FER Antibody – Rabbit Polyclonal

Fer: a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth.

Protein type: EC 2.7.10.2; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Fer family

Chromosomal Location of Human Ortholog: 5q21

Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; nuclear chromatin; cytoplasm; cell cortex; cytosol; cell junction; nucleus; actin cytoskeleton

Molecular Function: protein binding; cadherin binding; gamma-catenin binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; actin binding; protein kinase binding; protein phosphatase 1 binding; lipid binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding

Biological Process: regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; diapedesis; tyrosine phosphorylation of Stat3 protein; negative regulation of mast cell activation during immune response; platelet-derived growth factor receptor signaling pathway; response to lipopolysaccharide; microtubule cytoskeleton organization and biogenesis; chemotaxis; protein amino acid phosphorylation; regulation of epidermal growth factor receptor signaling pathway; regulation of cell proliferation; activation of NF-kappaB transcription factor; cell proliferation; cellular response to insulin stimulus; positive regulation of actin filament polymerization; positive regulation of cell proliferation; actin cytoskeleton reorganization; innate immune response; mitotic cell cycle; cell adhesion; cell differentiation; positive regulation of cell migration