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LASP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176990

Description: Rabbit IgG polyclonal antibody for LIM and SH3 domain protein 1(LASP1) detection. Tested with WB, IHC-P in Human.Background: LASP1(LIM and SH3 domain protein 1), also known as LASP1, is a protein that in humans is encoded by the LASP1 gene. This… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LASP1, Polyclonal Antibody
Full Product Name
Anti-LASP1 antibody
Product Gene Name
anti-LASP1 antibody
Product Synonym Names
LIM and SH3 domain protein 1; LIM and SH3 protein 1; LASP 1 antibody; LASP-1 antibody; LASP1 antibody; LASP1_HUMAN antibody; LIM and SH3 domain protein 1 antibody; LIM and SH3 protein 1 antibody; Metastatic lymph node gene 50 protein antibody; MLN 50 antibody; MLN50 antibody; OTTHUMP00000164238 antibody; OTTHUMP00000164239 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
23,181 Da
OMIM
602920
3D Structure
ModBase 3D Structure for Q14847
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human LASP1 (152-168aa YRRPLEQQQPHHIPTSA).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-LASP1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-LASP1 antibody

Anti-LASP1 antibody, MBS176990, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: MCF-7 Cell Lysate
Rabbit Anti-LASP1 Polyclonal Antibody – Cat# MBS176990

Immunohistochemistry (IHC) of anti-LASP1 antibody

Anti-LASP1 antibody, MBS176990, IHC(P)
IHC(P): Human Placenta Tissue
Rabbit Anti-LASP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176990

Other Notes

Small volumes of anti-LASP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LASP1 purchase

MBS176990 is an antibody targeting LASP1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LASP1. It may not necessarily be applicable to this product.

NCBI GI #
3122342
NCBI GeneID
3927
NCBI Accession #
Q14847.2
UniProt Primary Accession #
Q14847
UniProt Secondary Accession #
Q96ED2; Q96IG0; B4DGQ0
UniProt Related Accession #
Q14847
NCBI Official Full Name
LIM and SH3 domain protein 1
NCBI Official Synonym Full Names
LIM and SH3 protein 1
NCBI Official Symbol
LASP1
NCBI Official Synonym Symbols
MLN50; Lasp-1
UniProt Protein Name
LIM and SH3 domain protein 1
UniProt Synonym Protein Names
Metastatic lymph node gene 50 protein; MLN 50
Protein Family
LIM and SH3 domain protein
UniProt Gene Name
LASP1
UniProt Synonym Gene Names
MLN50; LASP-1; MLN 50
UniProt Entry Name
LASP1_HUMAN
NCBI Protein Information
LIM and SH3 domain protein 1; metastatic lymph node gene 50 protein

NCBI Summary for LASP1

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
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UniProt Comments for LASP1

Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11-q21.3

Cellular Component: cortical actin cytoskeleton; focal adhesion

Molecular Function: actin filament binding; protein binding; SH3/SH2 adaptor activity; zinc ion binding; ion transmembrane transporter activity

Biological Process: positive regulation of signal transduction; ion transport
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Research Articles on LASP1

1. LASP1 was a direct target of miR-218 in prostate cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LASP1 antibody

 Reference Product  PubMed Publications
 ZYX antibody  >4 publications with LASP1 and ZYX
 MLLT6 antibody  >3 publications with LASP1 and MLLT6

Diseases associated with anti-LASP1 antibody

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >5 publications with LASP1 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with LASP1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with LASP1 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with LASP1 and Disease Models, Animal
 Hyperplasia Antibodies  >2 publications with LASP1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >2 publications with LASP1 and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >2 publications with LASP1 and Prostatic Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with LASP1 and Abnormalities, Drug-Induced
 Prenatal Injuries Antibodies  >1 publications with LASP1 and Prenatal Injuries
 Inflammation Antibodies  >1 publications with LASP1 and Inflammation

Organs/Tissues associated with anti-LASP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with LASP1 and Brain
 Nerve Antibodies  >8 publications with LASP1 and Nerve
 Muscle Antibodies  >8 publications with LASP1 and Muscle
 Liver Antibodies  >7 publications with LASP1 and Liver
 Prostate Antibodies  >7 publications with LASP1 and Prostate
 Lymph Antibodies  >6 publications with LASP1 and Lymph
 Bone Antibodies  >5 publications with LASP1 and Bone
 Lymph Node Antibodies  >5 publications with LASP1 and Lymph Node
 Stomach Antibodies  >3 publications with LASP1 and Stomach
 Bladder Antibodies  >3 publications with LASP1 and Bladder
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