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Peroxiredoxin 3 (PRDX3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176305

Description: Rabbit IgG polyclonal antibody for Thioredoxin-dependent peroxide reductase, mitochondrial(PRDX3) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: PRDX3(peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3, is localized… More details

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Product Overview

Online Datasheet in PDF
Product Name
Peroxiredoxin 3 (PRDX3), Polyclonal Antibody
Full Product Name
Anti-Peroxiredoxin 3 antibody
Product Gene Name
anti-PRDX3 antibody
Product Synonym Names
Thioredoxin-dependent peroxide reductase, mitochondrial; peroxiredoxin 3; Antioxidant Protein 1 antibody; AOP 1 antibody; AOP-1 antibody; AOP1 antibody; HBC189 antibody; MER 5 antibody; MER5 antibody; MGC104387 antibody; MGC24293 antibody; mitochondrial antibody; Mitochondrial thioredoxin dependent peroxide reductase antibody; peroxiredoxin 3 antibody; PeroxiredoxinIII antibody; Peroxiredoxin-3 antibody; Peroxiredoxin3 antibody; PRDX 3 antibody; PRDX3 antibody; PRDX3_HUMAN antibody; PRO1748 antibody; Protein MER5 homolog antibody; PRX III antibody; PRXIII antibody; Prx-III antibody; PRX3 antibody; SP 22 antibody; SP-22 antibody; SP22 antibody; Thioredoxin dependent peroxide reductase mitochondrial antibody; Thioredoxin dependent peroxide reductase precursor antibody; Thioredoxin-dependent peroxide reductase antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
28,127 Da
3D Structure
ModBase 3D Structure for P20108
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3 (240-257aa TIKPSPTASKEYFEKVHQ), identical to the related rat sequence, and different from the related human sequence by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PRDX3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-PRDX3 antibody

Anti-Peroxiredoxin 3 antibody, MBS176305, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-PRDX3 Polyclonal Antibody – Cat# MBS176305

Immunohistochemistry (IHC) of anti-PRDX3 antibody

Anti-Peroxiredoxin 3 antibody, MBS176305, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-PRDX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176305

Immunohistochemistry (IHC) of anti-PRDX3 antibody

Anti-Peroxiredoxin 3 antibody, MBS176305, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-PRDX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176305

Western Blot (WB) of anti-PRDX3 antibody

Anti-Peroxiredoxin 3 antibody, MBS176305, Western blotting
All lanes: Anti Peroxiredoxin 3 (MBS176305) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Rat Lung Tissue Lysate at 50ug
Lane 3: Rat Kidney Tissue Lysate at 50ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: JURKAT Whole Cell Lysate at 40ug
Lane 6: 293T Whole Cell Lysate at 40ug
Lane 7: MCF-7 Whole Cell Lysate at 40ug
Lane 8: A549 Whole Cell Lysate at 40ug
Lane 9: U20S Whole Cell Lysate at 40ug
Predicted bind size: 28KD
Observed bind size: 28KD
Rabbit Anti-PRDX3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS176305

Other Notes

Small volumes of anti-PRDX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX3 purchase

MBS176305 is an antibody targeting PRDX3. Also known as Anti-Peroxiredoxin 3 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX3. It may not necessarily be applicable to this product.

NCBI GI #
126986
NCBI GeneID
11757
NCBI Accession #
P20108.1
UniProt Primary Accession #
P20108
UniProt Related Accession #
P20108
NCBI Official Full Name
Thioredoxin-dependent peroxide reductase, mitochondrial
NCBI Official Synonym Full Names
peroxiredoxin 3
NCBI Official Symbol
Prdx3
NCBI Official Synonym Symbols
Aop1; Ef2l; Mer5; Prx3; SP22; TDXM; D0Tohi1; AW822249
UniProt Protein Name
Thioredoxin-dependent peroxide reductase, mitochondrial
UniProt Synonym Protein Names
Antioxidant protein 1; AOP-1; PRX III; Perioredoxin-3; Protein MER5
Protein Family
Thioredoxin-dependent peroxide reductase
UniProt Gene Name
Prdx3
UniProt Synonym Gene Names
Aop1; Mer5; AOP-1
UniProt Entry Name
PRDX3_MOUSE
NCBI Protein Information
thioredoxin-dependent peroxide reductase, mitochondrial; AOP-1; Prx III; perioredoxin-3; peroxiredoxin III; antioxidant protein; anti-oxidant protein 1; mitochondrial Trx dependent peroxide reductase; mitochondrial thioredoxin dependent peroxide reductase

