SMAD1 Antibody – Rabbit Polyclonal

SMAD1: transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated.

Protein type: Transcription factor; DNA-binding

Cellular Component: transcription factor complex; protein complex; cytoplasm; nuclear inner membrane; intracellular; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; metal ion binding; transcription factor activity; protein kinase binding

Biological Process: response to drug; transcription from RNA polymerase II promoter; transcription, DNA-dependent; MAPKKK cascade; cardiac muscle cell proliferation; protein amino acid phosphorylation; SMAD protein complex assembly; mesodermal cell fate commitment; BMP signaling pathway; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; homeostatic process; cartilage development; transforming growth factor beta receptor signaling pathway; gamete generation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; osteoblast fate commitment; hindbrain development