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TXNRD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176334

Description: Rabbit IgG polyclonal antibody for Thioredoxin reductase 2, mitochondrial(TXNRD2) detection. Tested with WB, IHC-P in Human, Rat.Background: TXNRD2(Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TXNRD2, Polyclonal Antibody
Full Product Name
Anti-TXNRD2 antibody
Product Gene Name
Product Synonym Names
Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 2; mitochondrial antibody; selenoprotein Z antibody; SELZ antibody; Thioredoxin reductase 2 antibody; Thioredoxin reductase 2 mitochondrial antibody; thioredoxin reductase 3 antibody; thioredoxin reductase beta antibody; Thioredoxin reductase TR3 antibody; TR 3 antibody; TR antibody; TR beta antibody; TR-beta antibody; TR3 antibody; TRXR 2 antibody; TRXR2 antibody; TRXR2_HUMAN antibody; TXNRD 2 antibody; Txnrd2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
30,291 Da
OMIM
606448
3D Structure
ModBase 3D Structure for Q9NNW7
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2 (418-434aa RHGQEHVEVYHAHYKPL), different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TXNRD2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-TXNRD2 antibody

Anti-TXNRD2 antibody, MBS176334, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Ovary Tissue Lysate
Lane 3: Rat Liver Tissue Lysate
Lane 4: SMMC Cell Lysate
Rabbit Anti-TXNRD2 Polyclonal Antibody – Cat# MBS176334

Immunohistochemistry (IHC) of anti-TXNRD2 antibody

Anti-TXNRD2 antibody, MBS176334, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-TXNRD2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176334

Other Notes

Small volumes of anti-TXNRD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXNRD2 purchase

MBS176334 is an antibody targeting TXNRD2. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNRD2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Thioredoxin reductase 2, mitochondrial
NCBI Official Synonym Full Names
thioredoxin reductase 2
NCBI Official Symbol
TXNRD2
NCBI Official Synonym Symbols
TR; TR3; SELZ; TRXR2; TR-BETA
UniProt Protein Name
Thioredoxin reductase 2, mitochondrial
UniProt Synonym Protein Names
Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
UniProt Gene Name
TXNRD2
UniProt Synonym Gene Names
KIAA1652; TRXR2; SelZ
UniProt Entry Name
TRXR2_HUMAN
NCBI Protein Information
thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase 3; thioredoxin reductase TR3; thioredoxin reductase beta

NCBI Summary for TXNRD2

This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
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UniProt Comments for TXNRD2

TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; mercury (II) reductase activity; thioredoxin-disulfide reductase activity; FAD binding; mercury ion binding; NADP binding

Biological Process: response to reactive oxygen species; response to oxygen radical; cell redox homeostasis; detoxification of mercury ion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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