CDK4 Antibody – Rabbit Polyclonal

CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991.

Protein type: Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily

Cellular Component: transcription factor complex; nuclear membrane; tight junction; membrane; perinuclear region of cytoplasm; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleolus; chromatin; nucleus; cytosol

Molecular Function: transferase activity; protein serine/threonine kinase activity; cyclin binding; protein binding; cyclin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein complex binding; kinase activity; ATP binding; protein kinase activity

Biological Process: response to drug; positive regulation of cell size; positive regulation of translation; regulation of cell cycle; positive regulation of apoptosis; response to testosterone stimulus; signal transduction; cell cycle; protein amino acid phosphorylation; regulation of cell proliferation; response to organic substance; positive regulation of fibroblast proliferation; regulation of gene expression; cell division; positive regulation of cell proliferation; response to lead ion; phosphorylation; G1/S transition of mitotic cell cycle