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KCNIP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176852

Description: Rabbit IgG polyclonal antibody for Calsenilin(KCNIP3) detection. Tested with WB in Human.Background: KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CSEN (KCNIP3), Polyclonal Antibody
Full Product Name
Anti-CSEN antibody
Product Gene Name
anti-KCNIP3 antibody
Product Synonym Names
Calsenilin; Kv channel interacting protein 3, calsenilin; 4933407H12Rik antibody; A type potassium channel modulatory protein 3 antibody; A-type potassium channel modulatory protein 3 antibody; AI413860 antibody; Calsenilin antibody; CSEN antibody; ; DRE Antagonist Modulator antibody; DRE-antagonist modulator antibody; DREAM antibody; EF Hand Transcription Factor antibody; KCHIP 3 antibody; KCHIP3 antibody; KCNIP 3 antibody; KCNIP3 antibody; Kv channel interacting protein 3 antibody; Kv channel-interacting protein 3 antibody; MGC18289 antibody; Potassium channel interacting protein 3 antibody; Presenilin Binding Protein antibody; R74849 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
26,335 Da
OMIM
604662
3D Structure
ModBase 3D Structure for Q9Y2W7
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN (1-16aa MQPAKEVTKASDGSLL).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-KCNIP3 antibody
Western Blot (WB)

Western Blot (WB) of anti-KCNIP3 antibody

Anti- CSEN antibody, MBS176852, Western blotting
All lanes: Anti CSEN (MBS176852) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: U87 Whole Cell Lysate at 40ug
Lane 3: SHG Whole Cell Lysate at 40ug
Predicted bind size: 29KD
Observed bind size: 29KD
Rabbit Anti-KCNIP3 Polyclonal Antibody – Cat# MBS176852

Other Notes

Small volumes of anti-KCNIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNIP3 purchase

MBS176852 is an antibody targeting KCNIP3. Also known as Anti-CSEN antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNIP3. It may not necessarily be applicable to this product.

NCBI GI #
13431428
NCBI GeneID
30818
NCBI Accession #
Q9Y2W7.1
UniProt Primary Accession #
Q9Y2W7
UniProt Secondary Accession #
Q3YAC3; Q3YAC4; Q53TJ5; Q96T40; Q9UJ84; Q9UJ85; H7BY46
UniProt Related Accession #
Q9Y2W7
NCBI Official Full Name
Calsenilin
NCBI Official Synonym Full Names
Kv channel interacting protein 3, calsenilin
NCBI Official Symbol
KCNIP3
NCBI Official Synonym Symbols
CSEN; DREAM; KCHIP3
UniProt Protein Name
Calsenilin
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3
Protein Family
Calsenilin
UniProt Gene Name
KCNIP3
UniProt Synonym Gene Names
CSEN; DREAM; KCHIP3; DREAM; KChIP3
UniProt Entry Name
CSEN_HUMAN
NCBI Protein Information
calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor

NCBI Summary for KCNIP3

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNIP3

calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.

Protein type: Transcription factor; Calcium-binding

Chromosomal Location of Human Ortholog: 2q21.1

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; nucleus; cytosol

Molecular Function: protein C-terminus binding; potassium channel regulator activity; potassium channel activity; DNA binding; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; calcium-dependent protein binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; signal transduction
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Research Articles on KCNIP3

1. Imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNIP3 antibody

 Reference Product  PubMed Publications
 PSEN2 antibody  >5 publications with KCNIP3 and PSEN2
 CASP3 antibody  >4 publications with KCNIP3 and CASP3
 PSEN1 antibody  >4 publications with KCNIP3 and PSEN1
 CREM antibody  >2 publications with KCNIP3 and CREM

Pathways associated with anti-KCNIP3 antibody

 Products by Pathway  Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 TSH Signaling Pathway antibodies  TSH Signaling Pathway Diagram

Diseases associated with anti-KCNIP3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with KCNIP3 and Nervous System Diseases
 Mental Disorders Antibodies  >5 publications with KCNIP3 and Mental Disorders
 Dementia Antibodies  >5 publications with KCNIP3 and Dementia
 Epilepsy Antibodies  >3 publications with KCNIP3 and Epilepsy
 Hypertension Antibodies  >1 publications with KCNIP3 and Hypertension
 Disease Models, Animal Antibodies  >1 publications with KCNIP3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >1 publications with KCNIP3 and Cardiovascular Diseases
 Seizures Antibodies  >1 publications with KCNIP3 and Seizures

Organs/Tissues associated with anti-KCNIP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with KCNIP3 and Brain
 Thyroid Antibodies  >4 publications with KCNIP3 and Thyroid
 Kidney Antibodies  >2 publications with KCNIP3 and Kidney
 Placenta Antibodies  >1 publications with KCNIP3 and Placenta
 Eye Antibodies  >1 publications with KCNIP3 and Eye
 Thymus Antibodies  >1 publications with KCNIP3 and Thymus
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