• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Caspase-6(p18) (CASP6) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176796

Description: Rabbit IgG polyclonal antibody for Caspase-6(CASP6) detection. Tested with WB, IHC-P, IHC-F in Mouse, Rat.Background: Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Caspase-6(P18) (CASP6), Polyclonal Antibody
Full Product Name
Anti-Caspase-6(P18) antibody
Product Gene Name
anti-CASP6 antibody
Product Synonym Names
Caspase-6; caspase 6, apoptosis-related cysteine peptidase; Apoptosis Related Cysteine Protease antibody; Apoptotic cysteine protease MCH2 antibody; Apoptotic protease MCH 2 antibody; Apoptotic protease Mch-2 antibody; Apoptotic protease MCH2 antibody; Casp 6 antibody; CASP-6 antibody; Casp6 antibody; Caspase 6 antibody; Caspase 6 apoptosis related cysteine protease antibody; Caspase 6 precursor antibody; Caspase 6, apoptosis related cysteine peptidase antibody; Caspase-6 subunit p18 antibody; Caspase6 antibody; Human cysteine protease Mch2 isoform alpha antibody; Mch 2 antibody; Mch2 antibody; OTTHUMP00000162742 antibody; OTTHUMP00000162743 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
31,556 Da
3D Structure
ModBase 3D Structure for O35397
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6 (P18) (7-27aa FYRSREVLDPAEQYKMDHKRR), different from the related mouse sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CASP6 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

Western Blot (WB) of anti-CASP6 antibody

Anti-Caspase-6(P18) antibody, MBS176796, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Kidney Tissue Lysate
Lane 3: Rat Testis Tissue Lysate
Lane 4: NRK Cell Lysate
Lane 5: Mouse Liver Tissue Lysate
Lane 6: Mouse Kidney Tissue Lysate
Lane 7: Mouse Testis Tissue Lysate
Rabbit Anti-CASP6 Polyclonal Antibody – Cat# MBS176796

Immunohistochemistry (IHC) of anti-CASP6 antibody

Anti-Caspase-6(P18) antibody, MBS176796, IHC(P)
IHC(P): Rat Spleen Tissue
Rabbit Anti-CASP6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176796

Immunohistochemistry (IHC) of anti-CASP6 antibody

Anti-Caspase-6(P18) antibody, MBS176796, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-CASP6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176796

Immunohistochemistry (IHC) of anti-CASP6 antibody

Anti-Caspase-6(P18) antibody, MBS176796, IHC(P)
IHC(P): Mouse Lung Tissue
Rabbit Anti-CASP6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176796

Immunohistochemistry (IHC) of anti-CASP6 antibody

Anti-Caspase-6(P18) antibody, MBS176796, IHC(F)
IHC(F): Rat Spleen Tissue
Rabbit Anti-CASP6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176796

Other Notes

Small volumes of anti-CASP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP6 purchase

MBS176796 is an antibody targeting CASP6. Also known as Anti-Caspase-6(P18) antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP6. It may not necessarily be applicable to this product.

NCBI GI #
81886617
NCBI GeneID
83584
NCBI Accession #
O35397.2
UniProt Primary Accession #
O35397
UniProt Related Accession #
O35397
NCBI Official Full Name
Caspase-6
NCBI Official Synonym Full Names
caspase 6
NCBI Official Symbol
Casp6
NCBI Official Synonym Symbols
Mch2
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2Cleaved into the following 2 chains:Caspase-6 subunit p18; Caspase-6 subunit p11
Protein Family
Caspase
UniProt Gene Name
Casp6
UniProt Synonym Gene Names
Mch2; CASP-6
UniProt Entry Name
CASP6_RAT
NCBI Protein Information
caspase-6; CASP-6; apoptotic protease Mch-2

NCBI Summary for CASP6

member of the cysteine-aspartic acid protease (caspase) family that plays a terminal role in apoptosis [RGD, Feb 2006]

UniProt Comments for CASP6

CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.59; Protease

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; cysteine-type endopeptidase activity; endopeptidase activity

Biological Process: lens development in camera-type eye; response to metal ion; positive regulation of retinal cell programmed cell death; apoptosis; positive regulation of apoptosis; acute inflammatory response to non-antigenic stimulus; response to testosterone stimulus; proteolysis; response to organic nitrogen; response to estradiol stimulus; response to organic substance; response to hydrogen peroxide; epithelial cell differentiation; response to heat; response to cytokine stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; response to gamma radiation; response to iron ion
Show more

Research Articles on CASP6

1. Caspase-6 shows a time-dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CASP6 antibody

 Reference Product  PubMed Publications
 Casp3 antibody  >425 publications with CASP6 and Casp3
 Casp8 antibody  >187 publications with CASP6 and Casp8
 Xiap antibody  >17 publications with CASP6 and Xiap
 Apaf1 antibody  >12 publications with CASP6 and Apaf1
 Satb1 antibody  >6 publications with CASP6 and Satb1
 Birc3 antibody  >4 publications with CASP6 and Birc3
 Birc2 antibody  >4 publications with CASP6 and Birc2
 Lmna antibody  >3 publications with CASP6 and Lmna

Pathways associated with anti-CASP6 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Cardiovascular Signaling Pathway antibodies  Cardiovascular Signaling Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram

Organs/Tissues associated with anti-CASP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >80 publications with CASP6 and Brain
 Lung Antibodies  >33 publications with CASP6 and Lung
 Liver Antibodies  >32 publications with CASP6 and Liver
 Kidney Antibodies  >25 publications with CASP6 and Kidney
 Heart Antibodies  >18 publications with CASP6 and Heart
 Prostate Antibodies  >17 publications with CASP6 and Prostate
 Embryonic Tissue Antibodies  >17 publications with CASP6 and Embryonic Tissue
 Thymus Antibodies  >8 publications with CASP6 and Thymus
 Dorsal Root Ganglion Antibodies  >6 publications with CASP6 and Dorsal Root Ganglion
 Ovary Antibodies  >5 publications with CASP6 and Ovary
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000