Rabbit Anti-KCNN4 Polyclonal Antibody – Cat# MBS176832

Anti-KCNN antibody, MBS176832, Western blotting
All lanes: Anti KCNN(MBS176832) at 0.5ug/ml
WB: HUT Whole Cell Lysate at 40ug
Predicted bind size: 60KD
Observed bind size: 60KD

KCNN4 Antibody – Rabbit Polyclonal

Name: KCNN4 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS176832
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176832

Description: Rabbit IgG polyclonal antibody for Intermediate conductance calcium-activated potassium channel protein 4(KCNN4) detection. Tested with WB in Human, Mouse, Rat.Background: Intermediate conductance calcium-activated potassium channel protein… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KCNN4, Polyclonal Antibody

Full Product Name

Anti-KCNN4 antibody

Product Gene Name

anti-KCNN4 antibody

Product Synonym Names

Intermediate conductance calcium-activated potassium channel protein 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; hIKCa1 antibody; hKCa4 antibody; hSK4 antibody; IK1 antibody; IKCa1 antibody; Intermediate conductance calcium activated potassium channel protein 4 antibody; Intermediate conductance calcium-activated potassium channel protein 4 antibody; KCa3.1 antibody; KCa4 antibody; KCNN 4 antibody; Kcnn4 antibody; KCNN4_HUMAN antibody; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody; Putative Gardos channel antibody; SK4 antibody; SKCa 4 antibody; SKCa4 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

47,696 Da

OMIM

602754

3D Structure

ModBase 3D Structure for O15554

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4 (14-29aa RRKRLLEQEKSLAGWA), different from the related mouse and rat sequences by two amino acids.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-KCNN4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-KCNN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNN4 purchase

MBS176832 is an antibody targeting KCNN4. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNN4. It may not necessarily be applicable to this product.

NCBI GI #

17366160

NCBI GeneID

3783

NCBI Accession #

O15554.1

UniProt Primary Accession #

O15554

UniProt Secondary Accession #

Q53XR4

UniProt Related Accession #

O15554

NCBI Official Full Name

Intermediate conductance calcium-activated potassium channel protein 4

NCBI Official Synonym Full Names

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

NCBI Official Symbol

KCNN4

NCBI Official Synonym Symbols

IK1; SK4; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1

UniProt Protein Name

Intermediate conductance calcium-activated potassium channel protein 4

UniProt Synonym Protein Names

IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel

Protein Family

Intermediate conductance calcium-activated potassium channel protein

UniProt Gene Name

KCNN4

UniProt Synonym Gene Names

IK1; IKCA1; KCA4; SK4; SK4; SKCa 4; SKCa4; IK1

UniProt Entry Name

KCNN4_HUMAN

NCBI Protein Information

intermediate conductance calcium-activated potassium channel protein 4; SKCa4; SKCa 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel

NCBI Summary for KCNN4

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

UniProt Comments for KCNN4

KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: voltage-gated potassium channel complex; cell soma; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: calmodulin binding; protein binding; calcium-activated potassium channel activity; Intermediate conductance calcium-activated potassium channel activity; small conductance calcium-activated potassium channel activity; protein phosphatase binding

Biological Process: phospholipid translocation; synaptic transmission; positive regulation of T cell receptor signaling pathway; positive regulation of protein secretion; immune system process; calcium ion transport; defense response; cell volume homeostasis; saliva secretion; stabilization of membrane potential; potassium ion transport

Research Articles on KCNN4

1. blockade of KCa3.1 attenuates diabetic renal interstitial fibrogenesis through inhibiting activation of fibroblasts

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNN4 antibody

Reference Product	PubMed Publications
PHPT1 antibody	>2 publications with KCNN4 and PHPT1
NTF3 antibody	>1 publications with KCNN4 and NTF3
DERL1 antibody	>1 publications with KCNN4 and DERL1
EGF antibody	>1 publications with KCNN4 and EGF

Pathways associated with anti-KCNN4 antibody

Products by Pathway	Pathway Diagram
Ca2+ Activated K+ Channels Pathway antibodies	Ca2+ Activated K+ Channels Pathway Diagram
Insulin Secretion Pathway antibodies	Insulin Secretion Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Salivary Secretion Pathway antibodies	Salivary Secretion Pathway Diagram
Salivary Secretion Pathway antibodies	Salivary Secretion Pathway Diagram

Diseases associated with anti-KCNN4 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>30 publications with KCNN4 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>25 publications with KCNN4 and Cardiovascular Diseases
Inflammation Antibodies	>25 publications with KCNN4 and Inflammation
Hypertension Antibodies	>10 publications with KCNN4 and Hypertension
Adenocarcinoma Antibodies	>7 publications with KCNN4 and Adenocarcinoma
Carcinoma Antibodies	>7 publications with KCNN4 and Carcinoma
Stroke Antibodies	>7 publications with KCNN4 and Stroke
Kidney Diseases Antibodies	>7 publications with KCNN4 and Kidney Diseases
Hyperplasia Antibodies	>7 publications with KCNN4 and Hyperplasia
Liver Neoplasms Antibodies	>6 publications with KCNN4 and Liver Neoplasms

Organs/Tissues associated with anti-KCNN4 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>115 publications with KCNN4 and Blood
Brain Antibodies	>31 publications with KCNN4 and Brain
Intestine Antibodies	>28 publications with KCNN4 and Intestine
Lung Antibodies	>26 publications with KCNN4 and Lung
Liver Antibodies	>17 publications with KCNN4 and Liver
Bone Antibodies	>13 publications with KCNN4 and Bone
Bone Marrow Antibodies	>11 publications with KCNN4 and Bone Marrow
Pancreas Antibodies	>9 publications with KCNN4 and Pancreas
Embryonic Tissue Antibodies	>6 publications with KCNN4 and Embryonic Tissue
Ovary Antibodies	>5 publications with KCNN4 and Ovary