Liver Diseases
 Prostatic Neoplasms Antibodies  >5 publications with MYBL2 and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >5 publications with MYBL2 and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >4 publications with MYBL2 and Uterine Cervical Neoplasms
 Fibrosis Antibodies  >3 publications with MYBL2 and Fibrosis

Organs/Tissues associated with anti-MYBL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with MYBL2 and Blood
 Liver Antibodies  >11 publications with MYBL2 and Liver
 Muscle Antibodies  >11 publications with MYBL2 and Muscle
 Bone Antibodies  >10 publications with MYBL2 and Bone
 Vascular Antibodies  >9 publications with MYBL2 and Vascular
 Lung Antibodies  >7 publications with MYBL2 and Lung
 Prostate Antibodies  >7 publications with MYBL2 and Prostate
 Bone Marrow Antibodies  >6 publications with MYBL2 and Bone Marrow
 Testis Antibodies  >6 publications with MYBL2 and Testis
 Brain Antibodies  >5 publications with MYBL2 and Brain
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