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PTGS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS176993

Description: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1(PTGS1) detection. Tested with WB, IHC-P in Human, Rat.Background: Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or mitochondrial cytochrome c… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COX1 (PTGS1), Polyclonal Antibody
Full Product Name
Anti-COX1 antibody
Product Gene Name
anti-PTGS1 antibody
Product Synonym Names
Prostaglandin G/H synthase 1; prostaglandin-endoperoxide synthase 1; COX 1 antibody; COX 3 antibody; COX-1 antibody; COX1 antibody; COX3 antibody; Cyclooxygenase 1 antibody; Cyclooxygenase 3, included antibody; Cyclooxygenase-1 antibody; Cyclooxygenase1 antibody; EC 1.14.99.1 antibody; Partial COX1 proteins, included antibody; PCOX 1 antibody; PCOX1 antibody; PGG/HS antibody; PGH synthase 1 antibody; PGH1_HUMAN antibody; PGHS 1 antibody; PGHS-1 antibody; PGHS1 antibody; PHS 1 antibody; PHS1 antibody; Prostaglandin endoperoxide synthase 1 antibody; Prostaglandin G/H synthase 1 antibody; Prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin H Synthase 1 antibody; Prostaglandin H2 synthase 1 antibody; Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin-endoperoxide synthase 1 antibody; PTGHS antibody; PTGS 1 antibody; PTGS1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
72,010 Da
OMIM
176805
3D Structure
ModBase 3D Structure for P23219
Immunogen
E Coli-derived human COX1 recombinant protein (Position: E318-L599). Human COX1 shares 90% and 89% amino acid (aa) sequence identity with mouse and ratCOX1, respectively.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PTGS1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC) of anti-PTGS1 antibody

Anti-COX1 Picoband antibody, MBS176993-1.JPG
IHC(P): Human Intestinal Cancer Tissue
Rabbit Anti-PTGS1 Polyclonal Antibody – Cat# MBS176993

Immunohistochemistry (IHC) of anti-PTGS1 antibody

Anti-COX1 Picoband antibody, MBS176993-2.JPG
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-PTGS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176993

Immunohistochemistry (IHC) of anti-PTGS1 antibody

Anti-COX1 Picoband antibody, MBS176993-3.JPG
IHC(P): Rat Intestine Tissue
Rabbit Anti-PTGS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176993

Immunohistochemistry (IHC) of anti-PTGS1 antibody

Anti-COX1 Picoband antibody, MBS176993-4.JPG
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-PTGS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS176993

Testing Data of anti-PTGS1 antibody

Anti-COX1 Picoband antibody, MBS176993-5.jpg
All lanes: Anti-COX1(MBS176993) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 40ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: JURKAT Whole Cell Lysate at 40ug
Lane 4: K562 Whole Cell Lysate at 40ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Lane 6: A549 Whole Cell Lysate at 40ug
Predicted bind size: 69KD
Observed bind size: 69KD
Rabbit Anti-PTGS1 Polyclonal Antibody, Testing Data – Cat# MBS176993

Other Notes

Small volumes of anti-PTGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGS1 purchase

MBS176993 is an antibody targeting PTGS1. Also known as Anti-COX1 antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGS1. It may not necessarily be applicable to this product.

NCBI GI #
317373262
NCBI GeneID
5742
NCBI Accession #
P23219.2
UniProt Primary Accession #
P23219
UniProt Secondary Accession #
Q15122; Q3HY28; Q3HY29; Q5T7T6; Q5T7T7; Q5T7T8; A8K1V7; B4DHQ2; B4E2S5
UniProt Related Accession #
P23219
NCBI Official Full Name
Prostaglandin G/H synthase 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Official Symbol
PTGS1
NCBI Official Synonym Symbols
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
Protein Family
Prostaglandin G/H synthase
UniProt Gene Name
PTGS1
UniProt Synonym Gene Names
COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1
UniProt Entry Name
PGH1_HUMAN
NCBI Protein Information
prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1

NCBI Summary for PTGS1

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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UniProt Comments for PTGS1

COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation
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Research Articles on PTGS1

1. Data indicate that Protectin DX inhibited both cyclooxygenase-1 and -2 (COX-1 and COX-2) in neutrophils.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGS1 antibody

 Reference Product  PubMed Publications
 ALOX5 antibody  >109 publications with PTGS1 and ALOX5
 PLA2G4A antibody  >95 publications with PTGS1 and PLA2G4A
 PTGES antibody  >14 publications with PTGS1 and PTGES
 PTGIS antibody  >8 publications with PTGS1 and PTGIS
 ALOX12 antibody  >7 publications with PTGS1 and ALOX12
 PTGES2 antibody  >5 publications with PTGS1 and PTGES2
 PTGES3 antibody  >4 publications with PTGS1 and PTGES3
 TBXAS1 antibody  >3 publications with PTGS1 and TBXAS1
 PLA2G2A antibody  >2 publications with PTGS1 and PLA2G2A

Pathways associated with anti-PTGS1 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 COX Reactions Pathway antibodies  COX Reactions Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-PTGS1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >981 publications with PTGS1 and Inflammation
 Cardiovascular Diseases Antibodies  >482 publications with PTGS1 and Cardiovascular Diseases
 Pain Antibodies  >343 publications with PTGS1 and Pain
 Necrosis Antibodies  >280 publications with PTGS1 and Necrosis
 Carcinoma Antibodies  >273 publications with PTGS1 and Carcinoma
 Edema Antibodies  >227 publications with PTGS1 and Edema
 Heart Diseases Antibodies  >158 publications with PTGS1 and Heart Diseases
 Hypertension Antibodies  >146 publications with PTGS1 and Hypertension
 Stomach Ulcer Antibodies  >142 publications with PTGS1 and Stomach Ulcer
 Lung Diseases Antibodies  >127 publications with PTGS1 and Lung Diseases

Organs/Tissues associated with anti-PTGS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1257 publications with PTGS1 and Blood
 Vascular Antibodies  >691 publications with PTGS1 and Vascular
 Brain Antibodies  >375 publications with PTGS1 and Brain
 Stomach Antibodies  >355 publications with PTGS1 and Stomach
 Muscle Antibodies  >346 publications with PTGS1 and Muscle
 Kidney Antibodies  >295 publications with PTGS1 and Kidney
 Heart Antibodies  >253 publications with PTGS1 and Heart
 Intestine Antibodies  >219 publications with PTGS1 and Intestine
 Lung Antibodies  >215 publications with PTGS1 and Lung
 Liver Antibodies  >194 publications with PTGS1 and Liver
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