CCR5 Antibody – Rabbit Polyclonal

CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection

Protein type: Membrane protein, multi-pass; Receptor, cytokine; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; plasma membrane; cytosol; endosome; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; actin binding; glycoprotein binding; protein kinase binding

Biological Process: calcium-mediated signaling; positive regulation of interleukin-6 production; defense response; positive regulation of interleukin-1 beta secretion; negative regulation of axon extension; chemotaxis; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; positive regulation of tumor necrosis factor production; signal transduction; positive regulation of apoptosis by virus; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell-cell signaling; calcium ion transport; positive regulation of fever; positive regulation of cell-cell adhesion; immune response; positive regulation of neuron differentiation; inflammatory response; negative regulation of cell migration; positive regulation of inflammatory response