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FSH Beta (FSHB) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176812

Description: Rabbit IgG polyclonal antibody for Follitropin subunit beta(FSHB) detection. Tested with WB, IHC-P in Human, Mouse.Background: FSHB, also known as Follitropin subunit beta, is a protein that in humans is encoded by the FSHB gene, and this gene is… More details

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Product Overview

Online Datasheet in PDF
Product Name
FSH beta (FSHB), Polyclonal Antibody
Full Product Name
Anti-FSH beta Antibody
Product Gene Name
anti-FSHB antibody
Product Synonym Names
Follitropin subunit beta; follicle stimulating hormone, beta polypeptide; Follicle Stimulating Hormone antibody; Follicle Stimulating Hormone antibody; Follicle stimulating hormone beta polypeptide antibody; Follicle stimulating hormone beta polypeptide antibody; Follicle stimulating hormone beta subunit antibody; Follitropin beta chain antibody; Follitropin beta chain precursor antibody; Follitropin subunit beta antibody; FSH B antibody; FSH-B antibody; FSH-beta antibody; FSHB antibody; FSHbeta antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
14,700 Da
OMIM
gene 229070
3D Structure
ModBase 3D Structure for P01225
Immunogen
E Coli-derived human FSH beta recombinant protein (Position: N19-E129). Human FSH beta shares 90% and 89% amino acid (aa) sequences identity with mouse and rat FSH beta, respectively.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-FSHB antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Testing Data of anti-FSHB antibody

Anti-FSH beta Picoband antibody, MBS176812-1.jpg
All lanes: Anti FSH beta(MBS176812) at 0.5ug/ml
WB: Recombinant Human FSH beta Protein 0.5ng
Predicted bind size: 36KD
Observed bind size: 36KD
Rabbit Anti-FSHB Polyclonal Antibody – Cat# MBS176812

Immunohistochemistry (IHC) of anti-FSHB antibody

Anti-FSH beta Picoband antibody, MBS176812-1.jpg
IHC(P): Mouse Brain Tissue
Rabbit Anti-FSHB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176812

Immunohistochemistry (IHC) of anti-FSHB antibody

Anti-FSH beta Picoband antibody, MBS176812-1.jpg
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-FSHB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176812

Other Notes

Small volumes of anti-FSHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FSHB purchase

MBS176812 is an antibody targeting FSHB. Also known as Anti-FSH beta Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FSHB. It may not necessarily be applicable to this product.

NCBI GI #
120552
NCBI GeneID
2488
NCBI Accession #
P01225.2
UniProt Primary Accession #
P01225
UniProt Secondary Accession #
Q14D61; A2TF08; A5JVV3
UniProt Related Accession #
P01225
NCBI Official Full Name
Follitropin subunit beta
NCBI Official Synonym Full Names
follicle stimulating hormone, beta polypeptide
NCBI Official Symbol
FSHB
UniProt Protein Name
Follitropin subunit beta
UniProt Synonym Protein Names
Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
Protein Family
Follitropin
UniProt Gene Name
FSHB
UniProt Synonym Gene Names
FSH-B; FSH-beta
UniProt Entry Name
FSHB_HUMAN
NCBI Protein Information
follitropin subunit beta; FSH-B; FSH-beta; follitropin beta chain; follitropin, beta chain; follicle-stimulating hormone beta subunit

NCBI Summary for FSHB

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for FSHB

FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function: follicle-stimulating hormone activity; protein binding; hormone activity

Biological Process: progesterone biosynthetic process; follicle-stimulating hormone signaling pathway; peptide hormone processing; female gamete generation; Sertoli cell proliferation; female pregnancy; signal transduction; cellular protein metabolic process; regulation of osteoclast differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration

Disease: Follicle-stimulating Hormone Deficiency, Isolated
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Research Articles on FSHB

1. The combined effect of FSHB GG+FSHR AA may potentiate the FSH pathway, which increases serum levels of FSH and reduces antimullerian hormone in health girls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FSHB antibody

 Reference Product  PubMed Publications
 CGA antibody  >27 publications with FSHB and CGA
 FSHR antibody  >26 publications with FSHB and FSHR
 GNRHR antibody  >15 publications with FSHB and GNRHR
 GNRH1 antibody  >7 publications with FSHB and GNRH1
 BMP2 antibody  >5 publications with FSHB and BMP2
 INHA antibody  >3 publications with FSHB and INHA
 INHBB antibody  >2 publications with FSHB and INHBB
 INHBA antibody  >1 publications with FSHB and INHBA

Pathways associated with anti-FSHB antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram

Diseases associated with anti-FSHB antibody

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >16 publications with FSHB and Infertility, Male
 Kidney Diseases Antibodies  >10 publications with FSHB and Kidney Diseases
 Infertility, Female Antibodies  >10 publications with FSHB and Infertility, Female
 Hypogonadism Antibodies  >5 publications with FSHB and Hypogonadism
 Nervous System Diseases Antibodies  >4 publications with FSHB and Nervous System Diseases
 Weight Gain Antibodies  >1 publications with FSHB and Weight Gain
 Breast Neoplasms Antibodies  >1 publications with FSHB and Breast Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with FSHB and Prenatal Exposure Delayed Effects
 Follicle-stimulating hormone deficiency, isolated Antibodies  >1 publications with FSHB and Follicle-stimulating hormone deficiency, isolated
 Amenorrhea Antibodies  >1 publications with FSHB and Amenorrhea

Organs/Tissues associated with anti-FSHB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with FSHB and Brain
 Pituitary Gland Antibodies  >70 publications with FSHB and Pituitary Gland
 Testis Antibodies  >23 publications with FSHB and Testis
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