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CXCR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176866

Background: Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCR3, Polyclonal Antibody
Full Product Name
Anti-CXCR3 Antibody
Product Gene Name
anti-CXCR3 antibody
Product Synonym Names
CD183 antigen; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; CKR-L2IP-10 receptor; CMKAR3; C-X-C chemokine receptor type 3; CXCR3; CXC-R3; CXCR-3; G protein-coupled receptor 9CD182; GPR9; GPR9Mig-R; Interferon-inducible protein 10 receptor; IP10 receptor; IP10-R; Mig receptor; MigR CXCR3 CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR C-X-C motif chemokine receptor 3 C-X-C chemokine receptor type 3|G protein-coupled receptor 9|IP-10 receptor|Mig receptor|chemokine (C-X-C motif) receptor 3|chemokine receptor 3|interferon-inducible protein 10 receptor
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
300574
3D Structure
ModBase 3D Structure for P49682
Immunogen
E Coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
0.2ml of distilled water will yield a concentration of 500ug/ml.
Recommended Detection Systems
Our lab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC-P.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CXCR3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CXCR3 antibody
WB: 0.1-0.5ug/ml; Human
IHC (Paraffin-embedded Section): 0.5-1ug/ml; Human, Rat; By Heat
WB: The detection limit for CXCR3 is approximately 0.25ng/lane under reducing conditions.
Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunohistochemistry (IHC) of anti-CXCR3 antibody

Anti-CXCR3 Picoband antibody, MBS176866-1.JPG
IHC(P): Rat Kidney Tissue
Rabbit Anti-CXCR3 Polyclonal Antibody – Cat# MBS176866

Immunohistochemistry (IHC) of anti-CXCR3 antibody

Anti-CXCR3 Picoband antibody, MBS176866-2.JPG
IHC(P): Human Tonsil Tissue
Rabbit Anti-CXCR3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176866

Immunohistochemistry (IHC) of anti-CXCR3 antibody

Anti-CXCR3 Picoband antibody, MBS176866-3.JPG
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-CXCR3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176866

Other Notes

Small volumes of anti-CXCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR3 purchase

MBS176866 is an antibody targeting CXCR3. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.

NCBI GI #
2829400
NCBI GeneID
2833
NCBI Accession #
P49682.2
UniProt Primary Accession #
P49682
UniProt Secondary Accession #
O15185; Q7Z710; Q9P2T4; Q9P2T5; B2R982
UniProt Related Accession #
P49682
NCBI Official Full Name
C-X-C chemokine receptor type 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 3
NCBI Official Symbol
CXCR3
NCBI Official Synonym Symbols
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
UniProt Protein Name
C-X-C chemokine receptor type 3
UniProt Synonym Protein Names
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCR3
UniProt Synonym Gene Names
GPR9; CXC-R3; CXCR-3; IP-10 receptor
UniProt Entry Name
CXCR3_HUMAN
NCBI Protein Information
C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor

NCBI Summary for CXCR3

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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UniProt Comments for CXCR3

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: C-X-C chemokine binding; chemokine receptor activity; chemokine binding; receptor activity; C-X-C chemokine receptor activity

Biological Process: apoptosis; positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; negative regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; negative regulation of endothelial cell proliferation; regulation of leukocyte migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of release of sequestered calcium ion into cytosol; angiogenesis; inflammatory response; cell adhesion; cell motility
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Research Articles on CXCR3

1. Post-transplant enhanced CXCL10/CXCR3 signaling in small-for-size liver grafts directly induced endothelial progenitor cell mobilization

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCR3 antibody

 Reference Product  PubMed Publications
 CXCL10 antibody  >803 publications with CXCR3 and CXCL10
 CD4 antibody  >624 publications with CXCR3 and CD4
 CXCL9 antibody  >460 publications with CXCR3 and CXCL9
 CXCL11 antibody  >298 publications with CXCR3 and CXCL11
 CCL5 antibody  >141 publications with CXCR3 and CCL5
 CXCL13 antibody  >27 publications with CXCR3 and CXCL13
 CCL11 antibody  >25 publications with CXCR3 and CCL11
 PF4 antibody  >14 publications with CXCR3 and PF4
 CCL7 antibody  >9 publications with CXCR3 and CCL7
 CCL13 antibody  >3 publications with CXCR3 and CCL13

Pathways associated with anti-CXCR3 antibody

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CXCR3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >565 publications with CXCR3 and Inflammation
 Autoimmune Diseases Antibodies  >308 publications with CXCR3 and Autoimmune Diseases
 Necrosis Antibodies  >202 publications with CXCR3 and Necrosis
 Lung Diseases Antibodies  >181 publications with CXCR3 and Lung Diseases
 Hypersensitivity Antibodies  >138 publications with CXCR3 and Hypersensitivity
 Liver Diseases Antibodies  >118 publications with CXCR3 and Liver Diseases
 Carcinoma Antibodies  >106 publications with CXCR3 and Carcinoma
 Cardiovascular Diseases Antibodies  >94 publications with CXCR3 and Cardiovascular Diseases
 Fibrosis Antibodies  >75 publications with CXCR3 and Fibrosis
 Kidney Diseases Antibodies  >62 publications with CXCR3 and Kidney Diseases

Organs/Tissues associated with anti-CXCR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1448 publications with CXCR3 and Blood
 Brain Antibodies  >137 publications with CXCR3 and Brain
 Spleen Antibodies  >117 publications with CXCR3 and Spleen
 Intestine Antibodies  >68 publications with CXCR3 and Intestine
 Muscle Antibodies  >54 publications with CXCR3 and Muscle
 Connective Tissue Antibodies  >14 publications with CXCR3 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with CXCR3 and Uncharacterized Tissue
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