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TIA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176792

Description: Rabbit IgG polyclonal antibody for Nucleolysin TIA-1 isoform p40(TIA1) detection. Tested with WB in Human, Mouse.Background: TIA1, also called WDM, encodes an RNA-binding protein involved in splicing regulation and translational repression. The… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TIA1, Polyclonal Antibody
Full Product Name
Anti-TIA1 antibody
Product Gene Name
anti-TIA1 antibody
Product Synonym Names
Nucleolysin TIA-1 isoform p40; TIA1 cytotoxic granule-associated RNA binding protein; Cytotoxic granule associated RNA binding protein 1 antibody; Cytotoxic granule associated RNA binding protein antibody; mTIA-1 antibody; Nucleolysin TIA 1 isoform p40 antibody; Nucleolysin TIA-1 isoform p40 antibody; Nucleolysin TIA1 isoform p40 antibodyp40 TIA 1 antibody; p40-TIA-1(containing p15-TIA-1) antibody; p40-TIA-1 antibody; RNA binding protein TIA 1 antibody; RNA binding protein TIA1 antibody; RNA-binding protein TIA-1 antibody; T-cell-restricted intracellular antigen-1 antibody; TIA 1 antibody; TIA 1 cytotoxic granule associated RNA binding protein antibody; Tia antibody; TIA-1 antibody; TIA1 antibody; TIA1 cytotoxic granule associated RNA binding protein antibody; TIA1 cytotoxic granule associated RNA binding protein like 1 antibody; TIA1 protein antibody; TIA1_HUMAN antibody; TIAL1 antibody; TIAR antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
41,801 Da
OMIM
gene 604454
3D Structure
ModBase 3D Structure for P31483
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TIA1 (98-110aa STQRSQDHFHVFV), identical to the related mouse sequence.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TIA1 antibody
Western Blot (WB)

Western Blot (WB) of anti-TIA1 antibody

Anti-TIA1 antibody, MBS176792, Western blotting
Lane 1: JURKAT Cell Lysate
Lane 2: RAJI Cell Lysate
Lane 3: CEM Cell Lysate
Lane 4: HT1080 Cell Lysate
Lane 5: K562 Cell Lysate
Rabbit Anti-TIA1 Polyclonal Antibody – Cat# MBS176792

Other Notes

Small volumes of anti-TIA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIA1 purchase

MBS176792 is an antibody targeting TIA1. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TIA1. It may not necessarily be applicable to this product.

NCBI GI #
206729905
NCBI GeneID
7072
NCBI Accession #
P31483.3
UniProt Primary Accession #
P31483
UniProt Secondary Accession #
Q53SS9
UniProt Related Accession #
P31483
NCBI Official Full Name
Nucleolysin TIA-1 isoform p40
NCBI Official Synonym Full Names
TIA1 cytotoxic granule-associated RNA binding protein
NCBI Official Symbol
TIA1
NCBI Official Synonym Symbols
WDM; TIA-1
UniProt Protein Name
Nucleolysin TIA-1 isoform p40
UniProt Synonym Protein Names
RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; p40-TIA-1
Protein Family
Nucleolysin
UniProt Gene Name
TIA1
UniProt Synonym Gene Names
TIA-1
UniProt Entry Name
TIA1_HUMAN
NCBI Protein Information
nucleolysin TIA-1 isoform p40; p40-TIA-1 (containing p15-TIA-1); T-cell-restricted intracellular antigen-1

NCBI Summary for TIA1

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]
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UniProt Comments for TIA1

TIA1: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: nucleoplasm; stress granule; cytoplasm

Molecular Function: protein binding; nucleotide binding; AU-rich element binding; poly(A) binding

Biological Process: regulation of nuclear mRNA splicing, via spliceosome; apoptosis; negative regulation of translation; negative regulation of cytokine biosynthetic process

Disease: Welander Distal Myopathy
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Research Articles on TIA1

1. TIA1-knockdown HeLa cells show an increase in ribosomes and translational machinery components.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TIA1 antibody

 Reference Product  PubMed Publications
 GZMB antibody  >64 publications with TIA1 and GZMB
 PTGS2 antibody  >5 publications with TIA1 and PTGS2
 G3BP1 antibody  >3 publications with TIA1 and G3BP1
 DCP1A antibody  >3 publications with TIA1 and DCP1A
 IL10 antibody  >3 publications with TIA1 and IL10
 FASTK antibody  >3 publications with TIA1 and FASTK
 COL2A1 antibody  >2 publications with TIA1 and COL2A1

Diseases associated with anti-TIA1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >33 publications with TIA1 and Necrosis
 Skin Neoplasms Antibodies  >28 publications with TIA1 and Skin Neoplasms
 Inflammation Antibodies  >22 publications with TIA1 and Inflammation
 Nervous System Diseases Antibodies  >21 publications with TIA1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >20 publications with TIA1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >17 publications with TIA1 and Liver Diseases
 Liver Neoplasms Antibodies  >11 publications with TIA1 and Liver Neoplasms
 Anemia Antibodies  >7 publications with TIA1 and Anemia
 Fibrosis Antibodies  >7 publications with TIA1 and Fibrosis
 Lung Diseases Antibodies  >6 publications with TIA1 and Lung Diseases

Organs/Tissues associated with anti-TIA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >182 publications with TIA1 and Blood
 Skin Antibodies  >54 publications with TIA1 and Skin
 Bone Antibodies  >35 publications with TIA1 and Bone
 Bone Marrow Antibodies  >33 publications with TIA1 and Bone Marrow
 Liver Antibodies  >26 publications with TIA1 and Liver
 Lymph Node Antibodies  >25 publications with TIA1 and Lymph Node
 Spleen Antibodies  >18 publications with TIA1 and Spleen
 Kidney Antibodies  >15 publications with TIA1 and Kidney
 Lung Antibodies  >14 publications with TIA1 and Lung
 Intestine Antibodies  >14 publications with TIA1 and Intestine
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