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LAT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176153

Description: Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 2(LAT2) detection. Tested with WB in Human.Background: LAT2(Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL, is a protein that in… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NTAL (LAT2), Polyclonal Antibody
Full Product Name
Anti-NTAL antibody
Product Gene Name
anti-LAT2 antibody
Product Synonym Names
Linker for activation of T-cells family member 2; linker for activation of T cells family, member 2; HSPC046 antibody; LAB antibody; Lat2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Linker of Activated B cells antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T Cell Activation Linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren Syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
12,255 Da
OMIM
605719
3D Structure
ModBase 3D Structure for Q9GZY6
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human NTAL (34-48aa KRSEKIYQQRSLRED).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-LAT2 antibody
Western Blot (WB)

Western Blot (WB) of anti-LAT2 antibody

Anti-NTAL antibody, MBS176153, Western blotting
Recombinant Protein Detection Source: E.coli derived -recombinant Human LAT2, 37.8KD(162aa tag+ M1-A182)
Lane 1: Recombinant Human LAT2 Protein 10ng
Lane 2: Recombinant Human LAT2 Protein 5ng
Lane 3: Recombinant Human LAT2 Protein 2.5ng
Lane 4: Recombinant Human LAT2 Protein 1.25ng
Rabbit Anti-LAT2 Polyclonal Antibody – Cat# MBS176153

Other Notes

Small volumes of anti-LAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAT2 purchase

MBS176153 is an antibody targeting LAT2. Also known as Anti-NTAL antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LAT2. It may not necessarily be applicable to this product.

NCBI GI #
74752543
NCBI GeneID
7462
NCBI Accession #
Q9GZY6.1
UniProt Primary Accession #
Q9GZY6
UniProt Secondary Accession #
Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9
UniProt Related Accession #
Q9GZY6
NCBI Official Full Name
Linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family, member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
Protein Family
Linker for activation of T-cells family
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Protein Information
linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2

NCBI Summary for LAT2

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for LAT2

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
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Research Articles on LAT2

1. The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LAT2 antibody

 Reference Product  PubMed Publications
 LAT antibody  >48 publications with LAT2 and LAT
 GRB2 antibody  >13 publications with LAT2 and GRB2
 CBL antibody  >4 publications with LAT2 and CBL
 GAB1 antibody  >2 publications with LAT2 and GAB1
 BLNK antibody  >1 publications with LAT2 and BLNK
 SOS1 antibody  >1 publications with LAT2 and SOS1

Pathways associated with anti-LAT2 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway antibodies  Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway Diagram

Diseases associated with anti-LAT2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with LAT2 and Inflammation
 Disease Models, Animal Antibodies  >7 publications with LAT2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >7 publications with LAT2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >7 publications with LAT2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with LAT2 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with LAT2 and Kidney Diseases
 Necrosis Antibodies  >5 publications with LAT2 and Necrosis
 Brain Diseases Antibodies  >4 publications with LAT2 and Brain Diseases
 Death Antibodies  >3 publications with LAT2 and Death
 Liver Neoplasms Antibodies  >3 publications with LAT2 and Liver Neoplasms

Organs/Tissues associated with anti-LAT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >57 publications with LAT2 and Blood
 Brain Antibodies  >44 publications with LAT2 and Brain
 Kidney Antibodies  >32 publications with LAT2 and Kidney
 Intestine Antibodies  >28 publications with LAT2 and Intestine
 Muscle Antibodies  >14 publications with LAT2 and Muscle
 Placenta Antibodies  >13 publications with LAT2 and Placenta
 Liver Antibodies  >11 publications with LAT2 and Liver
 Eye Antibodies  >9 publications with LAT2 and Eye
 Spleen Antibodies  >5 publications with LAT2 and Spleen
 Lung Antibodies  >5 publications with LAT2 and Lung
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