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GLI2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176275

Description: Rabbit IgG polyclonal antibody for Zinc finger protein GLI2(GLI2) detection. Tested with WB in Human.Background: GLI2(Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gli2, Polyclonal Antibody
Full Product Name
Anti-Gli2 antibody
Product Gene Name
anti-GLI2 antibody
Product Synonym Names
Zinc finger protein GLI2; GLI family zinc finger 2; Gli 2 antibody; GLI family zinc finger 2 antibody; GLI kruppel family member 2 antibody; GLI Kruppel family member GLI2 antibody; GLI2 antibody; GLI2_HUMAN antibody; Oncogene GLI2 antibody; Tax helper protein antibody; Tax helper protein 2 antibody; Tax responsive element 2 holding protein antibody; Tax responsive element 25 bp sequence binding protein antibody; THP 2 antibody; THP antibody; THP2 antibody; Zinc finger protein GLI2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
86,482 Da
OMIM
615849
3D Structure
ModBase 3D Structure for P10070
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Gli2 (1444-1463aa MLYYYGQIHMYEQDGGLENL).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-GLI2 antibody
Western Blot (WB)

Western Blot (WB) of anti-GLI2 antibody

Anti-Gli2 antibody, MBS176275, Western blotting
WB: Human Placenta Tissue Lysate
Rabbit Anti-GLI2 Polyclonal Antibody – Cat# MBS176275

Western Blot (WB) of anti-GLI2 antibody

Anti-Gli2 antibody, MBS176275, Western blotting
Lane 1: MCF-7 Cell Lysate
Lane 2: HELA Cell Lysate
Lane 3: SKOV Cell Lysate
Lane 4: HT1080 Cell Lysate
Lane 5: A549 Cell Lysate
Rabbit Anti-GLI2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS176275

Other Notes

Small volumes of anti-GLI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLI2 purchase

MBS176275 is an antibody targeting GLI2. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLI2. It may not necessarily be applicable to this product.

NCBI GI #
215274258
NCBI GeneID
2736
NCBI Accession #
P10070.4
UniProt Primary Accession #
P10070
UniProt Secondary Accession #
O60252; O60253; O60254; O60255; Q15590; Q15591; Q4JHT4
UniProt Related Accession #
P10070
NCBI Official Full Name
Zinc finger protein GLI2
NCBI Official Synonym Full Names
GLI family zinc finger 2
NCBI Official Symbol
GLI2
NCBI Official Synonym Symbols
HPE9; PHS2; THP1; THP2
UniProt Protein Name
Zinc finger protein GLI2
UniProt Synonym Protein Names
GLI family zinc finger protein 2; Tax helper protein
Protein Family
Zinc finger protein
UniProt Gene Name
GLI2
UniProt Entry Name
GLI2_HUMAN
NCBI Protein Information
zinc finger protein GLI2; oncogene GLI2; tax helper protein 1; tax helper protein 2; GLI-Kruppel family member GLI2; tax-responsive element-2 holding protein; glioma-associated oncogene family zinc finger 2; tax-responsive element-25-bp sequence binding protein

NCBI Summary for GLI2

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
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UniProt Comments for GLI2

Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).
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Research Articles on GLI2

1. The transcription factors GLI1 and GLI2 activate the SOCS1 promoter, which contains five putative GLI binding sites, and GLI2 binding to the promoter was shown by chromatin immunoprecipitation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLI2 antibody

 Reference Product  PubMed Publications
 SHH antibody  >291 publications with GLI2 and SHH
 SUFU antibody  >41 publications with GLI2 and SUFU
 KIF3A antibody  >9 publications with GLI2 and KIF3A
 SPOP antibody  >7 publications with GLI2 and SPOP
 IFT88 antibody  >5 publications with GLI2 and IFT88
 RAB23 antibody  >2 publications with GLI2 and RAB23
 STK36 antibody  >2 publications with GLI2 and STK36
 BTRC antibody  >1 publications with GLI2 and BTRC
 IFT172 antibody  >1 publications with GLI2 and IFT172

Pathways associated with anti-GLI2 antibody

 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram

Diseases associated with anti-GLI2 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >73 publications with GLI2 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >66 publications with GLI2 and Nervous System Diseases
 Carcinoma, Basal Cell Antibodies  >56 publications with GLI2 and Carcinoma, Basal Cell
 Skin Neoplasms Antibodies  >41 publications with GLI2 and Skin Neoplasms
 Abnormalities, Multiple Antibodies  >40 publications with GLI2 and Abnormalities, Multiple
 Brain Diseases Antibodies  >38 publications with GLI2 and Brain Diseases
 Craniofacial Abnormalities Antibodies  >32 publications with GLI2 and Craniofacial Abnormalities
 Death Antibodies  >26 publications with GLI2 and Death
 Nervous System Malformations Antibodies  >24 publications with GLI2 and Nervous System Malformations
 Disease Models, Animal Antibodies  >21 publications with GLI2 and Disease Models, Animal

Organs/Tissues associated with anti-GLI2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >120 publications with GLI2 and Embryonic Tissue
 Bone Antibodies  >86 publications with GLI2 and Bone
 Brain Antibodies  >86 publications with GLI2 and Brain
 Lung Antibodies  >36 publications with GLI2 and Lung
 Prostate Antibodies  >33 publications with GLI2 and Prostate
 Liver Antibodies  >30 publications with GLI2 and Liver
 Connective Tissue Antibodies  >19 publications with GLI2 and Connective Tissue
 Heart Antibodies  >14 publications with GLI2 and Heart
 Bone Marrow Antibodies  >12 publications with GLI2 and Bone Marrow
 Mouth Antibodies  >11 publications with GLI2 and Mouth
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