Rabbit Anti-ITGB4 Polyclonal Antibody – Cat# MBS176778

Anti- ITGB4 antibody, MBS176778, Western blotting
All lanes: Anti ITGB4 (MBS176778) at 0.5ug/ml
WB: A431 Whole Cell Lysate at 40ug
Predicted bind size: 200KD
Observed bind size: 200KD

Integrin Beta 4 (ITGB4) Antibody – Rabbit Polyclonal

Name: ITGB4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS176778
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176778

Description: Rabbit IgG polyclonal antibody for Integrin beta-4(ITGB4) detection. Tested with WB in Human.Background: ITGB4(Integrin, beta-4), also known as CD104(Cluster of Differentiation 104), is a human gene. The gene encodes the integrin beta 4 subunits,… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Integrin beta 4 (ITGB4), Polyclonal Antibody

Full Product Name

Anti-Integrin beta 4 antibody

Product Gene Name

anti-ITGB4 antibody

Product Synonym Names

Integrin beta-4; integrin, beta 4; CD 104 antibody; CD104 antibody; CD104 antigen antibody; GP150 antibody; Integrin beta 4 subunit antibody; Integrin beta-4 antibody; ITB4_HUMAN antibody; ITG B4 antibody; ITGB 4 antibody; ITGB4 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

106,779 Da

OMIM

226730

3D Structure

ModBase 3D Structure for P16144

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin beta 4 (422-437aa HVCQLPEDQKGNIHLK).

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-ITGB4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-ITGB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGB4 purchase

MBS176778 is an antibody targeting ITGB4. Also known as Anti-Integrin beta 4 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB4. It may not necessarily be applicable to this product.

NCBI GI #

317373584

NCBI GeneID

3691

NCBI Accession #

P16144.5

UniProt Primary Accession #

P16144

UniProt Secondary Accession #

O14690; O14691; O15339; O15340; O15341; Q0VF97; Q9UIQ4; A0AVL6

UniProt Related Accession #

P16144

NCBI Official Full Name

Integrin beta-4

NCBI Official Synonym Full Names

integrin, beta 4

NCBI Official Symbol

ITGB4

NCBI Official Synonym Symbols

CD104

UniProt Protein Name

Integrin beta-4

UniProt Synonym Protein Names

GP150; CD_antigen: CD104

Protein Family

Integrin

UniProt Gene Name

ITGB4

UniProt Entry Name

ITB4_HUMAN

NCBI Protein Information

integrin beta-4; GP150; CD104 antigen; integrin beta-4 subunit

NCBI Summary for ITGB4

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ITGB4

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cell surface; hemidesmosome; leading edge; basal plasma membrane; plasma membrane; basement membrane; integrin complex; receptor complex

Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity

Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; hemidesmosome assembly; filopodium formation; gut development; cell-matrix adhesion; response to wounding; cell motility involved in cell locomotion; mesodermal cell differentiation; autophagy; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Junctionalis With Pyloric Atresia

Research Articles on ITGB4

1. Necl-4 interacts in cis with integrin alpha6 beta4 through their extracellular regions and Necl-4 inhibited the phorbol ester-induced disassembly of hemidesmosomes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB4 antibody

Reference Product	PubMed Publications
MET antibody	>25 publications with ITGB4 and MET
PLEC antibody	>22 publications with ITGB4 and PLEC
ITGA6 antibody	>19 publications with ITGB4 and ITGA6
ITGA3 antibody	>7 publications with ITGB4 and ITGA3
GRB2 antibody	>7 publications with ITGB4 and GRB2
COL17A1 antibody	>6 publications with ITGB4 and COL17A1
SHC1 antibody	>4 publications with ITGB4 and SHC1
PRKCA antibody	>3 publications with ITGB4 and PRKCA

Pathways associated with anti-ITGB4 antibody

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram

Diseases associated with anti-ITGB4 antibody

Disease Name	Pubmed Publications
Epidermolysis Bullosa Antibodies	>76 publications with ITGB4 and Epidermolysis Bullosa
Adenocarcinoma Antibodies	>59 publications with ITGB4 and Adenocarcinoma
Breast Neoplasms Antibodies	>57 publications with ITGB4 and Breast Neoplasms
Epidermolysis Bullosa, Junctional Antibodies	>50 publications with ITGB4 and Epidermolysis Bullosa, Junctional
Pyloric Atresia Antibodies	>43 publications with ITGB4 and Pyloric Atresia
Carcinoma, Squamous Cell Antibodies	>40 publications with ITGB4 and Carcinoma, Squamous Cell
Inflammation Antibodies	>34 publications with ITGB4 and Inflammation
Lung Diseases Antibodies	>32 publications with ITGB4 and Lung Diseases
Lung Neoplasms Antibodies	>32 publications with ITGB4 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>29 publications with ITGB4 and Neoplasms, Experimental

Organs/Tissues associated with anti-ITGB4 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>149 publications with ITGB4 and Skin
Vascular Antibodies	>100 publications with ITGB4 and Vascular
Eye Antibodies	>65 publications with ITGB4 and Eye
Lung Antibodies	>58 publications with ITGB4 and Lung
Nerve Antibodies	>57 publications with ITGB4 and Nerve
Embryonic Tissue Antibodies	>48 publications with ITGB4 and Embryonic Tissue
Stomach Antibodies	>37 publications with ITGB4 and Stomach
Prostate Antibodies	>30 publications with ITGB4 and Prostate
Liver Antibodies	>28 publications with ITGB4 and Liver
Bone Antibodies	>26 publications with ITGB4 and Bone