CDK6 Antibody – Rabbit Polyclonal

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.

Protein type: Kinase, protein; Protein kinase, CMGC; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily

Cellular Component: nucleoplasm; ruffle; centrosome; cell projection; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; gliogenesis; T cell differentiation in the thymus; cell cycle; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of cell cycle; regulation of erythrocyte differentiation; positive regulation of fibroblast proliferation; regulation of gene expression; cell division; cell dedifferentiation; hemopoietic progenitor cell differentiation; hemopoiesis; negative regulation of osteoblast differentiation; positive regulation of cell-matrix adhesion; cell differentiation; phosphorylation; negative regulation of epithelial cell proliferation