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MKI67 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176855

Description: Rabbit IgG polyclonal antibody for Antigen KI-67(MKI67) detection. Tested with WB, IHC-P in Human.Background: Ki-67(Proliferation-related Ki-67 antigen), also known as MKI67 or KIA, is a protein that in humans is encoded by the MKI67 gene. From… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ki67 (MKI67), Polyclonal Antibody
Full Product Name
Anti-Ki67 antibody
Product Gene Name
anti-MKI67 antibody
Product Synonym Names
Antigen KI-67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki 67 antibody; Antigen KI-67 antibody; Antigen KI67 antibody; KI67_HUMAN antibody; KIA antibody; MKI67 antibody; Proliferation related Ki 67 antigen antibody; RP11-380J17.2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
319,444 Da
OMIM
176741
3D Structure
ModBase 3D Structure for P46013
Immunogen
E Coli-derived human Ki67 recombinant protein (Position: K2860-I3256).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-MKI67 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-MKI67 antibody

Anti-Ki67 Picoband antibody, MBS176855-1.JPG
IHC(P): Human Tonsil Tissue
Rabbit Anti-MKI67 Polyclonal Antibody – Cat# MBS176855

Testing Data of anti-MKI67 antibody

Anti-Ki67 Picoband antibody, MBS176855-2.jpg
All lanes: Anti-Ki67(MBS176855) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: MCF-7 Whole Cell Lysate at 40ug
Lane 3: COLO320 Whole Cell Lysate at 40ug
Lane 4: HEPG2 Whole Cell Lysate at 40ug
Lane 5: SKOV Whole Cell Lysate at 40ug
Predicted bind size: 358KD
Observed bind size: 358KD
Rabbit Anti-MKI67 Polyclonal Antibody, Testing Data – Cat# MBS176855

Other Notes

Small volumes of anti-MKI67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MKI67 purchase

MBS176855 is an antibody targeting MKI67. Also known as Anti-Ki67 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MKI67. It may not necessarily be applicable to this product.

NCBI GI #
118572663
NCBI GeneID
4288
NCBI Accession #
P46013.2
UniProt Primary Accession #
P46013
UniProt Secondary Accession #
Q5VWH2
UniProt Related Accession #
P46013
NCBI Official Full Name
Antigen KI-67
NCBI Official Synonym Full Names
marker of proliferation Ki-67
NCBI Official Symbol
MKI67
NCBI Official Synonym Symbols
KIA; MIB-; MIB-1; PPP1R105
UniProt Protein Name
Antigen KI-67
Protein Family
Proliferation marker protein
UniProt Gene Name
MKI67
UniProt Entry Name
KI67_HUMAN
NCBI Protein Information
antigen KI-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; antigen identified by monoclonal antibody Ki-67

NCBI Summary for MKI67

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

UniProt Comments for MKI67

KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; ATP binding

Biological Process: cell proliferation; meiosis
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Research Articles on MKI67

1. high Ki-67 labeling index is predictive sign of a poor prognosis in women with resistant prolactinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MKI67 antibody

 Reference Product  PubMed Publications
 BIRC5 antibody  >108 publications with MKI67 and BIRC5
 TOP2A antibody  >26 publications with MKI67 and TOP2A
 CDK1 antibody  >15 publications with MKI67 and CDK1
 CCNA2 antibody  >9 publications with MKI67 and CCNA2
 MKI67IP antibody  >9 publications with MKI67 and MKI67IP
 PRC1 antibody  >2 publications with MKI67 and PRC1
 KIF15 antibody  >1 publications with MKI67 and KIF15
 NCAPG antibody  >1 publications with MKI67 and NCAPG

Diseases associated with anti-MKI67 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2315 publications with MKI67 and Adenocarcinoma
 Breast Neoplasms Antibodies  >1786 publications with MKI67 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1526 publications with MKI67 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >1061 publications with MKI67 and Carcinoma, Squamous Cell
 Adenoma Antibodies  >731 publications with MKI67 and Adenoma
 Hyperplasia Antibodies  >624 publications with MKI67 and Hyperplasia
 Colorectal Neoplasms Antibodies  >620 publications with MKI67 and Colorectal Neoplasms
 Necrosis Antibodies  >576 publications with MKI67 and Necrosis
 Neoplasms, Experimental Antibodies  >575 publications with MKI67 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >566 publications with MKI67 and Lung Neoplasms
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