UniProt Comments for PRDX3

PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family.

Protein type: EC 1.11.1.15; Oxidoreductase

Cellular Component: mitochondrion; early endosome; cytoplasm; IkappaB kinase complex; cytosol; myelin sheath

Molecular Function: antioxidant activity; protein C-terminus binding; identical protein binding; peroxidase activity; thioredoxin peroxidase activity; peroxiredoxin activity; caspase inhibitor activity; oxidoreductase activity; protein kinase binding; kinase binding

Biological Process: negative regulation of kinase activity; mitochondrion organization and biogenesis; response to lipopolysaccharide; negative regulation of caspase activity; activation of NF-kappaB transcription factor; peptidyl-cysteine oxidation; response to hydrogen peroxide; regulation of mitochondrial membrane potential; hydrogen peroxide catabolic process; positive regulation of cell proliferation; myeloid cell differentiation; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis; maternal placenta development
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Research Articles on PRDX3

1. Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRDX3 antibody

 Reference Product  PubMed Publications
 Txn2 antibody  >8 publications with PRDX3 and Txn2
 Sod2 antibody  >6 publications with PRDX3 and Sod2
 Gpx4 antibody  >5 publications with PRDX3 and Gpx4
 Sod1 antibody  >5 publications with PRDX3 and Sod1
 Srxn1 antibody  >4 publications with PRDX3 and Srxn1
 Gpx1 antibody  >3 publications with PRDX3 and Gpx1
 Txn1 antibody  >3 publications with PRDX3 and Txn1
 Cat antibody  >2 publications with PRDX3 and Cat
 Rps6kc1 antibody  >1 publications with PRDX3 and Rps6kc1
 Abra antibody  >1 publications with PRDX3 and Abra

Pathways associated with anti-PRDX3 antibody

 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram

Diseases associated with anti-PRDX3 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >12 publications with PRDX3 and Necrosis
 Inflammation Antibodies  >9 publications with PRDX3 and Inflammation
 Brain Diseases Antibodies  >9 publications with PRDX3 and Brain Diseases
 Liver Diseases Antibodies  >9 publications with PRDX3 and Liver Diseases
 Disease Models, Animal Antibodies  >7 publications with PRDX3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >7 publications with PRDX3 and Cardiovascular Diseases
 Prostatic Diseases Antibodies  >6 publications with PRDX3 and Prostatic Diseases
 Disease Progression Antibodies  >6 publications with PRDX3 and Disease Progression
 Liver Neoplasms Antibodies  >5 publications with PRDX3 and Liver Neoplasms
 Heart Diseases Antibodies  >4 publications with PRDX3 and Heart Diseases

Organs/Tissues associated with anti-PRDX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >31 publications with PRDX3 and Other
 Brain Antibodies  >16 publications with PRDX3 and Brain
 Liver Antibodies  >14 publications with PRDX3 and Liver
 Lung Antibodies  >9 publications with PRDX3 and Lung
 Heart Antibodies  >9 publications with PRDX3 and Heart
 Muscle Antibodies  >8 publications with PRDX3 and Muscle
 Eye Antibodies  >6 publications with PRDX3 and Eye
 Prostate Antibodies  >6 publications with PRDX3 and Prostate
 Bone Antibodies  >6 publications with PRDX3 and Bone
 Bone Marrow Antibodies  >5 publications with PRDX3 and Bone Marrow
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