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Annexin IV (ANXA4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176303

Description: Rabbit IgG polyclonal antibody for Annexin A4(ANXA4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: Annexin IV, also known as placental anticoagulant protein II, or zymogen granule membrane-associated protein, 36-KD(ZAP36), is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Annexin IV (ANXA4), Polyclonal Antibody
Full Product Name
Anti-Annexin IV antibody
Product Gene Name
anti-ANXA4 antibody
Product Synonym Names
Annexin A4; annexin A4; 35 beta calcimedin antibody; 35-beta calcimedin antibody; AIV antibody; Annexin 4 antibody; Annexin A4 antibody; Annexin IV(placental anticoagulant protein II) antibody; Annexin IV antibody; Annexin IV placental anticoagulant protein II antibody; Annexin-4 antibody; AnnexinA4 antibody; AnnexinIV antibody; ANX 4 antibody; ANX A4 antibody; ANX4 antibody; ANXA 4 antibody; ANXA4 antibody; ANXA4 protein antibody; ANXA4_HUMAN antibody; Carbohydrate binding protein P33/P41 antibody; Carbohydrate-binding protein p33/p41 antibody; Chromobindin 4 antibody; Chromobindin-4 antibody; Chromobindin4 antibody; DKFZp686H02120 antibody; Endonexin I antibody; EndonexinI antibody; Lipocortin IV antibody; LipocortinIV antibody; MGC75105 antibody; OTTHUMP00000160052 antibody; OTTHUMP00000202207 antibody; P32.5 antibody; P33/41 antibody; PAP II antibody; PAP-II antibody; PAPII antibody; PIG 28 antibody; PIG28 antibody; Placental anticoagulant protein II antibody; PP4 X antibody; PP4-X antibody; PP4X antibody; Proliferation inducing gene 28 antibody; Proliferation inducing protein 28 antibody; Protein II antibody; Xanx-4 antibody; ZAP 36 antibody; ZAP36 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
27,063 Da
OMIM
106491
3D Structure
ModBase 3D Structure for P09525
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Annexin IV (7-21aa TVKAASGFNAMEDAQ), different from the related mouse and rat sequences by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ANXA4 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-ANXA4 antibody

Anti-Annexin IV antibody, MBS176303, Western blotting
Lane 1: Human Placenta Tissue Lysate
Lane 2: Rat Liver Tissue Lysate
Lane 3: 293T Cell Lysate
Lane 4: HEPA Cell Lysate
Lane 5: NIH3T3 Cell Lysate
Rabbit Anti-ANXA4 Polyclonal Antibody – Cat# MBS176303

Immunohistochemistry (IHC) of anti-ANXA4 antibody

Anti-Annexin IV antibody, MBS176303, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-ANXA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176303

Immunohistochemistry (IHC) of anti-ANXA4 antibody

Anti-Annexin IV antibody, MBS176303, IHC(P)
IHC(P): Rat Pancreas Tissue
Rabbit Anti-ANXA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176303

Other Notes

Small volumes of anti-ANXA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA4 purchase

MBS176303 is an antibody targeting ANXA4. Also known as Anti-Annexin IV antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA4. It may not necessarily be applicable to this product.

NCBI GI #
1703319
NCBI GeneID
307
NCBI Accession #
P09525.4
UniProt Primary Accession #
P09525
UniProt Secondary Accession #
Q96F33; Q9BWK1; B4DDF9
UniProt Related Accession #
P09525
NCBI Official Full Name
Annexin A4
NCBI Official Synonym Full Names
annexin A4
NCBI Official Symbol
ANXA4
NCBI Official Synonym Symbols
ANX4; PIG28; ZAP36; HEL-S-274
UniProt Protein Name
Annexin A4
UniProt Synonym Protein Names
35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PP4-X; Placental anticoagulant protein II; PAP-II; Protein II
Protein Family
Annexin
UniProt Gene Name
ANXA4
UniProt Synonym Gene Names
ANX4; PAP-II
UniProt Entry Name
ANXA4_HUMAN
NCBI Protein Information
annexin A4; P32.5; PP4-X; PAP-II; annexin-4; protein II; endonexin I; lipocortin IV; chromobindin-4; 35-beta calcimedin; proliferation-inducing gene 28; proliferation-inducing protein 28; placental anticoagulant protein II; epididymis secretory protein Li 274; carbohydrate-binding protein p33/p41; annexin IV (placental anticoagulant protein II)

NCBI Summary for ANXA4

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for ANXA4

ANXA4: a calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Calcium-binding

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: nuclear membrane; cell surface; perinuclear region of cytoplasm; cytoplasm; plasma membrane; vesicle membrane; nucleus

Molecular Function: identical protein binding; phospholipase inhibitor activity; NF-kappaB binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; epithelial cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of catalytic activity; signal transduction; negative regulation of apoptosis
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Research Articles on ANXA4

1. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANXA4 antibody

 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram

Diseases associated with anti-ANXA4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with ANXA4 and Carcinoma
 Lung Diseases Antibodies  >1 publications with ANXA4 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with ANXA4 and Lung Neoplasms
 Disease Models, Animal Antibodies  >1 publications with ANXA4 and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with ANXA4 and Hyperplasia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ANXA4 and Drug-Related Side Effects and Adverse Reactions
 Inflammation Antibodies  >1 publications with ANXA4 and Inflammation
 Necrosis Antibodies  >1 publications with ANXA4 and Necrosis
 Prostatic Neoplasms Antibodies  >1 publications with ANXA4 and Prostatic Neoplasms

Organs/Tissues associated with anti-ANXA4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with ANXA4 and Blood
 Kidney Antibodies  >3 publications with ANXA4 and Kidney
 Stomach Antibodies  >2 publications with ANXA4 and Stomach
 Liver Antibodies  >2 publications with ANXA4 and Liver
 Uterus Antibodies  >2 publications with ANXA4 and Uterus
 Lung Antibodies  >2 publications with ANXA4 and Lung
 Intestine Antibodies  >2 publications with ANXA4 and Intestine
 Bladder Antibodies  >1 publications with ANXA4 and Bladder
 Pancreas Antibodies  >1 publications with ANXA4 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with ANXA4 and Embryonic Tissue
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