P2RX7 Antibody – Rabbit Polyclonal

P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Receptor, misc.

Cellular Component: neuron projection; protein complex; integral to plasma membrane; terminal button; integral to nuclear inner membrane; intercellular junction; cytosol; lipid raft; membrane; cell soma; cytoplasm; plasma membrane; synapse; intracellular; neuromuscular junction; external side of plasma membrane

Molecular Function: protein serine/threonine kinase activator activity; protein binding; copper ion binding; zinc ion binding; channel activity; lipopolysaccharide binding; magnesium ion binding; receptor activity; ATP binding; purinergic nucleotide receptor activity; receptor binding; ATP-gated cation channel activity

Biological Process: positive regulation of catalytic activity; positive regulation of apoptosis; positive regulation of T cell mediated cytotoxicity; activation of MAPK activity; cytolysis; programmed cell death; positive regulation of glutamate secretion; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; sensory perception of pain; response to organic cyclic substance; protein amino acid phosphorylation; positive regulation of interleukin-1 alpha secretion; cell surface receptor linked signal transduction; multicellular organismal protein catabolic process; ceramide biosynthetic process; positive regulation of cytolysis; T cell homeostasis; response to electrical stimulus; positive regulation of gamma-aminobutyric acid secretion; response to drug; mitochondrion organization and biogenesis; collagen metabolic process; positive regulation of interleukin-6 production; positive regulation of cytoskeleton organization and biogenesis; regulation of sodium ion transport; protein oligomerization; phospholipid translocation; phagolysosome formation; membrane depolarization; defense response to Gram-positive bacterium; positive regulation of protein secretion; NAD transport; response to bacterium; response to mechanical stimulus; response to zinc ion; cell volume homeostasis; response to calcium ion; phospholipid transfer to membrane; cell morphogenesis; generation of action potential; response to organic substance; T cell proliferation; organic cation transport; positive regulation of mitochondrial depolarization; positive regulation of MAPKKK cascade; plasma membrane organization and biogenesis; calcium ion transport; pore complex biogenesis; inflammatory response; negative regulation of bone resorption; cation transport; negative regulation of MAPKKK cascade; membrane protein ectodomain proteolysis; bleb formation; positive regulation of bone mineralization; response to ATP; positive regulation of ossification; positive regulation of interleukin-1 beta production; synaptic vesicle exocytosis; homeostasis of number of cells within a tissue; skeletal morphogenesis; release of sequestered calcium ion into cytosol; positive regulation of prostaglandin secretion; cellular response to extracellular stimulus; protein processing; gene expression; positive regulation of protein amino acid phosphorylation; positive regulation of cytokine secretion; membrane budding